Cytokeratin 18 is necessary for initiation of TGF-β1-induced epithelial–mesenchymal transition in breast epithelial cells

During epithelial–mesenchymal transition (EMT), epithelial cells lose key phenotypic markers (e.g., E-cadherin and cytokeratin 18) and acquire mesenchymal markers (e.g., N -cadherin and vimentin). Although the loss of cytokeratin 18 is a hallmark of EMT, the regulatory role of cytokeratin 18 in EMT...

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Veröffentlicht in:	Molecular and cellular biochemistry 2016-12, Vol.423 (1-2), p.21-28
Hauptverfasser:	Jung, Hyejung, Kim, Bomin, Moon, Byung In, Oh, Eok-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Breast - cytology Breast - metabolism Cadherins - metabolism Cardiology Cell Line, Tumor Epithelial-Mesenchymal Transition Female Humans Keratin-18 - biosynthesis Life Sciences Medical Biochemistry Oncology Smad2 Protein - metabolism Smad3 Protein - metabolism Snail Family Transcription Factors - metabolism Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - pharmacology
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