Retrospective evaluation of blood copper stable isotopes ratio 65 Cu/ 63 Cu as a biomarker of cancer in dogs
Previous studies in humans with breast, colorectal or liver cancer showed that neoplasia was associated with a modification of the blood ratio between Cu and Cu (∂Cu). The aim of the present study was to compare the blood ∂Cu of dogs with cancer to healthy controls or dogs with non-oncologic disease...
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| Veröffentlicht in: | Veterinary & comparative oncology 2017-12, Vol.15 (4), p.1323-1332 |
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| container_title | Veterinary & comparative oncology |
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| creator | Chamel, G Gourlan, A T Télouk, P Sayag, D Milliard, V Loiseau, C Simon, M Buff, S Ponce, F |
| description | Previous studies in humans with breast, colorectal or liver cancer showed that neoplasia was associated with a modification of the blood ratio between
Cu and
Cu (∂Cu). The aim of the present study was to compare the blood ∂Cu of dogs with cancer to healthy controls or dogs with non-oncologic disease. One hundred and seventeen dogs were included in the study (35 dogs with cancer, 33 dogs with non-neoplastic disease, and 49 healthy controls). The ∂Cu of dogs with cancer was significantly lower than the ratio of healthy controls (P |
| doi_str_mv | 10.1111/vco.12273 |
| format | Article |
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Cu and
Cu (∂Cu). The aim of the present study was to compare the blood ∂Cu of dogs with cancer to healthy controls or dogs with non-oncologic disease. One hundred and seventeen dogs were included in the study (35 dogs with cancer, 33 dogs with non-neoplastic disease, and 49 healthy controls). The ∂Cu of dogs with cancer was significantly lower than the ratio of healthy controls (P < 0.0001) but not significantly different from dogs with non-oncologic disease. Six dogs with lymphoma were also evaluated after they achieved clinical remission and five out of six had an increase of ∂Cu. Further studies are warranted but these results suggest that ∂Cu could help in the diagnosis of cancer in a controlled clinical context, and may be a potential biomarker for the follow-up of cancer.</description><identifier>ISSN: 1476-5810</identifier><identifier>EISSN: 1476-5829</identifier><identifier>DOI: 10.1111/vco.12273</identifier><identifier>PMID: 27714906</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Biomarkers, Tumor - blood ; Copper - blood ; Copper Radioisotopes - blood ; Dog Diseases - blood ; Dog Diseases - diagnosis ; Dogs ; Female ; Male ; Mass Spectrometry - veterinary ; Neoplasms - blood ; Neoplasms - diagnosis ; Neoplasms - veterinary ; Retrospective Studies</subject><ispartof>Veterinary & comparative oncology, 2017-12, Vol.15 (4), p.1323-1332</ispartof><rights>2016 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1306-a1dacae1307ec5774ea3de9aeda056b099be8cdda2fe5b6ec06a988063870fd03</citedby><cites>FETCH-LOGICAL-c1306-a1dacae1307ec5774ea3de9aeda056b099be8cdda2fe5b6ec06a988063870fd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27714906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chamel, G</creatorcontrib><creatorcontrib>Gourlan, A T</creatorcontrib><creatorcontrib>Télouk, P</creatorcontrib><creatorcontrib>Sayag, D</creatorcontrib><creatorcontrib>Milliard, V</creatorcontrib><creatorcontrib>Loiseau, C</creatorcontrib><creatorcontrib>Simon, M</creatorcontrib><creatorcontrib>Buff, S</creatorcontrib><creatorcontrib>Ponce, F</creatorcontrib><title>Retrospective evaluation of blood copper stable isotopes ratio 65 Cu/ 63 Cu as a biomarker of cancer in dogs</title><title>Veterinary & comparative oncology</title><addtitle>Vet Comp Oncol</addtitle><description>Previous studies in humans with breast, colorectal or liver cancer showed that neoplasia was associated with a modification of the blood ratio between
Cu and
Cu (∂Cu). The aim of the present study was to compare the blood ∂Cu of dogs with cancer to healthy controls or dogs with non-oncologic disease. One hundred and seventeen dogs were included in the study (35 dogs with cancer, 33 dogs with non-neoplastic disease, and 49 healthy controls). The ∂Cu of dogs with cancer was significantly lower than the ratio of healthy controls (P < 0.0001) but not significantly different from dogs with non-oncologic disease. Six dogs with lymphoma were also evaluated after they achieved clinical remission and five out of six had an increase of ∂Cu. Further studies are warranted but these results suggest that ∂Cu could help in the diagnosis of cancer in a controlled clinical context, and may be a potential biomarker for the follow-up of cancer.</description><subject>Animals</subject><subject>Biomarkers, Tumor - blood</subject><subject>Copper - blood</subject><subject>Copper Radioisotopes - blood</subject><subject>Dog Diseases - blood</subject><subject>Dog Diseases - diagnosis</subject><subject>Dogs</subject><subject>Female</subject><subject>Male</subject><subject>Mass Spectrometry - veterinary</subject><subject>Neoplasms - blood</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - veterinary</subject><subject>Retrospective Studies</subject><issn>1476-5810</issn><issn>1476-5829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EoqWw4AeQl7BI60diJ0tUlYdUCQnBOprYExRw4xAnlfh7XFo6m7mLM1ejQ8g1Z3MeZ7E1fs6F0PKETHmqVZLlojg9Zs4m5CKET8aESKU4JxOhNU8LpqbEveLQ-9ChGZotUtyCG2FofEt9TSvnvaXGdx32NAxQOaRN8IPvMNB-h1GV0eW4oErGRSFQoFXjN9B_xYvYYKA1MTUttf4jXJKzGlzAq8OekfeH1dvyKVm_PD4v79eJ4ZKpBLgFAxizRpNpnSJIiwWgBZapihVFhbmxFkSNWaXQMAVFnjMlc81qy-SM3O57u95_jxiGctMEg85Bi34MJc9lJgvOxA6926MmWgg91mXXN_H_n5Kzcie3jHLLP7mRvTnUjtUG7ZH8tyl_AZOBdSU</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Chamel, G</creator><creator>Gourlan, A T</creator><creator>Télouk, P</creator><creator>Sayag, D</creator><creator>Milliard, V</creator><creator>Loiseau, C</creator><creator>Simon, M</creator><creator>Buff, S</creator><creator>Ponce, F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201712</creationdate><title>Retrospective evaluation of blood copper stable isotopes ratio 65 Cu/ 63 Cu as a biomarker of cancer in dogs</title><author>Chamel, G ; Gourlan, A T ; Télouk, P ; Sayag, D ; Milliard, V ; Loiseau, C ; Simon, M ; Buff, S ; Ponce, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1306-a1dacae1307ec5774ea3de9aeda056b099be8cdda2fe5b6ec06a988063870fd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Biomarkers, Tumor - blood</topic><topic>Copper - blood</topic><topic>Copper Radioisotopes - blood</topic><topic>Dog Diseases - blood</topic><topic>Dog Diseases - diagnosis</topic><topic>Dogs</topic><topic>Female</topic><topic>Male</topic><topic>Mass Spectrometry - veterinary</topic><topic>Neoplasms - blood</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - veterinary</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chamel, G</creatorcontrib><creatorcontrib>Gourlan, A T</creatorcontrib><creatorcontrib>Télouk, P</creatorcontrib><creatorcontrib>Sayag, D</creatorcontrib><creatorcontrib>Milliard, V</creatorcontrib><creatorcontrib>Loiseau, C</creatorcontrib><creatorcontrib>Simon, M</creatorcontrib><creatorcontrib>Buff, S</creatorcontrib><creatorcontrib>Ponce, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary & comparative oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chamel, G</au><au>Gourlan, A T</au><au>Télouk, P</au><au>Sayag, D</au><au>Milliard, V</au><au>Loiseau, C</au><au>Simon, M</au><au>Buff, S</au><au>Ponce, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrospective evaluation of blood copper stable isotopes ratio 65 Cu/ 63 Cu as a biomarker of cancer in dogs</atitle><jtitle>Veterinary & comparative oncology</jtitle><addtitle>Vet Comp Oncol</addtitle><date>2017-12</date><risdate>2017</risdate><volume>15</volume><issue>4</issue><spage>1323</spage><epage>1332</epage><pages>1323-1332</pages><issn>1476-5810</issn><eissn>1476-5829</eissn><abstract>Previous studies in humans with breast, colorectal or liver cancer showed that neoplasia was associated with a modification of the blood ratio between
Cu and
Cu (∂Cu). The aim of the present study was to compare the blood ∂Cu of dogs with cancer to healthy controls or dogs with non-oncologic disease. One hundred and seventeen dogs were included in the study (35 dogs with cancer, 33 dogs with non-neoplastic disease, and 49 healthy controls). The ∂Cu of dogs with cancer was significantly lower than the ratio of healthy controls (P < 0.0001) but not significantly different from dogs with non-oncologic disease. Six dogs with lymphoma were also evaluated after they achieved clinical remission and five out of six had an increase of ∂Cu. Further studies are warranted but these results suggest that ∂Cu could help in the diagnosis of cancer in a controlled clinical context, and may be a potential biomarker for the follow-up of cancer.</abstract><cop>England</cop><pmid>27714906</pmid><doi>10.1111/vco.12273</doi><tpages>10</tpages></addata></record> |
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| ispartof | Veterinary & comparative oncology, 2017-12, Vol.15 (4), p.1323-1332 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biomarkers, Tumor - blood Copper - blood Copper Radioisotopes - blood Dog Diseases - blood Dog Diseases - diagnosis Dogs Female Male Mass Spectrometry - veterinary Neoplasms - blood Neoplasms - diagnosis Neoplasms - veterinary Retrospective Studies |
| title | Retrospective evaluation of blood copper stable isotopes ratio 65 Cu/ 63 Cu as a biomarker of cancer in dogs |
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