Successful Strategies to Determine High-Resolution Structures of GPCRs

G protein-coupled receptors (GPCRs) constitute the largest class of drug targets in the human genome, which highlights the importance of understanding the molecular basis of their activation, downstream signaling, and regulation. Since 2007, great progress has been made in the field of GPCR structur...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2016-12, Vol.37 (12), p.1055-1069
Hauptverfasser:	Xiang, Jin, Chun, Eugene, Liu, Chang, Jing, Liang, Al-Sahouri, Zina, Zhu, Lan, Liu, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Crystallization Genome, Human GPCRs Humans ligand binding Ligands lipidic cubic phase Lipids - chemistry Protein Conformation protein engineering Protein Engineering - methods Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - metabolism Signal Transduction - physiology structure-based drug discovery
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