An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility

Abstract Background Genetic factors predispose individuals to attention-deficit/hyperactivity disorder (ADHD). Previous studies have reported linkage and association to ADHD of gene variants within ADGRL3 . In this study, we functionally analyzed noncoding variants in this gene as likely pathologica...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biological psychiatry (1969) 2016-12, Vol.80 (12), p.943-954
Hauptverfasser:	Martinez, Ariel F, Abe, Yu, Hong, Sungkook, Molyneux, Kevin, Yarnell, David, Löhr, Heiko, Driever, Wolfgang, Acosta, Maria T, Arcos-Burgos, Mauricio, Muenke, Maximilian
Format:	Artikel
Sprache:	eng
Schlagworte:	ADGRL3 ADHD Adolescent Adult Attention Deficit Disorder with Hyperactivity - genetics Child Child, Preschool Cis-acting regulatory element Enhancer Evolutionary conserved regions Female Genetic Predisposition to Disease Genetics Humans Latrophilin LPHN3 Male Pedigree Polymorphism, Single Nucleotide Psychiatry Receptors, G-Protein-Coupled - genetics Receptors, Peptide - genetics Young Adult Zebrafish
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!