Phage-display screening identifies LMP1-binding peptides targeting the C-terminus region of the EBV oncoprotein

•C-terminus LMP1 region was produced in E. coli as recombinant protein.•A phage display library was screened with the recombinant protein as target.•Two peptides (FO5,and NO4) recognize specifically the CTAR of LMP1.•NO4, FO5 are potential candidates able to modulate the activity of LMP1. Latent mem...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2016-11, Vol.85, p.73-79
Hauptverfasser:	Ammous-Boukhris, Nihel, Mosbah, Amor, Sahli, Emna, Ayadi, Wajdi, Hadhri-Guiga, Boutheina, Chérif, Ameur, Gargouri, Ali, Mokdad-Gargouri, Raja
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects B-lymphocytes B-Lymphocytes - drug effects B-Lymphocytes - metabolism B-Lymphocytes - pathology bacteriophages binding capacity clones death domain receptors DNA libraries Escherichia coli Gene Expression Regulation, Viral Herpesvirus 4, Human - drug effects Herpesvirus 4, Human - pathogenicity Human gammaherpesvirus 4 Humans immunity LMP1 Molecular docking Molecular Docking Simulation molecular models necrosis Neoplasms - drug therapy Neoplasms - genetics Neoplasms - virology oncogene proteins Oncogene Proteins - chemistry Oncogene Proteins - genetics Oncogene Proteins - metabolism Oncoprotein Peptide peptide libraries Peptide Library Peptides - isolation & purification Peptides - metabolism Peptides - pharmacology Phage display Protein Binding screening sequence alignment sequence homology tissues Viral Matrix Proteins - chemistry Viral Matrix Proteins - genetics Viral Matrix Proteins - metabolism
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