Facial Nerve Schwannomas: Review of 80 Cases Over 25 Years at Mayo Clinic
Abstract Objective To elucidate the long-term clinical behavior, treatment, and outcomes of sporadic facial nerve schwannoma (FNS) in a large cohort of patients managed in the post–magnetic resonance imaging era. Patients and Methods Retrospective review at a single tertiary health care system (Janu...
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description | Abstract Objective To elucidate the long-term clinical behavior, treatment, and outcomes of sporadic facial nerve schwannoma (FNS) in a large cohort of patients managed in the post–magnetic resonance imaging era. Patients and Methods Retrospective review at a single tertiary health care system (January 1, 1990, through December 31, 2015), evaluating 80 consecutive patients with sporadic FNS. Results Ninety-eight patients with FNS were identified; 10 with incomplete data and 8 with neurofibromatosis type 2 were excluded. The remaining 80 patients (median age, 47 years; 58% women) were analyzed. Forty-three (54%) patients presented with asymmetrical hearing loss, 33 (41%) reported facial paresis, and 21 (26%) reported facial spasm. Seventeen (21%) exhibited radiologic features mimicking vestibular schwannoma, 14 (18%) presented as a parotid mass, and 5 (6%) were discovered incidentally. Factors predictive of facial nerve paresis or spasm before treatment were female sex and tumor involvement of the labyrinthine/geniculate and tympanic facial nerve segments. The median growth rate among growing FNS was 2.0 mm/y. Details regarding clinical outcome according to treatment modality are described. Conclusion In patients with FNS, female sex and involvement of the labyrinthine/geniculate and tympanic segments of the facial nerve predict a higher probability of facial paresis or spasm. When isolated to the posterior fossa or parotid gland, establishing a preoperative diagnosis of FNS is challenging. Treatment should be tailored according to tumor location and size, existing facial nerve function, patient priorities, and age. A management algorithm is presented, prioritizing long-term facial nerve function. |
doi_str_mv | 10.1016/j.mayocp.2016.07.007 |
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Patients and Methods Retrospective review at a single tertiary health care system (January 1, 1990, through December 31, 2015), evaluating 80 consecutive patients with sporadic FNS. Results Ninety-eight patients with FNS were identified; 10 with incomplete data and 8 with neurofibromatosis type 2 were excluded. The remaining 80 patients (median age, 47 years; 58% women) were analyzed. Forty-three (54%) patients presented with asymmetrical hearing loss, 33 (41%) reported facial paresis, and 21 (26%) reported facial spasm. Seventeen (21%) exhibited radiologic features mimicking vestibular schwannoma, 14 (18%) presented as a parotid mass, and 5 (6%) were discovered incidentally. Factors predictive of facial nerve paresis or spasm before treatment were female sex and tumor involvement of the labyrinthine/geniculate and tympanic facial nerve segments. The median growth rate among growing FNS was 2.0 mm/y. Details regarding clinical outcome according to treatment modality are described. Conclusion In patients with FNS, female sex and involvement of the labyrinthine/geniculate and tympanic segments of the facial nerve predict a higher probability of facial paresis or spasm. When isolated to the posterior fossa or parotid gland, establishing a preoperative diagnosis of FNS is challenging. Treatment should be tailored according to tumor location and size, existing facial nerve function, patient priorities, and age. A management algorithm is presented, prioritizing long-term facial nerve function.</description><identifier>ISSN: 0025-6196</identifier><identifier>EISSN: 1942-5546</identifier><identifier>DOI: 10.1016/j.mayocp.2016.07.007</identifier><identifier>PMID: 27720200</identifier><identifier>CODEN: MACPAJ</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cranial Nerve Neoplasms - diagnosis ; Cranial Nerve Neoplasms - therapy ; Diagnosis, Differential ; Dizziness - etiology ; Facial Nerve Diseases - diagnosis ; Facial Nerve Diseases - therapy ; Facial Paralysis - etiology ; Female ; Headache - etiology ; Hearing Loss - etiology ; Hemifacial Spasm - etiology ; Humans ; Incidental Findings ; Internal Medicine ; Male ; Middle Aged ; Minnesota ; Neurilemmoma - diagnosis ; Neurilemmoma - therapy ; Paralysis ; Patient Outcome Assessment ; Retrospective Studies ; Schwann cells ; Tinnitus - etiology ; Young Adult</subject><ispartof>Mayo Clinic proceedings, 2016-11, Vol.91 (11), p.1563-1576</ispartof><rights>Mayo Foundation for Medical Education and Research</rights><rights>2016 Mayo Foundation for Medical Education and Research</rights><rights>Copyright © 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.</rights><rights>COPYRIGHT 2016 Frontline Medical Communications Inc.</rights><rights>Copyright Mayo Foundation for Medical Education and Research Nov 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-cc6771069ec2f798829fb3f3800622d5b69ca1c8f2695c8c58bdc613d4562a03</citedby><cites>FETCH-LOGICAL-c581t-cc6771069ec2f798829fb3f3800622d5b69ca1c8f2695c8c58bdc613d4562a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27720200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carlson, Matthew L., MD</creatorcontrib><creatorcontrib>Deep, Nicholas L., MD</creatorcontrib><creatorcontrib>Patel, Neil S., MD</creatorcontrib><creatorcontrib>Lundy, Larry B., MD</creatorcontrib><creatorcontrib>Tombers, Nicole M., RN</creatorcontrib><creatorcontrib>Lohse, Christine M., MS</creatorcontrib><creatorcontrib>Link, Michael J., MD</creatorcontrib><creatorcontrib>Driscoll, Colin L., MD</creatorcontrib><title>Facial Nerve Schwannomas: Review of 80 Cases Over 25 Years at Mayo Clinic</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>Abstract Objective To elucidate the long-term clinical behavior, treatment, and outcomes of sporadic facial nerve schwannoma (FNS) in a large cohort of patients managed in the post–magnetic resonance imaging era. Patients and Methods Retrospective review at a single tertiary health care system (January 1, 1990, through December 31, 2015), evaluating 80 consecutive patients with sporadic FNS. Results Ninety-eight patients with FNS were identified; 10 with incomplete data and 8 with neurofibromatosis type 2 were excluded. The remaining 80 patients (median age, 47 years; 58% women) were analyzed. Forty-three (54%) patients presented with asymmetrical hearing loss, 33 (41%) reported facial paresis, and 21 (26%) reported facial spasm. Seventeen (21%) exhibited radiologic features mimicking vestibular schwannoma, 14 (18%) presented as a parotid mass, and 5 (6%) were discovered incidentally. Factors predictive of facial nerve paresis or spasm before treatment were female sex and tumor involvement of the labyrinthine/geniculate and tympanic facial nerve segments. The median growth rate among growing FNS was 2.0 mm/y. Details regarding clinical outcome according to treatment modality are described. Conclusion In patients with FNS, female sex and involvement of the labyrinthine/geniculate and tympanic segments of the facial nerve predict a higher probability of facial paresis or spasm. When isolated to the posterior fossa or parotid gland, establishing a preoperative diagnosis of FNS is challenging. Treatment should be tailored according to tumor location and size, existing facial nerve function, patient priorities, and age. A management algorithm is presented, prioritizing long-term facial nerve function.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cranial Nerve Neoplasms - diagnosis</subject><subject>Cranial Nerve Neoplasms - therapy</subject><subject>Diagnosis, Differential</subject><subject>Dizziness - etiology</subject><subject>Facial Nerve Diseases - diagnosis</subject><subject>Facial Nerve Diseases - therapy</subject><subject>Facial Paralysis - etiology</subject><subject>Female</subject><subject>Headache - etiology</subject><subject>Hearing Loss - etiology</subject><subject>Hemifacial Spasm - etiology</subject><subject>Humans</subject><subject>Incidental Findings</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minnesota</subject><subject>Neurilemmoma - diagnosis</subject><subject>Neurilemmoma - therapy</subject><subject>Paralysis</subject><subject>Patient Outcome Assessment</subject><subject>Retrospective Studies</subject><subject>Schwann cells</subject><subject>Tinnitus - etiology</subject><subject>Young Adult</subject><issn>0025-6196</issn><issn>1942-5546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk9v1DAQxS0EotvCN0DIEhLikmA7tpNwQKpWFCoVKtFeOFneyYT1ksRbO7vVfvs6pPzrBflg2fq98fO8IeQFZzlnXL_d5L09eNjmIp1yVuaMlY_IgtdSZEpJ_ZgsGBMq07zWR-Q4xg1LRF3Lp-RIlKVggrEFOT-z4GxHv2DYI72C9a0dBt_b-I5-xb3DW-pbWjG6tBEjvdxjoELRb2hDpHakn5MFuuzc4OAZedLaLuLz-_2EXJ99uF5-yi4uP54vTy8yUBUfMwBdlpzpGkG0ZV1Vom5XRVtUjGkhGrXSNVgOVSt0raBKolUDmheNVFpYVpyQN3PZbfA3O4yj6V0E7Do7oN9Fw6tCyfTxSib01QN043dhSOYmquRKKzlR-Ux9tx0aN7R-DBbSarB34AdsXbo_laWQRbJeJMHrvwRrtN24jr7bjc4P8V9QziAEH2PA1myD6204GM7MlKHZmDlDM2VoWGlSQkn28t72btVj81v0K7QEvJ8BTG1OGQUTweEA2LiAMJrGu_-98LAA_IzQdj_wgPFPl0wUhpmraY6mMeK6YDLFVNwBua--dQ</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Carlson, Matthew L., MD</creator><creator>Deep, Nicholas L., MD</creator><creator>Patel, Neil S., MD</creator><creator>Lundy, Larry B., MD</creator><creator>Tombers, Nicole M., RN</creator><creator>Lohse, Christine M., MS</creator><creator>Link, Michael J., MD</creator><creator>Driscoll, Colin L., MD</creator><general>Elsevier Inc</general><general>Frontline Medical Communications Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Facial Nerve Schwannomas: Review of 80 Cases Over 25 Years at Mayo Clinic</title><author>Carlson, Matthew L., MD ; Deep, Nicholas L., MD ; Patel, Neil S., MD ; Lundy, Larry B., MD ; Tombers, Nicole M., RN ; Lohse, Christine M., MS ; Link, Michael J., MD ; Driscoll, Colin L., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-cc6771069ec2f798829fb3f3800622d5b69ca1c8f2695c8c58bdc613d4562a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cranial Nerve Neoplasms - diagnosis</topic><topic>Cranial Nerve Neoplasms - therapy</topic><topic>Diagnosis, Differential</topic><topic>Dizziness - etiology</topic><topic>Facial Nerve Diseases - diagnosis</topic><topic>Facial Nerve Diseases - therapy</topic><topic>Facial Paralysis - etiology</topic><topic>Female</topic><topic>Headache - etiology</topic><topic>Hearing Loss - etiology</topic><topic>Hemifacial Spasm - etiology</topic><topic>Humans</topic><topic>Incidental Findings</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Minnesota</topic><topic>Neurilemmoma - diagnosis</topic><topic>Neurilemmoma - therapy</topic><topic>Paralysis</topic><topic>Patient Outcome Assessment</topic><topic>Retrospective Studies</topic><topic>Schwann cells</topic><topic>Tinnitus - etiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carlson, Matthew L., MD</creatorcontrib><creatorcontrib>Deep, Nicholas L., MD</creatorcontrib><creatorcontrib>Patel, Neil S., MD</creatorcontrib><creatorcontrib>Lundy, Larry B., MD</creatorcontrib><creatorcontrib>Tombers, Nicole M., RN</creatorcontrib><creatorcontrib>Lohse, Christine M., MS</creatorcontrib><creatorcontrib>Link, Michael J., MD</creatorcontrib><creatorcontrib>Driscoll, Colin L., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Mayo Clinic proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carlson, Matthew L., MD</au><au>Deep, Nicholas L., MD</au><au>Patel, Neil S., MD</au><au>Lundy, Larry B., MD</au><au>Tombers, Nicole M., RN</au><au>Lohse, Christine M., MS</au><au>Link, Michael J., MD</au><au>Driscoll, Colin L., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Facial Nerve Schwannomas: Review of 80 Cases Over 25 Years at Mayo Clinic</atitle><jtitle>Mayo Clinic proceedings</jtitle><addtitle>Mayo Clin Proc</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>91</volume><issue>11</issue><spage>1563</spage><epage>1576</epage><pages>1563-1576</pages><issn>0025-6196</issn><eissn>1942-5546</eissn><coden>MACPAJ</coden><abstract>Abstract Objective To elucidate the long-term clinical behavior, treatment, and outcomes of sporadic facial nerve schwannoma (FNS) in a large cohort of patients managed in the post–magnetic resonance imaging era. Patients and Methods Retrospective review at a single tertiary health care system (January 1, 1990, through December 31, 2015), evaluating 80 consecutive patients with sporadic FNS. Results Ninety-eight patients with FNS were identified; 10 with incomplete data and 8 with neurofibromatosis type 2 were excluded. The remaining 80 patients (median age, 47 years; 58% women) were analyzed. Forty-three (54%) patients presented with asymmetrical hearing loss, 33 (41%) reported facial paresis, and 21 (26%) reported facial spasm. Seventeen (21%) exhibited radiologic features mimicking vestibular schwannoma, 14 (18%) presented as a parotid mass, and 5 (6%) were discovered incidentally. Factors predictive of facial nerve paresis or spasm before treatment were female sex and tumor involvement of the labyrinthine/geniculate and tympanic facial nerve segments. The median growth rate among growing FNS was 2.0 mm/y. Details regarding clinical outcome according to treatment modality are described. Conclusion In patients with FNS, female sex and involvement of the labyrinthine/geniculate and tympanic segments of the facial nerve predict a higher probability of facial paresis or spasm. When isolated to the posterior fossa or parotid gland, establishing a preoperative diagnosis of FNS is challenging. Treatment should be tailored according to tumor location and size, existing facial nerve function, patient priorities, and age. A management algorithm is presented, prioritizing long-term facial nerve function.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>27720200</pmid><doi>10.1016/j.mayocp.2016.07.007</doi><tpages>14</tpages></addata></record> |
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subjects | Adolescent Adult Aged Aged, 80 and over Cranial Nerve Neoplasms - diagnosis Cranial Nerve Neoplasms - therapy Diagnosis, Differential Dizziness - etiology Facial Nerve Diseases - diagnosis Facial Nerve Diseases - therapy Facial Paralysis - etiology Female Headache - etiology Hearing Loss - etiology Hemifacial Spasm - etiology Humans Incidental Findings Internal Medicine Male Middle Aged Minnesota Neurilemmoma - diagnosis Neurilemmoma - therapy Paralysis Patient Outcome Assessment Retrospective Studies Schwann cells Tinnitus - etiology Young Adult |
title | Facial Nerve Schwannomas: Review of 80 Cases Over 25 Years at Mayo Clinic |
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