Evaluation of the Effects of S-Allyl-L-cysteine, S-Methyl-L-cysteine, trans-S-1-Propenyl-L-cysteine, and Their N-Acetylated and S-Oxidized Metabolites on Human CYP Activities

Three major organosulfur compounds of aged garlic extract, S-allyl-L-cysteine (SAC), S-methyl-L-cysteine (SMC), and trans-S-1-propenyl-L-cysteine (S1PC), were examined for their effects on the activities of five major isoforms of human CYP enzymes: CYP1A2, 2C9, 2C19, 2D6, and 3A4. The metabolite for...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2016/10/01, Vol.39(10), pp.1701-1707
Hauptverfasser:	Amano, Hirotaka, Kazamori, Daichi, Itoh, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Chromatography, Liquid Cysteine - analogs & derivatives Cysteine - pharmacology Cytochrome P-450 Enzyme Inhibitors - pharmacology Cytochrome P-450 Enzyme System - metabolism cytochrome P450 inhibition drug–drug interaction garlic Humans Microsomes, Liver - metabolism organosulfur compound Oxidation-Reduction Tandem Mass Spectrometry
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