Therapeutic efficacy of an anti-PD-L1 antibody based immunocytokine in a metastatic mouse model of colorectal cancer

Immunocytokines (antibody-cytokine fusions) have been proved to be a promising class of therapeutic agents for tumors. Anti-PD-L1 antibodies or IL-2 have been used to treat a variety of cancers. Here, in order to remove T cell inhibition and increasing the IL-2 concentration in the tumor microenviro...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-11, Vol.480 (2), p.160-165
Hauptverfasser:	Chen, Xi, Xu, Jin, Guo, Qingcheng, Wang, Lingfei, Yang, Yun, Guo, Huaizu, Gu, Nana, Zhang, Dapeng, Qian, Weizhu, Hou, Sheng, Li, Jing, Dai, Jianxin, Guo, Yajun, Wang, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-PD-L1 Antibodies, Monoclonal - genetics Antibodies, Monoclonal - pharmacology Antineoplastic Agents - immunology Antineoplastic Agents - pharmacology B7-H1 Antigen - immunology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - secretion CHO Cells Colorectal Neoplasms - drug therapy Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Cricetulus Female Humans IL-2 Immunocytokine Interferon-gamma - secretion Interleukin-2 - genetics Interleukin-2 - immunology Metastatic colorectal cancer Mice, Inbred BALB C Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - pharmacology T cell activation Tumor inhibition Xenograft Model Antitumor Assays
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