Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers

The liver and the small intestine are closely related in the processes of drug absorption, metabolism and excretion via the enterohepatic circulation. Small intestinal ulcers are a serious adverse effect commonly occurring in patients taking nonsteroidal anti‐inflammatory drugs. However, the influen...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2016-12, Vol.37 (9), p.522-532
Hauptverfasser:	Kawauchi, Shoji, Nakamura, Tsutomu, Horibe, Sayo, Tanahashi, Toshihito, Mizuno, Shigeto, Hamaguchi, Tsuneo, Rikitake, Yoshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - toxicity CYP3A Cytochrome P-450 CYP3A - biosynthesis Cytochrome P-450 CYP3A - genetics Disease Models, Animal Down-Regulation - drug effects Down-Regulation - physiology drug metabolism Gene Expression Regulation, Enzymologic Hep G2 Cells Humans Indomethacin Indomethacin - toxicity inflammatory mediators Intestine, Small - drug effects Intestine, Small - metabolism Intestine, Small - pathology Male Rats Rats, Sprague-Dawley small intestinal ulcer Ulcer - chemically induced Ulcer - metabolism Ulcer - pathology
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