Facial Nerve Schwannomas: Review of 80 Cases Over 25 Years at Mayo Clinic

Abstract Objective To elucidate the long-term clinical behavior, treatment, and outcomes of sporadic facial nerve schwannoma (FNS) in a large cohort of patients managed in the post–magnetic resonance imaging era. Patients and Methods Retrospective review at a single tertiary health care system (Janu...

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Veröffentlicht in:Mayo Clinic proceedings 2016-11, Vol.91 (11), p.1563-1576
Hauptverfasser: Carlson, Matthew L., MD, Deep, Nicholas L., MD, Patel, Neil S., MD, Lundy, Larry B., MD, Tombers, Nicole M., RN, Lohse, Christine M., MS, Link, Michael J., MD, Driscoll, Colin L., MD
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container_end_page 1576
container_issue 11
container_start_page 1563
container_title Mayo Clinic proceedings
container_volume 91
creator Carlson, Matthew L., MD
Deep, Nicholas L., MD
Patel, Neil S., MD
Lundy, Larry B., MD
Tombers, Nicole M., RN
Lohse, Christine M., MS
Link, Michael J., MD
Driscoll, Colin L., MD
description Abstract Objective To elucidate the long-term clinical behavior, treatment, and outcomes of sporadic facial nerve schwannoma (FNS) in a large cohort of patients managed in the post–magnetic resonance imaging era. Patients and Methods Retrospective review at a single tertiary health care system (January 1, 1990, through December 31, 2015), evaluating 80 consecutive patients with sporadic FNS. Results Ninety-eight patients with FNS were identified; 10 with incomplete data and 8 with neurofibromatosis type 2 were excluded. The remaining 80 patients (median age, 47 years; 58% women) were analyzed. Forty-three (54%) patients presented with asymmetrical hearing loss, 33 (41%) reported facial paresis, and 21 (26%) reported facial spasm. Seventeen (21%) exhibited radiologic features mimicking vestibular schwannoma, 14 (18%) presented as a parotid mass, and 5 (6%) were discovered incidentally. Factors predictive of facial nerve paresis or spasm before treatment were female sex and tumor involvement of the labyrinthine/geniculate and tympanic facial nerve segments. The median growth rate among growing FNS was 2.0 mm/y. Details regarding clinical outcome according to treatment modality are described. Conclusion In patients with FNS, female sex and involvement of the labyrinthine/geniculate and tympanic segments of the facial nerve predict a higher probability of facial paresis or spasm. When isolated to the posterior fossa or parotid gland, establishing a preoperative diagnosis of FNS is challenging. Treatment should be tailored according to tumor location and size, existing facial nerve function, patient priorities, and age. A management algorithm is presented, prioritizing long-term facial nerve function.
doi_str_mv 10.1016/j.mayocp.2016.07.007
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Patients and Methods Retrospective review at a single tertiary health care system (January 1, 1990, through December 31, 2015), evaluating 80 consecutive patients with sporadic FNS. Results Ninety-eight patients with FNS were identified; 10 with incomplete data and 8 with neurofibromatosis type 2 were excluded. The remaining 80 patients (median age, 47 years; 58% women) were analyzed. Forty-three (54%) patients presented with asymmetrical hearing loss, 33 (41%) reported facial paresis, and 21 (26%) reported facial spasm. Seventeen (21%) exhibited radiologic features mimicking vestibular schwannoma, 14 (18%) presented as a parotid mass, and 5 (6%) were discovered incidentally. Factors predictive of facial nerve paresis or spasm before treatment were female sex and tumor involvement of the labyrinthine/geniculate and tympanic facial nerve segments. The median growth rate among growing FNS was 2.0 mm/y. Details regarding clinical outcome according to treatment modality are described. Conclusion In patients with FNS, female sex and involvement of the labyrinthine/geniculate and tympanic segments of the facial nerve predict a higher probability of facial paresis or spasm. When isolated to the posterior fossa or parotid gland, establishing a preoperative diagnosis of FNS is challenging. Treatment should be tailored according to tumor location and size, existing facial nerve function, patient priorities, and age. A management algorithm is presented, prioritizing long-term facial nerve function.</description><identifier>ISSN: 0025-6196</identifier><identifier>EISSN: 1942-5546</identifier><identifier>DOI: 10.1016/j.mayocp.2016.07.007</identifier><identifier>PMID: 27720200</identifier><identifier>CODEN: MACPAJ</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cranial Nerve Neoplasms - diagnosis ; Cranial Nerve Neoplasms - therapy ; Diagnosis, Differential ; Dizziness - etiology ; Facial Nerve Diseases - diagnosis ; Facial Nerve Diseases - therapy ; Facial Paralysis - etiology ; Female ; Headache - etiology ; Hearing Loss - etiology ; Hemifacial Spasm - etiology ; Humans ; Incidental Findings ; Internal Medicine ; Male ; Middle Aged ; Minnesota ; Neurilemmoma - diagnosis ; Neurilemmoma - therapy ; Paralysis ; Patient Outcome Assessment ; Retrospective Studies ; Schwann cells ; Tinnitus - etiology ; Young Adult</subject><ispartof>Mayo Clinic proceedings, 2016-11, Vol.91 (11), p.1563-1576</ispartof><rights>Mayo Foundation for Medical Education and Research</rights><rights>2016 Mayo Foundation for Medical Education and Research</rights><rights>Copyright © 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.</rights><rights>COPYRIGHT 2016 Frontline Medical Communications Inc.</rights><rights>Copyright Mayo Foundation for Medical Education and Research Nov 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-cc6771069ec2f798829fb3f3800622d5b69ca1c8f2695c8c58bdc613d4562a03</citedby><cites>FETCH-LOGICAL-c581t-cc6771069ec2f798829fb3f3800622d5b69ca1c8f2695c8c58bdc613d4562a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27720200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carlson, Matthew L., MD</creatorcontrib><creatorcontrib>Deep, Nicholas L., MD</creatorcontrib><creatorcontrib>Patel, Neil S., MD</creatorcontrib><creatorcontrib>Lundy, Larry B., MD</creatorcontrib><creatorcontrib>Tombers, Nicole M., RN</creatorcontrib><creatorcontrib>Lohse, Christine M., MS</creatorcontrib><creatorcontrib>Link, Michael J., MD</creatorcontrib><creatorcontrib>Driscoll, Colin L., MD</creatorcontrib><title>Facial Nerve Schwannomas: Review of 80 Cases Over 25 Years at Mayo Clinic</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>Abstract Objective To elucidate the long-term clinical behavior, treatment, and outcomes of sporadic facial nerve schwannoma (FNS) in a large cohort of patients managed in the post–magnetic resonance imaging era. Patients and Methods Retrospective review at a single tertiary health care system (January 1, 1990, through December 31, 2015), evaluating 80 consecutive patients with sporadic FNS. Results Ninety-eight patients with FNS were identified; 10 with incomplete data and 8 with neurofibromatosis type 2 were excluded. The remaining 80 patients (median age, 47 years; 58% women) were analyzed. Forty-three (54%) patients presented with asymmetrical hearing loss, 33 (41%) reported facial paresis, and 21 (26%) reported facial spasm. Seventeen (21%) exhibited radiologic features mimicking vestibular schwannoma, 14 (18%) presented as a parotid mass, and 5 (6%) were discovered incidentally. Factors predictive of facial nerve paresis or spasm before treatment were female sex and tumor involvement of the labyrinthine/geniculate and tympanic facial nerve segments. The median growth rate among growing FNS was 2.0 mm/y. Details regarding clinical outcome according to treatment modality are described. Conclusion In patients with FNS, female sex and involvement of the labyrinthine/geniculate and tympanic segments of the facial nerve predict a higher probability of facial paresis or spasm. When isolated to the posterior fossa or parotid gland, establishing a preoperative diagnosis of FNS is challenging. Treatment should be tailored according to tumor location and size, existing facial nerve function, patient priorities, and age. A management algorithm is presented, prioritizing long-term facial nerve function.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cranial Nerve Neoplasms - diagnosis</subject><subject>Cranial Nerve Neoplasms - therapy</subject><subject>Diagnosis, Differential</subject><subject>Dizziness - etiology</subject><subject>Facial Nerve Diseases - diagnosis</subject><subject>Facial Nerve Diseases - therapy</subject><subject>Facial Paralysis - etiology</subject><subject>Female</subject><subject>Headache - etiology</subject><subject>Hearing Loss - etiology</subject><subject>Hemifacial Spasm - etiology</subject><subject>Humans</subject><subject>Incidental Findings</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minnesota</subject><subject>Neurilemmoma - diagnosis</subject><subject>Neurilemmoma - therapy</subject><subject>Paralysis</subject><subject>Patient Outcome Assessment</subject><subject>Retrospective Studies</subject><subject>Schwann cells</subject><subject>Tinnitus - etiology</subject><subject>Young Adult</subject><issn>0025-6196</issn><issn>1942-5546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk9v1DAQxS0EotvCN0DIEhLikmA7tpNwQKpWFCoVKtFeOFneyYT1ksRbO7vVfvs6pPzrBflg2fq98fO8IeQFZzlnXL_d5L09eNjmIp1yVuaMlY_IgtdSZEpJ_ZgsGBMq07zWR-Q4xg1LRF3Lp-RIlKVggrEFOT-z4GxHv2DYI72C9a0dBt_b-I5-xb3DW-pbWjG6tBEjvdxjoELRb2hDpHakn5MFuuzc4OAZedLaLuLz-_2EXJ99uF5-yi4uP54vTy8yUBUfMwBdlpzpGkG0ZV1Vom5XRVtUjGkhGrXSNVgOVSt0raBKolUDmheNVFpYVpyQN3PZbfA3O4yj6V0E7Do7oN9Fw6tCyfTxSib01QN043dhSOYmquRKKzlR-Ux9tx0aN7R-DBbSarB34AdsXbo_laWQRbJeJMHrvwRrtN24jr7bjc4P8V9QziAEH2PA1myD6204GM7MlKHZmDlDM2VoWGlSQkn28t72btVj81v0K7QEvJ8BTG1OGQUTweEA2LiAMJrGu_-98LAA_IzQdj_wgPFPl0wUhpmraY6mMeK6YDLFVNwBua--dQ</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Carlson, Matthew L., MD</creator><creator>Deep, Nicholas L., MD</creator><creator>Patel, Neil S., MD</creator><creator>Lundy, Larry B., MD</creator><creator>Tombers, Nicole M., RN</creator><creator>Lohse, Christine M., MS</creator><creator>Link, Michael J., MD</creator><creator>Driscoll, Colin L., MD</creator><general>Elsevier Inc</general><general>Frontline Medical Communications Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Facial Nerve Schwannomas: Review of 80 Cases Over 25 Years at Mayo Clinic</title><author>Carlson, Matthew L., MD ; 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Patients and Methods Retrospective review at a single tertiary health care system (January 1, 1990, through December 31, 2015), evaluating 80 consecutive patients with sporadic FNS. Results Ninety-eight patients with FNS were identified; 10 with incomplete data and 8 with neurofibromatosis type 2 were excluded. The remaining 80 patients (median age, 47 years; 58% women) were analyzed. Forty-three (54%) patients presented with asymmetrical hearing loss, 33 (41%) reported facial paresis, and 21 (26%) reported facial spasm. Seventeen (21%) exhibited radiologic features mimicking vestibular schwannoma, 14 (18%) presented as a parotid mass, and 5 (6%) were discovered incidentally. Factors predictive of facial nerve paresis or spasm before treatment were female sex and tumor involvement of the labyrinthine/geniculate and tympanic facial nerve segments. The median growth rate among growing FNS was 2.0 mm/y. Details regarding clinical outcome according to treatment modality are described. Conclusion In patients with FNS, female sex and involvement of the labyrinthine/geniculate and tympanic segments of the facial nerve predict a higher probability of facial paresis or spasm. When isolated to the posterior fossa or parotid gland, establishing a preoperative diagnosis of FNS is challenging. Treatment should be tailored according to tumor location and size, existing facial nerve function, patient priorities, and age. A management algorithm is presented, prioritizing long-term facial nerve function.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>27720200</pmid><doi>10.1016/j.mayocp.2016.07.007</doi><tpages>14</tpages></addata></record>
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subjects Adolescent
Adult
Aged
Aged, 80 and over
Cranial Nerve Neoplasms - diagnosis
Cranial Nerve Neoplasms - therapy
Diagnosis, Differential
Dizziness - etiology
Facial Nerve Diseases - diagnosis
Facial Nerve Diseases - therapy
Facial Paralysis - etiology
Female
Headache - etiology
Hearing Loss - etiology
Hemifacial Spasm - etiology
Humans
Incidental Findings
Internal Medicine
Male
Middle Aged
Minnesota
Neurilemmoma - diagnosis
Neurilemmoma - therapy
Paralysis
Patient Outcome Assessment
Retrospective Studies
Schwann cells
Tinnitus - etiology
Young Adult
title Facial Nerve Schwannomas: Review of 80 Cases Over 25 Years at Mayo Clinic
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