Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites
We review approaches for determining metabolism of new synthetic cannabinoids (SCs), and challenges and advances in identifying optimal urinary marker metabolites of SC intake. Metabolic patterns of different SC generations are evaluated, and a practical strategy offered for selecting SC urinary mar...
Gespeichert in:
| Veröffentlicht in: | Clinical pharmacology and therapeutics 2017-02, Vol.101 (2), p.239-253 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 253 |
|---|---|
| container_issue | 2 |
| container_start_page | 239 |
| container_title | Clinical pharmacology and therapeutics |
| container_volume | 101 |
| creator | Diao, X Huestis, MA |
| description | We review approaches for determining metabolism of new synthetic cannabinoids (SCs), and challenges and advances in identifying optimal urinary marker metabolites of SC intake. Metabolic patterns of different SC generations are evaluated, and a practical strategy offered for selecting SC urinary marker metabolites. Novel SCs are incubated with human hepatocytes, the most abundant and characteristic metabolites are identified with high‐resolution mass spectrometry, and proposed hepatocyte marker metabolites are confirmed in authentic positive urine samples. |
| doi_str_mv | 10.1002/cpt.534 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1835398500</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1835398500</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3834-3b2273a10b72c928dd7ffa2f275623776da4e0dbbc2a6192a50b5b02f4f89e853</originalsourceid><addsrcrecordid>eNp1kN1O3DAQRi1EVba04g0q34HUhjp2HCeXq6g_SFAqFa6jsT3uGrJOsL2gfYS-dbNdyl2vZkY635HmI-SkZOclY_yTmfK5FNUBWZRS8KKWQh6SBWOsLVou6iPyJqW7-azapnlNjrhSXFVSLsjv5TTFEcwK00farWAYMPza7RAsXdpHCAYT9YFeYQY9Dj6t6ejod3yiP7chrzB7QzsIAbQPo7fpb_DCYsjeeQPZj2EXuJ6yX8NAb6MPELf0CuI9xhdrxvSWvHIwJHz3PI_J7ZfPN9234vL660W3vCyMaERVCM25ElAyrbhpeWOtcg6440rWXChVW6iQWa0Nh7psOUimpWbcVa5psZHimJztvfPfDxtMuV_7ZHAYIOC4SX3ZCCnaRjI2o6d71MQxpYiun-L8Rdz2Jet3vfdz7_3c-0y-f5Zu9BrtC_ev6Bn4sAee_IDb_3n67sfNTvcHEPuM_A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1835398500</pqid></control><display><type>article</type><title>Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Diao, X ; Huestis, MA</creator><creatorcontrib>Diao, X ; Huestis, MA</creatorcontrib><description>We review approaches for determining metabolism of new synthetic cannabinoids (SCs), and challenges and advances in identifying optimal urinary marker metabolites of SC intake. Metabolic patterns of different SC generations are evaluated, and a practical strategy offered for selecting SC urinary marker metabolites. Novel SCs are incubated with human hepatocytes, the most abundant and characteristic metabolites are identified with high‐resolution mass spectrometry, and proposed hepatocyte marker metabolites are confirmed in authentic positive urine samples.</description><identifier>ISSN: 0009-9236</identifier><identifier>EISSN: 1532-6535</identifier><identifier>DOI: 10.1002/cpt.534</identifier><identifier>PMID: 27727455</identifier><language>eng</language><publisher>United States</publisher><subject>Biomarkers ; Blood Chemical Analysis ; Cannabinoids - adverse effects ; Cannabinoids - analysis ; Cannabinoids - chemistry ; Cannabinoids - pharmacokinetics ; Chromatography, Liquid ; Computer Simulation ; Designer Drugs - adverse effects ; Designer Drugs - analysis ; Designer Drugs - chemistry ; Designer Drugs - pharmacokinetics ; Hepatocytes - chemistry ; Humans ; Marijuana Abuse - epidemiology ; Marijuana Abuse - urine ; Microsomes, Liver - chemistry ; Structure-Activity Relationship ; Substance Abuse Detection - methods ; Tandem Mass Spectrometry ; Urinalysis</subject><ispartof>Clinical pharmacology and therapeutics, 2017-02, Vol.101 (2), p.239-253</ispartof><rights>Published 2016. This article is a U.S. Government work and is in the public domain in the USA.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3834-3b2273a10b72c928dd7ffa2f275623776da4e0dbbc2a6192a50b5b02f4f89e853</citedby><cites>FETCH-LOGICAL-c3834-3b2273a10b72c928dd7ffa2f275623776da4e0dbbc2a6192a50b5b02f4f89e853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcpt.534$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcpt.534$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27727455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diao, X</creatorcontrib><creatorcontrib>Huestis, MA</creatorcontrib><title>Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites</title><title>Clinical pharmacology and therapeutics</title><addtitle>Clin Pharmacol Ther</addtitle><description>We review approaches for determining metabolism of new synthetic cannabinoids (SCs), and challenges and advances in identifying optimal urinary marker metabolites of SC intake. Metabolic patterns of different SC generations are evaluated, and a practical strategy offered for selecting SC urinary marker metabolites. Novel SCs are incubated with human hepatocytes, the most abundant and characteristic metabolites are identified with high‐resolution mass spectrometry, and proposed hepatocyte marker metabolites are confirmed in authentic positive urine samples.</description><subject>Biomarkers</subject><subject>Blood Chemical Analysis</subject><subject>Cannabinoids - adverse effects</subject><subject>Cannabinoids - analysis</subject><subject>Cannabinoids - chemistry</subject><subject>Cannabinoids - pharmacokinetics</subject><subject>Chromatography, Liquid</subject><subject>Computer Simulation</subject><subject>Designer Drugs - adverse effects</subject><subject>Designer Drugs - analysis</subject><subject>Designer Drugs - chemistry</subject><subject>Designer Drugs - pharmacokinetics</subject><subject>Hepatocytes - chemistry</subject><subject>Humans</subject><subject>Marijuana Abuse - epidemiology</subject><subject>Marijuana Abuse - urine</subject><subject>Microsomes, Liver - chemistry</subject><subject>Structure-Activity Relationship</subject><subject>Substance Abuse Detection - methods</subject><subject>Tandem Mass Spectrometry</subject><subject>Urinalysis</subject><issn>0009-9236</issn><issn>1532-6535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kN1O3DAQRi1EVba04g0q34HUhjp2HCeXq6g_SFAqFa6jsT3uGrJOsL2gfYS-dbNdyl2vZkY635HmI-SkZOclY_yTmfK5FNUBWZRS8KKWQh6SBWOsLVou6iPyJqW7-azapnlNjrhSXFVSLsjv5TTFEcwK00farWAYMPza7RAsXdpHCAYT9YFeYQY9Dj6t6ejod3yiP7chrzB7QzsIAbQPo7fpb_DCYsjeeQPZj2EXuJ6yX8NAb6MPELf0CuI9xhdrxvSWvHIwJHz3PI_J7ZfPN9234vL660W3vCyMaERVCM25ElAyrbhpeWOtcg6440rWXChVW6iQWa0Nh7psOUimpWbcVa5psZHimJztvfPfDxtMuV_7ZHAYIOC4SX3ZCCnaRjI2o6d71MQxpYiun-L8Rdz2Jet3vfdz7_3c-0y-f5Zu9BrtC_ev6Bn4sAee_IDb_3n67sfNTvcHEPuM_A</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Diao, X</creator><creator>Huestis, MA</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201702</creationdate><title>Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites</title><author>Diao, X ; Huestis, MA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3834-3b2273a10b72c928dd7ffa2f275623776da4e0dbbc2a6192a50b5b02f4f89e853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Biomarkers</topic><topic>Blood Chemical Analysis</topic><topic>Cannabinoids - adverse effects</topic><topic>Cannabinoids - analysis</topic><topic>Cannabinoids - chemistry</topic><topic>Cannabinoids - pharmacokinetics</topic><topic>Chromatography, Liquid</topic><topic>Computer Simulation</topic><topic>Designer Drugs - adverse effects</topic><topic>Designer Drugs - analysis</topic><topic>Designer Drugs - chemistry</topic><topic>Designer Drugs - pharmacokinetics</topic><topic>Hepatocytes - chemistry</topic><topic>Humans</topic><topic>Marijuana Abuse - epidemiology</topic><topic>Marijuana Abuse - urine</topic><topic>Microsomes, Liver - chemistry</topic><topic>Structure-Activity Relationship</topic><topic>Substance Abuse Detection - methods</topic><topic>Tandem Mass Spectrometry</topic><topic>Urinalysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diao, X</creatorcontrib><creatorcontrib>Huestis, MA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diao, X</au><au>Huestis, MA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites</atitle><jtitle>Clinical pharmacology and therapeutics</jtitle><addtitle>Clin Pharmacol Ther</addtitle><date>2017-02</date><risdate>2017</risdate><volume>101</volume><issue>2</issue><spage>239</spage><epage>253</epage><pages>239-253</pages><issn>0009-9236</issn><eissn>1532-6535</eissn><abstract>We review approaches for determining metabolism of new synthetic cannabinoids (SCs), and challenges and advances in identifying optimal urinary marker metabolites of SC intake. Metabolic patterns of different SC generations are evaluated, and a practical strategy offered for selecting SC urinary marker metabolites. Novel SCs are incubated with human hepatocytes, the most abundant and characteristic metabolites are identified with high‐resolution mass spectrometry, and proposed hepatocyte marker metabolites are confirmed in authentic positive urine samples.</abstract><cop>United States</cop><pmid>27727455</pmid><doi>10.1002/cpt.534</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9236 |
| ispartof | Clinical pharmacology and therapeutics, 2017-02, Vol.101 (2), p.239-253 |
| issn | 0009-9236 1532-6535 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1835398500 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Biomarkers Blood Chemical Analysis Cannabinoids - adverse effects Cannabinoids - analysis Cannabinoids - chemistry Cannabinoids - pharmacokinetics Chromatography, Liquid Computer Simulation Designer Drugs - adverse effects Designer Drugs - analysis Designer Drugs - chemistry Designer Drugs - pharmacokinetics Hepatocytes - chemistry Humans Marijuana Abuse - epidemiology Marijuana Abuse - urine Microsomes, Liver - chemistry Structure-Activity Relationship Substance Abuse Detection - methods Tandem Mass Spectrometry Urinalysis |
| title | Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T04%3A13%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Approaches,%20Challenges,%20and%20Advances%20in%20Metabolism%20of%20New%20Synthetic%20Cannabinoids%20and%20Identification%20of%20Optimal%20Urinary%20Marker%20Metabolites&rft.jtitle=Clinical%20pharmacology%20and%20therapeutics&rft.au=Diao,%20X&rft.date=2017-02&rft.volume=101&rft.issue=2&rft.spage=239&rft.epage=253&rft.pages=239-253&rft.issn=0009-9236&rft.eissn=1532-6535&rft_id=info:doi/10.1002/cpt.534&rft_dat=%3Cproquest_cross%3E1835398500%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1835398500&rft_id=info:pmid/27727455&rfr_iscdi=true |