Microparticle surface layering through dry coating: impact of moisture content and process parameters on the properties of orally disintegrating tablets

Objectives The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs). Methods Th...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2017-07, Vol.69 (7), p.807-822
Hauptverfasser:	Alyami, Hamad, Koner, Jasdip, Dahmash, Eman Z., Bowen, James, Terry, David, Mohammed, Afzal R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Atomic force microscopy Cellulose Cellulose - chemistry Chemistry, Pharmaceutical - methods Coating composite Control surfaces Crystalline cellulose disintegration Drug Compounding - methods Drying Electron microscopy Excipients Excipients - chemistry flowability Hardness Microscopy Microscopy, Atomic Force - methods Microscopy, Electron, Scanning Moisture content nano‐indentation Powder Powder coating Powders Scanning electron microscopy Studies Tablets Temporal variations Thermogravimetric analysis Thermogravimetry - methods
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