Metabolic engineering of Corynebacterium glutamicum for shikimate overproduction by growth-arrested cell reaction

Corynebacterium glutamicum with the ability to simultaneously utilize glucose/pentose mixed sugars was metabolically engineered to overproduce shikimate, a valuable hydroaromatic compound used as a starting material for the synthesis of the anti-influenza drug oseltamivir. To achieve this, the shiki...

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Veröffentlicht in:Metabolic engineering 2016-11, Vol.38, p.204-216
Hauptverfasser: Kogure, Takahisa, Kubota, Takeshi, Suda, Masako, Hiraga, Kazumi, Inui, Masayuki
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Sprache:eng
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