Insulin-like plant proteins as potential innovative drugs to treat diabetes—The Moringa oleifera case study
•Plant proteins with in vitro and in vivo insulin-mimetic effects.•Insulin-like proteins are found in leaves, fruits and seeds.•Insulin-like plant proteins have the potential for therapeutic use in diabetes.•Moringa oleifera is a source of insulin-like proteins. Various plant species have long been...
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| Veröffentlicht in: | New biotechnology 2017-10, Vol.39 (Pt A), p.99-109 |
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| creator | Paula, P.C. Oliveira, J.T.A. Sousa, D.O.B. Alves, B.G.T. Carvalho, A.F.U. Franco, O.L. Vasconcelos, I.M. |
| description | •Plant proteins with in vitro and in vivo insulin-mimetic effects.•Insulin-like proteins are found in leaves, fruits and seeds.•Insulin-like plant proteins have the potential for therapeutic use in diabetes.•Moringa oleifera is a source of insulin-like proteins.
Various plant species have long been used in traditional medicine worldwide to treat diabetes. Among the plant-based compounds with hypoglycemic properties, studies on insulin-like proteins isolated from leaves, fruits and seeds are rarely reported in the relevant literature. Our research group has been investigating the presence of insulin-like proteins in Moringa oleifera, a plant species native to India, and we have obtained a leaf protein isolate and semi-purified derived fractions, as well as a seed coat protein fraction (Mo-SC), with hypoglycemic activity in chemically induced diabetic mice that have increased tolerance to orally administered glucose. Equally importantly, Mo-SC possesses insulin-like antigenic epitopes. In this context, the present review aims to highlight that prospection of insulin-like proteins in plants is of the utmost importance both for finding new drugs for the treatment of diabetes and for shedding light on the mechanisms involved in diabetes. |
| doi_str_mv | 10.1016/j.nbt.2016.10.005 |
| format | Article |
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Various plant species have long been used in traditional medicine worldwide to treat diabetes. Among the plant-based compounds with hypoglycemic properties, studies on insulin-like proteins isolated from leaves, fruits and seeds are rarely reported in the relevant literature. Our research group has been investigating the presence of insulin-like proteins in Moringa oleifera, a plant species native to India, and we have obtained a leaf protein isolate and semi-purified derived fractions, as well as a seed coat protein fraction (Mo-SC), with hypoglycemic activity in chemically induced diabetic mice that have increased tolerance to orally administered glucose. Equally importantly, Mo-SC possesses insulin-like antigenic epitopes. In this context, the present review aims to highlight that prospection of insulin-like proteins in plants is of the utmost importance both for finding new drugs for the treatment of diabetes and for shedding light on the mechanisms involved in diabetes.</description><identifier>ISSN: 1871-6784</identifier><identifier>EISSN: 1876-4347</identifier><identifier>DOI: 10.1016/j.nbt.2016.10.005</identifier><identifier>PMID: 27737801</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Antigens ; Case studies ; Chemical activity ; Coat protein ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - drug therapy ; Diabetes therapy ; Drugs ; Epitopes ; Folk medicine ; Glucose tolerance ; Humans ; Hypoglycemic protein ; Immunological tolerance ; Indigenous species ; Insulin ; Insulin - chemistry ; Insulin - isolation & purification ; Insulin - therapeutic use ; Insulin-like plant protein ; Leaves ; Lectins - therapeutic use ; Medicinal plants ; Moringa ; Moringa oleifera ; Moringa oleifera - chemistry ; Oral administration ; Organic chemistry ; Plant Leaves - chemistry ; Plant Proteins - chemistry ; Plant Proteins - isolation & purification ; Plant Proteins - therapeutic use ; Plant species ; Prospection ; Proteins ; Seed coats ; Seeds</subject><ispartof>New biotechnology, 2017-10, Vol.39 (Pt A), p.99-109</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Oct 25, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-347e6588a21c505be228f6d11840e4334d5e5710538e5afa1dfa491fb444e9a33</citedby><cites>FETCH-LOGICAL-c461t-347e6588a21c505be228f6d11840e4334d5e5710538e5afa1dfa491fb444e9a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.nbt.2016.10.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27737801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paula, P.C.</creatorcontrib><creatorcontrib>Oliveira, J.T.A.</creatorcontrib><creatorcontrib>Sousa, D.O.B.</creatorcontrib><creatorcontrib>Alves, B.G.T.</creatorcontrib><creatorcontrib>Carvalho, A.F.U.</creatorcontrib><creatorcontrib>Franco, O.L.</creatorcontrib><creatorcontrib>Vasconcelos, I.M.</creatorcontrib><title>Insulin-like plant proteins as potential innovative drugs to treat diabetes—The Moringa oleifera case study</title><title>New biotechnology</title><addtitle>N Biotechnol</addtitle><description>•Plant proteins with in vitro and in vivo insulin-mimetic effects.•Insulin-like proteins are found in leaves, fruits and seeds.•Insulin-like plant proteins have the potential for therapeutic use in diabetes.•Moringa oleifera is a source of insulin-like proteins.
Various plant species have long been used in traditional medicine worldwide to treat diabetes. Among the plant-based compounds with hypoglycemic properties, studies on insulin-like proteins isolated from leaves, fruits and seeds are rarely reported in the relevant literature. Our research group has been investigating the presence of insulin-like proteins in Moringa oleifera, a plant species native to India, and we have obtained a leaf protein isolate and semi-purified derived fractions, as well as a seed coat protein fraction (Mo-SC), with hypoglycemic activity in chemically induced diabetic mice that have increased tolerance to orally administered glucose. Equally importantly, Mo-SC possesses insulin-like antigenic epitopes. In this context, the present review aims to highlight that prospection of insulin-like proteins in plants is of the utmost importance both for finding new drugs for the treatment of diabetes and for shedding light on the mechanisms involved in diabetes.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigens</subject><subject>Case studies</subject><subject>Chemical activity</subject><subject>Coat protein</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes therapy</subject><subject>Drugs</subject><subject>Epitopes</subject><subject>Folk medicine</subject><subject>Glucose tolerance</subject><subject>Humans</subject><subject>Hypoglycemic protein</subject><subject>Immunological tolerance</subject><subject>Indigenous species</subject><subject>Insulin</subject><subject>Insulin - chemistry</subject><subject>Insulin - isolation & purification</subject><subject>Insulin - therapeutic use</subject><subject>Insulin-like plant protein</subject><subject>Leaves</subject><subject>Lectins - therapeutic use</subject><subject>Medicinal plants</subject><subject>Moringa</subject><subject>Moringa oleifera</subject><subject>Moringa oleifera - chemistry</subject><subject>Oral administration</subject><subject>Organic chemistry</subject><subject>Plant Leaves - chemistry</subject><subject>Plant Proteins - chemistry</subject><subject>Plant Proteins - isolation & purification</subject><subject>Plant Proteins - therapeutic use</subject><subject>Plant species</subject><subject>Prospection</subject><subject>Proteins</subject><subject>Seed coats</subject><subject>Seeds</subject><issn>1871-6784</issn><issn>1876-4347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UctOHDEQtKIgXuEDcoks5ZLLLO4Z2-NRThEigATiQs6WZ9xDvJm1N7ZnJW58BF-YL8HLEg455NTVrepSdxUhH4EtgIE8XS58nxd1gaVfMCbekUNQrax4w9v3Lxgq2Sp-QI5SWjImoZOwTw7qtm1axeCQrK58mifnq8n9QrqejM90HUNG5xM1ia4L9NmZiTrvw8Zkt0Fq43yfaA40RzSZWmd6zJj-PD7d_UR6E6Lz94aGCd2I0dDBJKQpz_bhA9kbzZTw5LUekx_fz-_OLqvr24urs2_X1cAl5Kpcj1IoZWoYBBM91rUapQVQnCFvGm4FihaYaBQKMxqwo-EdjD3nHDvTNMfky063vPJ7xpT1yqUBp_IehjlpUI3gALJjhfr5H-oyzNGX63TNOlXM4-1WEHasIYaUIo56Hd3KxAcNTG-z0EtdstDbLLajkkXZ-fSqPPcrtG8bf80vhK87AhYrNg6jToNDP6B1EYesbXD_kX8Gixaa_w</recordid><startdate>20171025</startdate><enddate>20171025</enddate><creator>Paula, P.C.</creator><creator>Oliveira, J.T.A.</creator><creator>Sousa, D.O.B.</creator><creator>Alves, B.G.T.</creator><creator>Carvalho, A.F.U.</creator><creator>Franco, O.L.</creator><creator>Vasconcelos, I.M.</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20171025</creationdate><title>Insulin-like plant proteins as potential innovative drugs to treat diabetes—The Moringa oleifera case study</title><author>Paula, P.C. ; Oliveira, J.T.A. ; Sousa, D.O.B. ; Alves, B.G.T. ; Carvalho, A.F.U. ; Franco, O.L. ; Vasconcelos, I.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-347e6588a21c505be228f6d11840e4334d5e5710538e5afa1dfa491fb444e9a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antigens</topic><topic>Case studies</topic><topic>Chemical activity</topic><topic>Coat protein</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes therapy</topic><topic>Drugs</topic><topic>Epitopes</topic><topic>Folk medicine</topic><topic>Glucose tolerance</topic><topic>Humans</topic><topic>Hypoglycemic protein</topic><topic>Immunological tolerance</topic><topic>Indigenous species</topic><topic>Insulin</topic><topic>Insulin - chemistry</topic><topic>Insulin - isolation & purification</topic><topic>Insulin - therapeutic use</topic><topic>Insulin-like plant protein</topic><topic>Leaves</topic><topic>Lectins - therapeutic use</topic><topic>Medicinal plants</topic><topic>Moringa</topic><topic>Moringa oleifera</topic><topic>Moringa oleifera - chemistry</topic><topic>Oral administration</topic><topic>Organic chemistry</topic><topic>Plant Leaves - chemistry</topic><topic>Plant Proteins - chemistry</topic><topic>Plant Proteins - isolation & purification</topic><topic>Plant Proteins - therapeutic use</topic><topic>Plant species</topic><topic>Prospection</topic><topic>Proteins</topic><topic>Seed coats</topic><topic>Seeds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paula, P.C.</creatorcontrib><creatorcontrib>Oliveira, J.T.A.</creatorcontrib><creatorcontrib>Sousa, D.O.B.</creatorcontrib><creatorcontrib>Alves, B.G.T.</creatorcontrib><creatorcontrib>Carvalho, A.F.U.</creatorcontrib><creatorcontrib>Franco, O.L.</creatorcontrib><creatorcontrib>Vasconcelos, I.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>New biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paula, P.C.</au><au>Oliveira, J.T.A.</au><au>Sousa, D.O.B.</au><au>Alves, B.G.T.</au><au>Carvalho, A.F.U.</au><au>Franco, O.L.</au><au>Vasconcelos, I.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin-like plant proteins as potential innovative drugs to treat diabetes—The Moringa oleifera case study</atitle><jtitle>New biotechnology</jtitle><addtitle>N Biotechnol</addtitle><date>2017-10-25</date><risdate>2017</risdate><volume>39</volume><issue>Pt A</issue><spage>99</spage><epage>109</epage><pages>99-109</pages><issn>1871-6784</issn><eissn>1876-4347</eissn><abstract>•Plant proteins with in vitro and in vivo insulin-mimetic effects.•Insulin-like proteins are found in leaves, fruits and seeds.•Insulin-like plant proteins have the potential for therapeutic use in diabetes.•Moringa oleifera is a source of insulin-like proteins.
Various plant species have long been used in traditional medicine worldwide to treat diabetes. Among the plant-based compounds with hypoglycemic properties, studies on insulin-like proteins isolated from leaves, fruits and seeds are rarely reported in the relevant literature. Our research group has been investigating the presence of insulin-like proteins in Moringa oleifera, a plant species native to India, and we have obtained a leaf protein isolate and semi-purified derived fractions, as well as a seed coat protein fraction (Mo-SC), with hypoglycemic activity in chemically induced diabetic mice that have increased tolerance to orally administered glucose. Equally importantly, Mo-SC possesses insulin-like antigenic epitopes. In this context, the present review aims to highlight that prospection of insulin-like proteins in plants is of the utmost importance both for finding new drugs for the treatment of diabetes and for shedding light on the mechanisms involved in diabetes.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27737801</pmid><doi>10.1016/j.nbt.2016.10.005</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | New biotechnology, 2017-10, Vol.39 (Pt A), p.99-109 |
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| subjects | Amino Acid Sequence Animals Antigens Case studies Chemical activity Coat protein Diabetes Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes therapy Drugs Epitopes Folk medicine Glucose tolerance Humans Hypoglycemic protein Immunological tolerance Indigenous species Insulin Insulin - chemistry Insulin - isolation & purification Insulin - therapeutic use Insulin-like plant protein Leaves Lectins - therapeutic use Medicinal plants Moringa Moringa oleifera Moringa oleifera - chemistry Oral administration Organic chemistry Plant Leaves - chemistry Plant Proteins - chemistry Plant Proteins - isolation & purification Plant Proteins - therapeutic use Plant species Prospection Proteins Seed coats Seeds |
| title | Insulin-like plant proteins as potential innovative drugs to treat diabetes—The Moringa oleifera case study |
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