BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

[Display omitted] The pro-inflammatory leukotrienes (LTs) are formed from arachidonic acid (AA) in activated leukocytes, where 5-lipoxygenase (5-LO) translocates to the nuclear envelope to assemble a functional complex with the integral nuclear membrane protein 5-LO-activating protein (FLAP). FLAP,...

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Veröffentlicht in:	Biochemical pharmacology 2016-11, Vol.119, p.17-26
Hauptverfasser:	Garscha, Ulrike, Voelker, Susanna, Pace, Simona, Gerstmeier, Jana, Emini, Besa, Liening, Stefanie, Rossi, Antonietta, Weinigel, Christina, Rummler, Silke, Schubert, Ulrich S., Scriba, Gerhard K.E., Çelikoğlu, Erşan, Çalışkan, Burcu, Banoglu, Erden, Sautebin, Lidia, Werz, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Lipoxygenase 5-Lipoxygenase-activating protein 5-Lipoxygenase-Activating Proteins - genetics 5-Lipoxygenase-Activating Proteins - metabolism Animals Arachidonate 5-Lipoxygenase - genetics Arachidonate 5-Lipoxygenase - metabolism Arachidonic acid Cell-Free System Gene Expression Regulation, Enzymologic - drug effects HEK293 Cells Humans Hydroxyurea - analogs & derivatives Hydroxyurea - pharmacology Indoles - pharmacology Inflammation Isoxazoles - chemistry Isoxazoles - metabolism Isoxazoles - pharmacology Leukotriene Leukotriene Antagonists - chemistry Leukotriene Antagonists - metabolism Leukotriene Antagonists - pharmacology Leukotrienes - biosynthesis Male Mice Molecular Structure Peritonitis - chemically induced Peritonitis - drug therapy Quinolines - chemistry Quinolines - metabolism Quinolines - pharmacology Zymosan - toxicity
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