Oral Delivery of a Nanocrystal Formulation of Schisantherin A with Improved Bioavailability and Brain Delivery for the Treatment of Parkinson’s Disease

Schisantherin A (SA) is a promising anti-Parkinsonism Chinese herbal medicine but with poor water solubility and challenges to be delivered to the brain. We formulated SA as nanocrystals (SA-NC), aiming to improve its solubility and pharmacokinetic profile and thus provide a potential therapeutic ag...

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Veröffentlicht in:	Molecular pharmaceutics 2016-11, Vol.13 (11), p.3864-3875
Hauptverfasser:	Chen, Tongkai, Li, Chuwen, Li, Ye, Yi, Xiang, Lee, Simon Ming-Yuen, Zheng, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Brain - drug effects Brain - metabolism Cyclooctanes - administration & dosage Cyclooctanes - chemistry Cyclooctanes - therapeutic use Dioxoles - administration & dosage Dioxoles - chemistry Dioxoles - therapeutic use Disease Models, Animal Drug Compounding - methods Lignans - administration & dosage Lignans - chemistry Lignans - therapeutic use Male Nanoparticles - chemistry Parkinson Disease - drug therapy Parkinson Disease - metabolism Rats, Sprague-Dawley Zebrafish
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