GYY4137 ameliorates intestinal barrier injury in a mouse model of endotoxemia

[Display omitted] Intestinal barrier injury has been reported to play a vital role in the pathogenesis of endotoxemia. This study aimed to investigate the protective effect of GYY4137, a newly synthesized H2S donor, on the intestinal barrier function in the context of endotoxemia both in vitro and i...

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Veröffentlicht in:	Biochemical pharmacology 2016-10, Vol.118, p.59-67
Hauptverfasser:	Chen, Shanwen, Bu, Dingfang, Ma, Yuanyuan, Zhu, Jing, Sun, Lie, Zuo, Shuai, Ma, Ju, Li, Tengyu, Chen, Zeyang, Zheng, Youwen, Wang, Xin, Pan, Yisheng, Wang, Pengyuan, Liu, Yucun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Caco-2 Cells Cell Membrane Permeability Disease Models, Animal Electric Impedance Endotoxemia - drug therapy Endotoxemia - immunology Endotoxemia - pathology Endotoxemia - physiopathology Enterocytes - drug effects Enterocytes - immunology Enterocytes - metabolism Enterocytes - ultrastructure Gastrointestinal Agents - pharmacology Gastrointestinal Agents - therapeutic use Gene Expression Regulation - drug effects GYY4137 Humans Hydrogen sulfide Interferon-gamma - antagonists & inhibitors Interferon-gamma - metabolism Intestinal Mucosa - drug effects Intestinal Mucosa - immunology Intestinal Mucosa - physiopathology Intestinal Mucosa - ultrastructure Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - toxicity LPS Male Mice, Inbred C57BL Morpholines - pharmacology Morpholines - therapeutic use NF-kB Organothiophosphorus Compounds - pharmacology Organothiophosphorus Compounds - therapeutic use Protective Agents - pharmacology Protective Agents - therapeutic use Random Allocation Tight junction Tight Junction Proteins - genetics Tight Junction Proteins - metabolism Tight Junctions - drug effects Tight Junctions - immunology Tight Junctions - metabolism Tight Junctions - ultrastructure Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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