Are Charge-State Distributions a Reliable Tool Describing Molecular Ensembles of Intrinsically Disordered Proteins by Native MS?

Native mass spectrometry (MS) has become a central tool of structural proteomics, but its applicability to the peculiar class of intrinsically disordered proteins (IDPs) is still object of debate. IDPs lack an ordered tridimensional structure and are characterized by high conformational plasticity....

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Veröffentlicht in:	Journal of the American Society for Mass Spectrometry 2017, Vol.28 (1), p.21-28
Hauptverfasser:	Natalello, Antonino, Santambrogio, Carlo, Grandori, Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Animals Bioinformatics Biotechnology Charge distribution Chemistry Chemistry and Materials Science Cyclin-Dependent Kinase Inhibitor Proteins - chemistry Electrospraying Focus: 31st Asilomar Conference Humans Intrinsically Disordered Proteins - chemistry Ionic mobility Ionization Ions Mass spectrometry Models, Molecular Native MS-based Structural Biology: Account & Perspective Organic Chemistry Protein Conformation Protein Multimerization Proteins Proteomics Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae Proteins - chemistry Spectrometry, Mass, Electrospray Ionization - methods Static Electricity Tumor Suppressor Protein p53 - chemistry
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