DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis

Effective and rapid bacterial clearance is a fundamental determinant of outcomes in sepsis. DJ-1 is a well-established reactive oxygen species (ROS) scavenger. Because cellular ROS status is pivotal to inflammation and bacterial killing, we determined the role of DJ-1 in bacterial sepsis. We used ce...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2017-04, Vol.195 (7), p.889-905
Hauptverfasser:	Amatullah, Hajera, Shan, Yuexin, Beauchamp, Brittany L, Gali, Patricia L, Gupta, Sahil, Maron-Gutierrez, Tatiana, Speck, Edwin R, Fox-Robichaud, Alison E, Tsang, Jennifer L Y, Mei, Shirley H J, Mak, Tak W, Rocco, Patricia R M, Semple, John W, Zhang, Haibo, Hu, Pingzhao, Marshall, John C, Stewart, Duncan J, Harper, Mary-Ellen, Liaw, Patricia C, Liles, W Conrad, Dos Santos, Claudia C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Humans Male Mice Protein Deglycase DJ-1 - blood Reactive Oxygen Species - blood Sepsis - blood
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