Catalytic Asymmetric Synthesis of Morpholines. Using Mechanistic Insights To Realize the Enantioselective Synthesis of Piperazines

An efficient and practical catalytic approach for the enantioselective synthesis of 3-substituted morpholines through a tandem sequential one-pot reaction employing both hydroamination and asymmetric transfer hydrogenation reactions is described. Starting from ether-containing aminoalkyne substrates...

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Veröffentlicht in:	Journal of organic chemistry 2016-10, Vol.81 (19), p.8696-8709
Hauptverfasser:	Lau, Ying Yin, Zhai, Huimin, Schafer, Laurel L
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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