Chronic FAAH inhibition during nicotine abstinence alters habenular CB1 receptor activity and precipitates depressive-like behaviors

The role of the endocannabinoid system in nicotine addiction is being increasingly acknowledged. Acute inhibition of anandamide (AEA) degradation efficiently reduces nicotine withdrawal-induced affective symptoms in rats and fatty acid amide hydrolase (FAAH), the degradation enzyme of AEA, has been...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuropharmacology 2017-02, Vol.113 (Pt A), p.252-259
Hauptverfasser:	Simonnet, A., Zamberletti, E., Cador, M., Rubino, T., Caillé, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abstinence Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Animals Benzamides - pharmacology Carbamates - pharmacology CB1 receptor Depression - metabolism Depression - psychology Depressive-like behavior Habenula Habenula - drug effects Habenula - metabolism Male Nicotine Nicotine - administration & dosage Rat Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB1 - metabolism Self Administration Substance Withdrawal Syndrome - metabolism Substance Withdrawal Syndrome - psychology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!