Conjugated linoleic acid (CLA) promotes endurance capacity via peroxisome proliferator-activated receptor δ-mediated mechanism in mice
Previously, it was reported that conjugated linoleic acid (CLA) with exercise training potentially improved endurance capacity via the peroxisome proliferator-activated receptor δ (PPARδ)-mediated mechanism in mice. This study determined the role of exercise and/or CLA in endurance capacity and PPAR...
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| Veröffentlicht in: | The Journal of nutritional biochemistry 2016-12, Vol.38, p.125-133 |
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| description | Previously, it was reported that conjugated linoleic acid (CLA) with exercise training potentially improved endurance capacity via the peroxisome proliferator-activated receptor δ (PPARδ)-mediated mechanism in mice. This study determined the role of exercise and/or CLA in endurance capacity and PPARδ-associated regulators. Male 129Sv/J mice were fed either control (soybean oil) or CLA (0.5%) containing diets for 4 weeks and were further divided into sedentary or training regimes. CLA supplementation significantly reduced body weight and fat mass independent of exercise during the experimental period. Endurance capacity was significantly improved by CLA supplementation, while no effect of exercise was observed. Similarly, CLA treatment significantly increased expressions of sirtuin 1 and PPARγ coactivator-1α, up-stream regulators of PPARδ, in both sedentary and trained animals. With respect to downstream markers of PPARδ, CLA up-regulated the key biomarker needed to stimulate mitochondrial biogenesis, nuclear respiratory factor 1. Moreover, CLA supplementation significantly induced overall genes associated with muscle fibers, such as type I (slow-twitch) and type II (fast twitch). Taken together, it suggests that CLA improves endurance capacity independent of mild-intensity exercise via PPARδ-mediated mechanism. |
| doi_str_mv | 10.1016/j.jnutbio.2016.08.005 |
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This study determined the role of exercise and/or CLA in endurance capacity and PPARδ-associated regulators. Male 129Sv/J mice were fed either control (soybean oil) or CLA (0.5%) containing diets for 4 weeks and were further divided into sedentary or training regimes. CLA supplementation significantly reduced body weight and fat mass independent of exercise during the experimental period. Endurance capacity was significantly improved by CLA supplementation, while no effect of exercise was observed. Similarly, CLA treatment significantly increased expressions of sirtuin 1 and PPARγ coactivator-1α, up-stream regulators of PPARδ, in both sedentary and trained animals. With respect to downstream markers of PPARδ, CLA up-regulated the key biomarker needed to stimulate mitochondrial biogenesis, nuclear respiratory factor 1. Moreover, CLA supplementation significantly induced overall genes associated with muscle fibers, such as type I (slow-twitch) and type II (fast twitch). Taken together, it suggests that CLA improves endurance capacity independent of mild-intensity exercise via PPARδ-mediated mechanism.</description><identifier>ISSN: 0955-2863</identifier><identifier>EISSN: 1873-4847</identifier><identifier>DOI: 10.1016/j.jnutbio.2016.08.005</identifier><identifier>PMID: 27736732</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adiposity ; Animals ; Biomarkers - metabolism ; CLA ; Conjugated linoleic acid ; Dietary Supplements - adverse effects ; Endurance capacity ; Energy Intake ; Energy Metabolism ; Gene Expression Regulation ; Linoleic Acids, Conjugated - administration & dosage ; Linoleic Acids, Conjugated - adverse effects ; Male ; Mice, 129 Strain ; Mitochondria, Muscle - metabolism ; Mitochondrial biogenesis ; Mitochondrial Dynamics ; Muscle metabolism ; Muscle, Skeletal - metabolism ; Nuclear Respiratory Factor 1 - agonists ; Nuclear Respiratory Factor 1 - genetics ; Nuclear Respiratory Factor 1 - metabolism ; Organelle Biogenesis ; Performance-Enhancing Substances - administration & dosage ; Performance-Enhancing Substances - adverse effects ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - agonists ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism ; Physical Endurance ; PPAR gamma - agonists ; PPAR gamma - genetics ; PPAR gamma - metabolism ; Random Allocation ; Sirtuin 1 - chemistry ; Sirtuin 1 - genetics ; Sirtuin 1 - metabolism ; Weight Gain</subject><ispartof>The Journal of nutritional biochemistry, 2016-12, Vol.38, p.125-133</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-3c3df049e0c80a8e3433e435ac808374e7bc51d6f72ec4458a24e16745c9ca363</citedby><cites>FETCH-LOGICAL-c412t-3c3df049e0c80a8e3433e435ac808374e7bc51d6f72ec4458a24e16745c9ca363</cites><orcidid>0000-0001-9727-0899</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jnutbio.2016.08.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27736732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Yoo</creatorcontrib><creatorcontrib>Kim, Daeyoung</creatorcontrib><creatorcontrib>Park, Yeonhwa</creatorcontrib><title>Conjugated linoleic acid (CLA) promotes endurance capacity via peroxisome proliferator-activated receptor δ-mediated mechanism in mice</title><title>The Journal of nutritional biochemistry</title><addtitle>J Nutr Biochem</addtitle><description>Previously, it was reported that conjugated linoleic acid (CLA) with exercise training potentially improved endurance capacity via the peroxisome proliferator-activated receptor δ (PPARδ)-mediated mechanism in mice. This study determined the role of exercise and/or CLA in endurance capacity and PPARδ-associated regulators. Male 129Sv/J mice were fed either control (soybean oil) or CLA (0.5%) containing diets for 4 weeks and were further divided into sedentary or training regimes. CLA supplementation significantly reduced body weight and fat mass independent of exercise during the experimental period. Endurance capacity was significantly improved by CLA supplementation, while no effect of exercise was observed. Similarly, CLA treatment significantly increased expressions of sirtuin 1 and PPARγ coactivator-1α, up-stream regulators of PPARδ, in both sedentary and trained animals. With respect to downstream markers of PPARδ, CLA up-regulated the key biomarker needed to stimulate mitochondrial biogenesis, nuclear respiratory factor 1. Moreover, CLA supplementation significantly induced overall genes associated with muscle fibers, such as type I (slow-twitch) and type II (fast twitch). Taken together, it suggests that CLA improves endurance capacity independent of mild-intensity exercise via PPARδ-mediated mechanism.</description><subject>Adiposity</subject><subject>Animals</subject><subject>Biomarkers - metabolism</subject><subject>CLA</subject><subject>Conjugated linoleic acid</subject><subject>Dietary Supplements - adverse effects</subject><subject>Endurance capacity</subject><subject>Energy Intake</subject><subject>Energy Metabolism</subject><subject>Gene Expression Regulation</subject><subject>Linoleic Acids, Conjugated - administration & dosage</subject><subject>Linoleic Acids, Conjugated - adverse effects</subject><subject>Male</subject><subject>Mice, 129 Strain</subject><subject>Mitochondria, Muscle - metabolism</subject><subject>Mitochondrial biogenesis</subject><subject>Mitochondrial Dynamics</subject><subject>Muscle metabolism</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Nuclear Respiratory Factor 1 - agonists</subject><subject>Nuclear Respiratory Factor 1 - genetics</subject><subject>Nuclear Respiratory Factor 1 - metabolism</subject><subject>Organelle Biogenesis</subject><subject>Performance-Enhancing Substances - administration & dosage</subject><subject>Performance-Enhancing Substances - adverse effects</subject><subject>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - agonists</subject><subject>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics</subject><subject>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism</subject><subject>Physical Endurance</subject><subject>PPAR gamma - agonists</subject><subject>PPAR gamma - genetics</subject><subject>PPAR gamma - metabolism</subject><subject>Random Allocation</subject><subject>Sirtuin 1 - chemistry</subject><subject>Sirtuin 1 - genetics</subject><subject>Sirtuin 1 - metabolism</subject><subject>Weight Gain</subject><issn>0955-2863</issn><issn>1873-4847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuO1DAQhi0EYpqBI4C8HBYJjh-xe4VGLV5SS2xgbbmdClSUxMF2WjMn4EKcgzPhnm7YsipV6avX_xPysmF1w5r2zVAP85oPGGpe0pqZmjH1iGwao0UljdSPyYZtlaq4acUVeZbSwBjjUrVPyRXXWrRa8A35uQvzsH5zGTo64hxGQE-dx47e7Pa3r-kSwxQyJApzt0Y3e6DeLQXI9_SIji4Qwx2mMMEJHbGH6HKIlfMZjw9TI3hYSon-_lVN0OFDcQL_3c2YJoozndDDc_Kkd2OCF5d4Tb6-f_dl97Haf_7waXe7r7xseK6EF13P5BaYN8wZEFIIkEK5khqhJeiDV03X9pqDl1IZxyU0rZbKb70TrbgmN-e55dofK6RsJ0wextHNENZkGyOU5Jq3sqDqjPoYUorQ2yXi5OK9bZg9eWAHe_HAnjywzNjiQel7dVmxHsrD_7r-il6At2cAyqNHhGiTRyjSdljEyrYL-J8VfwCmYp3h</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Kim, Yoo</creator><creator>Kim, Daeyoung</creator><creator>Park, Yeonhwa</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9727-0899</orcidid></search><sort><creationdate>201612</creationdate><title>Conjugated linoleic acid (CLA) promotes endurance capacity via peroxisome proliferator-activated receptor δ-mediated mechanism in mice</title><author>Kim, Yoo ; Kim, Daeyoung ; Park, Yeonhwa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-3c3df049e0c80a8e3433e435ac808374e7bc51d6f72ec4458a24e16745c9ca363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adiposity</topic><topic>Animals</topic><topic>Biomarkers - metabolism</topic><topic>CLA</topic><topic>Conjugated linoleic acid</topic><topic>Dietary Supplements - adverse effects</topic><topic>Endurance capacity</topic><topic>Energy Intake</topic><topic>Energy Metabolism</topic><topic>Gene Expression Regulation</topic><topic>Linoleic Acids, Conjugated - administration & dosage</topic><topic>Linoleic Acids, Conjugated - adverse effects</topic><topic>Male</topic><topic>Mice, 129 Strain</topic><topic>Mitochondria, Muscle - metabolism</topic><topic>Mitochondrial biogenesis</topic><topic>Mitochondrial Dynamics</topic><topic>Muscle metabolism</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Nuclear Respiratory Factor 1 - agonists</topic><topic>Nuclear Respiratory Factor 1 - genetics</topic><topic>Nuclear Respiratory Factor 1 - metabolism</topic><topic>Organelle Biogenesis</topic><topic>Performance-Enhancing Substances - administration & dosage</topic><topic>Performance-Enhancing Substances - adverse effects</topic><topic>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - agonists</topic><topic>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics</topic><topic>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism</topic><topic>Physical Endurance</topic><topic>PPAR gamma - agonists</topic><topic>PPAR gamma - genetics</topic><topic>PPAR gamma - metabolism</topic><topic>Random Allocation</topic><topic>Sirtuin 1 - chemistry</topic><topic>Sirtuin 1 - genetics</topic><topic>Sirtuin 1 - metabolism</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Yoo</creatorcontrib><creatorcontrib>Kim, Daeyoung</creatorcontrib><creatorcontrib>Park, Yeonhwa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutritional biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Yoo</au><au>Kim, Daeyoung</au><au>Park, Yeonhwa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conjugated linoleic acid (CLA) promotes endurance capacity via peroxisome proliferator-activated receptor δ-mediated mechanism in mice</atitle><jtitle>The Journal of nutritional biochemistry</jtitle><addtitle>J Nutr Biochem</addtitle><date>2016-12</date><risdate>2016</risdate><volume>38</volume><spage>125</spage><epage>133</epage><pages>125-133</pages><issn>0955-2863</issn><eissn>1873-4847</eissn><abstract>Previously, it was reported that conjugated linoleic acid (CLA) with exercise training potentially improved endurance capacity via the peroxisome proliferator-activated receptor δ (PPARδ)-mediated mechanism in mice. This study determined the role of exercise and/or CLA in endurance capacity and PPARδ-associated regulators. Male 129Sv/J mice were fed either control (soybean oil) or CLA (0.5%) containing diets for 4 weeks and were further divided into sedentary or training regimes. CLA supplementation significantly reduced body weight and fat mass independent of exercise during the experimental period. Endurance capacity was significantly improved by CLA supplementation, while no effect of exercise was observed. Similarly, CLA treatment significantly increased expressions of sirtuin 1 and PPARγ coactivator-1α, up-stream regulators of PPARδ, in both sedentary and trained animals. With respect to downstream markers of PPARδ, CLA up-regulated the key biomarker needed to stimulate mitochondrial biogenesis, nuclear respiratory factor 1. Moreover, CLA supplementation significantly induced overall genes associated with muscle fibers, such as type I (slow-twitch) and type II (fast twitch). Taken together, it suggests that CLA improves endurance capacity independent of mild-intensity exercise via PPARδ-mediated mechanism.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27736732</pmid><doi>10.1016/j.jnutbio.2016.08.005</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9727-0899</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adiposity Animals Biomarkers - metabolism CLA Conjugated linoleic acid Dietary Supplements - adverse effects Endurance capacity Energy Intake Energy Metabolism Gene Expression Regulation Linoleic Acids, Conjugated - administration & dosage Linoleic Acids, Conjugated - adverse effects Male Mice, 129 Strain Mitochondria, Muscle - metabolism Mitochondrial biogenesis Mitochondrial Dynamics Muscle metabolism Muscle, Skeletal - metabolism Nuclear Respiratory Factor 1 - agonists Nuclear Respiratory Factor 1 - genetics Nuclear Respiratory Factor 1 - metabolism Organelle Biogenesis Performance-Enhancing Substances - administration & dosage Performance-Enhancing Substances - adverse effects Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - agonists Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Physical Endurance PPAR gamma - agonists PPAR gamma - genetics PPAR gamma - metabolism Random Allocation Sirtuin 1 - chemistry Sirtuin 1 - genetics Sirtuin 1 - metabolism Weight Gain |
| title | Conjugated linoleic acid (CLA) promotes endurance capacity via peroxisome proliferator-activated receptor δ-mediated mechanism in mice |
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