Histone deacetylases inhibitors (HDACis) as novel therapeutic application in various clinical diseases

Accumulating evidence suggests that histone hypoacetylation which is partly mediated by histone deacetylase (HDAC), plays a causative role in the etiology of various clinical disorders such as cancer and central nervous diseases. HDAC inhibitors (HDACis) are natural or synthetic small molecules that...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2017-01, Vol.72, p.60-72
Hauptverfasser:	Qiu, Xiaoyan, Xiao, Xiong, Li, Nan, Li, Yuemin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Diseases - drug therapy Brain Diseases - enzymology Brain disorders Cancer Cell reprogramming Endometriosis HDACi Histone Deacetylase Inhibitors - therapeutic use Histone Deacetylases - metabolism Humans Neoplasms - drug therapy Neoplasms - enzymology
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