Risk Reduction and Survival Benefit of Prophylactic Surgery in BRCA Mutation Carriers, A Systematic Review

Abstract Background Hereditary breast and ovarian cancer (HBOC) syndrome due to mutations in BRCA1/2 genes results in an elevated risk for developing both breast and ovarian cancer over the lifetime of affected carriers. General surgeons may be faced with questions about surgical risk reduction and...

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Veröffentlicht in:	The American journal of surgery 2016-10, Vol.212 (4), p.660-669
Hauptverfasser:	Ludwig, Kandice K., MD, Neuner, Joan, MD, MS, Butler, Annabelle, MD, Geurts, Jennifer L., MS, Kong, Amanda L., MD, MS
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA Breast cancer Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - prevention & control Female Genes Genes, BRCA1 Genes, BRCA2 Health risk assessment Heterozygote Hormone replacement therapy Humans Mammography Mastectomy Mortality Mutation Oophorectomy Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - mortality Ovarian Neoplasms - prevention & control Ovariectomy Prophylactic Prophylactic Mastectomy Prophylactic Surgical Procedures Risk reducing Salpingectomy Surgery
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