Positive affect and regional cerebral blood flow in Alzheimer's disease
Abstract Quality of life (QOL) has been recently recognized as the central purpose of healthcare, and positive affect is one of the core dimension of QOL. However, positive affect among patients with dementia or Alzheimer's disease (AD) has not received much attention in the medical research fi...
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| Veröffentlicht in: | Psychiatry research. Neuroimaging 2016-10, Vol.256, p.15-20 |
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| creator | Hayashi, Satoshi Terada, Seishi Sato, Shuhei Oshima, Etsuko Miki, Tomoko Yokota, Osamu Ishihara, Takeshi Yamada, Norihito |
| description | Abstract Quality of life (QOL) has been recently recognized as the central purpose of healthcare, and positive affect is one of the core dimension of QOL. However, positive affect among patients with dementia or Alzheimer's disease (AD) has not received much attention in the medical research field. One hundred sixteen consecutive patients with AD were recruited from the outpatient units of the Memory Clinic of Okayama University Hospital. The positive affect score was evaluated using the positive affect domain of the Quality of Life questionnaire for Dementia (QOL-D). Patients underwent brain SPECT with 99mTc-ethylcysteinate dimer. Positive affect scores were inversely related to apathy scores, subjective depressive scores, and delusion scores. After removing the effects of age, sex, duration of education, and cognitive function, positive affect scores showed a significant correlation with regional cerebral blood flow in the left premotor and superior frontal gyri. The left premotor and superior frontal area is significantly involved in the pathogenesis of the decrease of positive affect in AD. Apathy and depression are closely related to the prefrontal area in AD, and they may affect the relationship between positive affect and the left prefrontal area. |
| doi_str_mv | 10.1016/j.pscychresns.2016.09.003 |
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However, positive affect among patients with dementia or Alzheimer's disease (AD) has not received much attention in the medical research field. One hundred sixteen consecutive patients with AD were recruited from the outpatient units of the Memory Clinic of Okayama University Hospital. The positive affect score was evaluated using the positive affect domain of the Quality of Life questionnaire for Dementia (QOL-D). Patients underwent brain SPECT with 99mTc-ethylcysteinate dimer. Positive affect scores were inversely related to apathy scores, subjective depressive scores, and delusion scores. After removing the effects of age, sex, duration of education, and cognitive function, positive affect scores showed a significant correlation with regional cerebral blood flow in the left premotor and superior frontal gyri. The left premotor and superior frontal area is significantly involved in the pathogenesis of the decrease of positive affect in AD. Apathy and depression are closely related to the prefrontal area in AD, and they may affect the relationship between positive affect and the left prefrontal area.</description><identifier>ISSN: 0925-4927</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2016.09.003</identifier><identifier>PMID: 27640073</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Affect - physiology ; Aged ; Aged, 80 and over ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - physiopathology ; Alzheimer Disease - psychology ; Alzheimer's disease (AD) ; Apathy - physiology ; Brain - diagnostic imaging ; Brain - physiopathology ; Cerebrovascular Circulation - physiology ; Cysteine - analogs & derivatives ; Depression - diagnostic imaging ; Depression - physiopathology ; Depression - psychology ; Female ; Frontal Lobe - diagnostic imaging ; Frontal Lobe - physiopathology ; Humans ; Male ; Middle Aged ; Organotechnetium Compounds ; Positive affect ; Psychiatry ; Quality of Life - psychology ; Quality of Life questionnaire for Dementia (QOL-D) ; Radiology ; Regional cerebral blood flow (rCBF) ; Severity of Illness Index ; Surveys and Questionnaires ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Psychiatry research. Neuroimaging, 2016-10, Vol.256, p.15-20</ispartof><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-f847b014a47fd03880147705d6b9d80cf12e38cd50dafe1bc4c1c6cbefb224b93</citedby><cites>FETCH-LOGICAL-c498t-f847b014a47fd03880147705d6b9d80cf12e38cd50dafe1bc4c1c6cbefb224b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pscychresns.2016.09.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27640073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayashi, Satoshi</creatorcontrib><creatorcontrib>Terada, Seishi</creatorcontrib><creatorcontrib>Sato, Shuhei</creatorcontrib><creatorcontrib>Oshima, Etsuko</creatorcontrib><creatorcontrib>Miki, Tomoko</creatorcontrib><creatorcontrib>Yokota, Osamu</creatorcontrib><creatorcontrib>Ishihara, Takeshi</creatorcontrib><creatorcontrib>Yamada, Norihito</creatorcontrib><title>Positive affect and regional cerebral blood flow in Alzheimer's disease</title><title>Psychiatry research. Neuroimaging</title><addtitle>Psychiatry Res Neuroimaging</addtitle><description>Abstract Quality of life (QOL) has been recently recognized as the central purpose of healthcare, and positive affect is one of the core dimension of QOL. However, positive affect among patients with dementia or Alzheimer's disease (AD) has not received much attention in the medical research field. One hundred sixteen consecutive patients with AD were recruited from the outpatient units of the Memory Clinic of Okayama University Hospital. The positive affect score was evaluated using the positive affect domain of the Quality of Life questionnaire for Dementia (QOL-D). Patients underwent brain SPECT with 99mTc-ethylcysteinate dimer. Positive affect scores were inversely related to apathy scores, subjective depressive scores, and delusion scores. After removing the effects of age, sex, duration of education, and cognitive function, positive affect scores showed a significant correlation with regional cerebral blood flow in the left premotor and superior frontal gyri. The left premotor and superior frontal area is significantly involved in the pathogenesis of the decrease of positive affect in AD. Apathy and depression are closely related to the prefrontal area in AD, and they may affect the relationship between positive affect and the left prefrontal area.</description><subject>Affect - physiology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease (AD)</subject><subject>Apathy - physiology</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiopathology</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cysteine - analogs & derivatives</subject><subject>Depression - diagnostic imaging</subject><subject>Depression - physiopathology</subject><subject>Depression - psychology</subject><subject>Female</subject><subject>Frontal Lobe - diagnostic imaging</subject><subject>Frontal Lobe - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organotechnetium Compounds</subject><subject>Positive affect</subject><subject>Psychiatry</subject><subject>Quality of Life - psychology</subject><subject>Quality of Life questionnaire for Dementia (QOL-D)</subject><subject>Radiology</subject><subject>Regional cerebral blood flow (rCBF)</subject><subject>Severity of Illness Index</subject><subject>Surveys and Questionnaires</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0925-4927</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9vEzEQxS1ERUPhK6DlBJfdju3d9fqCVEWlRapUJOBs-c-YOjjrYCdF6afHUVqEOHGa0ejNjN7vEfKWQkeBjuerblPs3t5lLHPpWB11IDsA_ows6CRYKwYYn5MFSDa0vWTilLwsZQXA-DTyF-SUibEHEHxBrj6nErbhHhvtPdpto2fXZPwe0qxjYzGjybUxMSXX-Jh-NWFuLuLDHYY15nelcaGgLviKnHgdC75-rGfk28fLr8vr9ub26tPy4qa1vZy2rZ96YYD2uhfeAZ-m2gsBgxuNdBNYTxnyyboBnPZIje0ttaM16A1jvZH8jLw_3t3k9HOHZavWoViMUc-YdkXRiQ9cUt5Dlcqj1OZUSkavNjmsdd4rCurAUa3UXxzVgaMCqSrHuvvm8c3OrNH92XwCVwXLowCr2fuAWRUbcLboQq4YlUvhv958-OeKjWEOVscfuMeySrtcY6iuVGEK1JdDoIc86ciBMjHw33qQn3k</recordid><startdate>20161030</startdate><enddate>20161030</enddate><creator>Hayashi, Satoshi</creator><creator>Terada, Seishi</creator><creator>Sato, Shuhei</creator><creator>Oshima, Etsuko</creator><creator>Miki, Tomoko</creator><creator>Yokota, Osamu</creator><creator>Ishihara, Takeshi</creator><creator>Yamada, Norihito</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161030</creationdate><title>Positive affect and regional cerebral blood flow in Alzheimer's disease</title><author>Hayashi, Satoshi ; 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| subjects | Affect - physiology Aged Aged, 80 and over Alzheimer Disease - diagnostic imaging Alzheimer Disease - physiopathology Alzheimer Disease - psychology Alzheimer's disease (AD) Apathy - physiology Brain - diagnostic imaging Brain - physiopathology Cerebrovascular Circulation - physiology Cysteine - analogs & derivatives Depression - diagnostic imaging Depression - physiopathology Depression - psychology Female Frontal Lobe - diagnostic imaging Frontal Lobe - physiopathology Humans Male Middle Aged Organotechnetium Compounds Positive affect Psychiatry Quality of Life - psychology Quality of Life questionnaire for Dementia (QOL-D) Radiology Regional cerebral blood flow (rCBF) Severity of Illness Index Surveys and Questionnaires Tomography, Emission-Computed, Single-Photon |
| title | Positive affect and regional cerebral blood flow in Alzheimer's disease |
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