Analysis of relation between hypoxia PET imaging and tissue-based biomarkers during head and neck radiochemotherapy
Tumor hypoxia is associated with poor prognosis and outcome and can be visualized using 18F-MISO-positron emission tomography (PET) imaging. The goal of this study was to evaluate the correlation between biological markers and biological imaging in a group of patients in whom a correlation between b...
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| Veröffentlicht in: | Acta oncologica 2016-11, Vol.55 (11), p.1299-1304 |
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| creator | Bittner, Martin-Immanuel Wiedenmann, Nicole Bucher, Sabine Hentschel, Michael Mix, Michael Rücker, Gerta Weber, Wolfgang A Meyer, Philipp T Werner, Martin Grosu, Anca-Ligia Kayser, Gian |
| description | Tumor hypoxia is associated with poor prognosis and outcome and can be visualized using 18F-MISO-positron emission tomography (PET) imaging. The goal of this study was to evaluate the correlation between biological markers and biological imaging in a group of patients in whom a correlation between biological imaging and outcome has previously been demonstrated.
In a prospective pilot project, 16 patients with locally advanced cancer of the head and neck underwent 18F-MISO-PET scans before and during primary radiochemotherapy in addition to 18F-FDG-PET and computed tomography (CT). Tumor biopsies were stained for three tissue-based markers (Ku80, CAIX, CD44); in addition, human papillomavirus (HPV) status was assessed. H-scores of marker expression were generated and the results were correlated with the biological imaging and clinical outcome.
No statistically significant correlation was established between the H-scores for Ku80, CD44 and CAIX or between any of the H-scores and the imaging variables (tumor volume on 18F-FDG-PET in ml, hypoxic subvolume as assessed by 18F-MISO-PET in ml, and SUVmax tumor/SUVmean muscle during the 18F-MISO-PET). A statistically significant negative correlation was found between CD44 H-score and HPV status (p = .004). Cox regression analysis for overall survival and recurrence-free survival showed one significant result for CAIX being associated with improved overall survival [hazard ratio 0.96 (0.93-1.00), p = .047].
Expression of Ku80, CAIX and CD44 as assessed by immunohistochemistry of tumor biopsies were not correlated to one another or the biological imaging data. However, there was a significant influence of CAIX on overall survival and between CD44 and HPV. |
| doi_str_mv | 10.1080/0284186x.2016.1219046 |
| format | Article |
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In a prospective pilot project, 16 patients with locally advanced cancer of the head and neck underwent 18F-MISO-PET scans before and during primary radiochemotherapy in addition to 18F-FDG-PET and computed tomography (CT). Tumor biopsies were stained for three tissue-based markers (Ku80, CAIX, CD44); in addition, human papillomavirus (HPV) status was assessed. H-scores of marker expression were generated and the results were correlated with the biological imaging and clinical outcome.
No statistically significant correlation was established between the H-scores for Ku80, CD44 and CAIX or between any of the H-scores and the imaging variables (tumor volume on 18F-FDG-PET in ml, hypoxic subvolume as assessed by 18F-MISO-PET in ml, and SUVmax tumor/SUVmean muscle during the 18F-MISO-PET). A statistically significant negative correlation was found between CD44 H-score and HPV status (p = .004). Cox regression analysis for overall survival and recurrence-free survival showed one significant result for CAIX being associated with improved overall survival [hazard ratio 0.96 (0.93-1.00), p = .047].
Expression of Ku80, CAIX and CD44 as assessed by immunohistochemistry of tumor biopsies were not correlated to one another or the biological imaging data. However, there was a significant influence of CAIX on overall survival and between CD44 and HPV.</description><identifier>ISSN: 0284-186X</identifier><identifier>EISSN: 1651-226X</identifier><identifier>DOI: 10.1080/0284186x.2016.1219046</identifier><identifier>PMID: 27593107</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - metabolism ; Carbonic Anhydrase IX - analysis ; Carbonic Anhydrase IX - metabolism ; Carcinoma, Squamous Cell - diagnostic imaging ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - therapy ; Chemoradiotherapy - methods ; Fluorodeoxyglucose F18 ; Head and Neck Neoplasms - diagnostic imaging ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - therapy ; Humans ; Hyaluronan Receptors - analysis ; Hyaluronan Receptors - metabolism ; Immunohistochemistry ; Ku Autoantigen - analysis ; Ku Autoantigen - metabolism ; Male ; Middle Aged ; Misonidazole - analogs & derivatives ; Papillomavirus Infections - etiology ; Positron-Emission Tomography - methods ; Proportional Hazards Models ; Radiopharmaceuticals ; Tomography, X-Ray Computed - methods ; Tumor Hypoxia</subject><ispartof>Acta oncologica, 2016-11, Vol.55 (11), p.1299-1304</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-404728890ab9b43931616e7f377886b88832994146c7f0f03d045044962d94d93</citedby><cites>FETCH-LOGICAL-c422t-404728890ab9b43931616e7f377886b88832994146c7f0f03d045044962d94d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27593107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bittner, Martin-Immanuel</creatorcontrib><creatorcontrib>Wiedenmann, Nicole</creatorcontrib><creatorcontrib>Bucher, Sabine</creatorcontrib><creatorcontrib>Hentschel, Michael</creatorcontrib><creatorcontrib>Mix, Michael</creatorcontrib><creatorcontrib>Rücker, Gerta</creatorcontrib><creatorcontrib>Weber, Wolfgang A</creatorcontrib><creatorcontrib>Meyer, Philipp T</creatorcontrib><creatorcontrib>Werner, Martin</creatorcontrib><creatorcontrib>Grosu, Anca-Ligia</creatorcontrib><creatorcontrib>Kayser, Gian</creatorcontrib><title>Analysis of relation between hypoxia PET imaging and tissue-based biomarkers during head and neck radiochemotherapy</title><title>Acta oncologica</title><addtitle>Acta Oncol</addtitle><description>Tumor hypoxia is associated with poor prognosis and outcome and can be visualized using 18F-MISO-positron emission tomography (PET) imaging. The goal of this study was to evaluate the correlation between biological markers and biological imaging in a group of patients in whom a correlation between biological imaging and outcome has previously been demonstrated.
In a prospective pilot project, 16 patients with locally advanced cancer of the head and neck underwent 18F-MISO-PET scans before and during primary radiochemotherapy in addition to 18F-FDG-PET and computed tomography (CT). Tumor biopsies were stained for three tissue-based markers (Ku80, CAIX, CD44); in addition, human papillomavirus (HPV) status was assessed. H-scores of marker expression were generated and the results were correlated with the biological imaging and clinical outcome.
No statistically significant correlation was established between the H-scores for Ku80, CD44 and CAIX or between any of the H-scores and the imaging variables (tumor volume on 18F-FDG-PET in ml, hypoxic subvolume as assessed by 18F-MISO-PET in ml, and SUVmax tumor/SUVmean muscle during the 18F-MISO-PET). A statistically significant negative correlation was found between CD44 H-score and HPV status (p = .004). Cox regression analysis for overall survival and recurrence-free survival showed one significant result for CAIX being associated with improved overall survival [hazard ratio 0.96 (0.93-1.00), p = .047].
Expression of Ku80, CAIX and CD44 as assessed by immunohistochemistry of tumor biopsies were not correlated to one another or the biological imaging data. However, there was a significant influence of CAIX on overall survival and between CD44 and HPV.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carbonic Anhydrase IX - analysis</subject><subject>Carbonic Anhydrase IX - metabolism</subject><subject>Carcinoma, Squamous Cell - diagnostic imaging</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Chemoradiotherapy - methods</subject><subject>Fluorodeoxyglucose F18</subject><subject>Head and Neck Neoplasms - diagnostic imaging</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Hyaluronan Receptors - analysis</subject><subject>Hyaluronan Receptors - metabolism</subject><subject>Immunohistochemistry</subject><subject>Ku Autoantigen - analysis</subject><subject>Ku Autoantigen - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Misonidazole - analogs & derivatives</subject><subject>Papillomavirus Infections - etiology</subject><subject>Positron-Emission Tomography - methods</subject><subject>Proportional Hazards Models</subject><subject>Radiopharmaceuticals</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Tumor Hypoxia</subject><issn>0284-186X</issn><issn>1651-226X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtu2zAQRYmgQewm-YQUXHYjd_gQH0vDSB-AgWaRAN4JlDiK2UiiS0pI_PeVG7er2Zx7Z-YQcsdgxcDAF-BGMqPeVhyYWjHOLEh1QZZMlazgXO0-kOWJKWZotyAfc_4FAFzo8oosuC6tYKCXJK8H1x1zyDS2NGHnxhAHWuP4ijjQ_fEQ34KjD_ePNPTuOQzP1A2ejiHnCYvaZfS0DrF36QVTpn5KJ2SPzv_lBmxeaHI-xGaPfRz3mNzheEMuW9dlvD3Pa_L09f5x873Y_vz2Y7PeFo3kfCwkSM2NseBqW0sxH6yYQt0KrY1RtTFGcGslk6rRLbQgPMgSpLSKeyu9Fdfk83vvIcXfE-ax6kNusOvcgHHKFTOilKBZqWa0fEebFHNO2FaHND-cjhWD6uS7OvveVSff1dn3nPt0XjHVPfr_qX-CxR9qQXsI</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Bittner, Martin-Immanuel</creator><creator>Wiedenmann, Nicole</creator><creator>Bucher, Sabine</creator><creator>Hentschel, Michael</creator><creator>Mix, Michael</creator><creator>Rücker, Gerta</creator><creator>Weber, Wolfgang A</creator><creator>Meyer, Philipp T</creator><creator>Werner, Martin</creator><creator>Grosu, Anca-Ligia</creator><creator>Kayser, Gian</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Analysis of relation between hypoxia PET imaging and tissue-based biomarkers during head and neck radiochemotherapy</title><author>Bittner, Martin-Immanuel ; Wiedenmann, Nicole ; Bucher, Sabine ; Hentschel, Michael ; Mix, Michael ; Rücker, Gerta ; Weber, Wolfgang A ; Meyer, Philipp T ; Werner, Martin ; Grosu, Anca-Ligia ; Kayser, Gian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-404728890ab9b43931616e7f377886b88832994146c7f0f03d045044962d94d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carbonic Anhydrase IX - analysis</topic><topic>Carbonic Anhydrase IX - metabolism</topic><topic>Carcinoma, Squamous Cell - diagnostic imaging</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Chemoradiotherapy - methods</topic><topic>Fluorodeoxyglucose F18</topic><topic>Head and Neck Neoplasms - diagnostic imaging</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Hyaluronan Receptors - analysis</topic><topic>Hyaluronan Receptors - metabolism</topic><topic>Immunohistochemistry</topic><topic>Ku Autoantigen - analysis</topic><topic>Ku Autoantigen - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Misonidazole - analogs & derivatives</topic><topic>Papillomavirus Infections - etiology</topic><topic>Positron-Emission Tomography - methods</topic><topic>Proportional Hazards Models</topic><topic>Radiopharmaceuticals</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Tumor Hypoxia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bittner, Martin-Immanuel</creatorcontrib><creatorcontrib>Wiedenmann, Nicole</creatorcontrib><creatorcontrib>Bucher, Sabine</creatorcontrib><creatorcontrib>Hentschel, Michael</creatorcontrib><creatorcontrib>Mix, Michael</creatorcontrib><creatorcontrib>Rücker, Gerta</creatorcontrib><creatorcontrib>Weber, Wolfgang A</creatorcontrib><creatorcontrib>Meyer, Philipp T</creatorcontrib><creatorcontrib>Werner, Martin</creatorcontrib><creatorcontrib>Grosu, Anca-Ligia</creatorcontrib><creatorcontrib>Kayser, Gian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta oncologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bittner, Martin-Immanuel</au><au>Wiedenmann, Nicole</au><au>Bucher, Sabine</au><au>Hentschel, Michael</au><au>Mix, Michael</au><au>Rücker, Gerta</au><au>Weber, Wolfgang A</au><au>Meyer, Philipp T</au><au>Werner, Martin</au><au>Grosu, Anca-Ligia</au><au>Kayser, Gian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of relation between hypoxia PET imaging and tissue-based biomarkers during head and neck radiochemotherapy</atitle><jtitle>Acta oncologica</jtitle><addtitle>Acta Oncol</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>55</volume><issue>11</issue><spage>1299</spage><epage>1304</epage><pages>1299-1304</pages><issn>0284-186X</issn><eissn>1651-226X</eissn><abstract>Tumor hypoxia is associated with poor prognosis and outcome and can be visualized using 18F-MISO-positron emission tomography (PET) imaging. The goal of this study was to evaluate the correlation between biological markers and biological imaging in a group of patients in whom a correlation between biological imaging and outcome has previously been demonstrated.
In a prospective pilot project, 16 patients with locally advanced cancer of the head and neck underwent 18F-MISO-PET scans before and during primary radiochemotherapy in addition to 18F-FDG-PET and computed tomography (CT). Tumor biopsies were stained for three tissue-based markers (Ku80, CAIX, CD44); in addition, human papillomavirus (HPV) status was assessed. H-scores of marker expression were generated and the results were correlated with the biological imaging and clinical outcome.
No statistically significant correlation was established between the H-scores for Ku80, CD44 and CAIX or between any of the H-scores and the imaging variables (tumor volume on 18F-FDG-PET in ml, hypoxic subvolume as assessed by 18F-MISO-PET in ml, and SUVmax tumor/SUVmean muscle during the 18F-MISO-PET). A statistically significant negative correlation was found between CD44 H-score and HPV status (p = .004). Cox regression analysis for overall survival and recurrence-free survival showed one significant result for CAIX being associated with improved overall survival [hazard ratio 0.96 (0.93-1.00), p = .047].
Expression of Ku80, CAIX and CD44 as assessed by immunohistochemistry of tumor biopsies were not correlated to one another or the biological imaging data. However, there was a significant influence of CAIX on overall survival and between CD44 and HPV.</abstract><cop>England</cop><pmid>27593107</pmid><doi>10.1080/0284186x.2016.1219046</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Taylor & Francis Journals Complete; Alma/SFX Local Collection |
| subjects | Adult Aged Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Carbonic Anhydrase IX - analysis Carbonic Anhydrase IX - metabolism Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - therapy Chemoradiotherapy - methods Fluorodeoxyglucose F18 Head and Neck Neoplasms - diagnostic imaging Head and Neck Neoplasms - mortality Head and Neck Neoplasms - therapy Humans Hyaluronan Receptors - analysis Hyaluronan Receptors - metabolism Immunohistochemistry Ku Autoantigen - analysis Ku Autoantigen - metabolism Male Middle Aged Misonidazole - analogs & derivatives Papillomavirus Infections - etiology Positron-Emission Tomography - methods Proportional Hazards Models Radiopharmaceuticals Tomography, X-Ray Computed - methods Tumor Hypoxia |
| title | Analysis of relation between hypoxia PET imaging and tissue-based biomarkers during head and neck radiochemotherapy |
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