LODDS is Superior to Lymph Node Ratio for the Prognosis of Node-positive Rectal Cancer Patients Treated with Preoperative Radiotherapy
Purpose Yielding pathologic-lymph node ratio (yp-LNR) was considered to be a better staging system than yp-N stage in rectal cancer patients treated with preoperative radiotherapy (pre-RT). We aimed to compare the predictive ability of yielding pathologic log odds of positive lymph nodes (yp-LODDS)...
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| Veröffentlicht in: | Tumori 2017-01, Vol.103 (1), p.87-92 |
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| creator | Huang, Ben Ni, Mengdong Chen, Chen Cai, Guoxiang Cai, Sanjun |
| description | Purpose
Yielding pathologic-lymph node ratio (yp-LNR) was considered to be a better staging system than yp-N stage in rectal cancer patients treated with preoperative radiotherapy (pre-RT). We aimed to compare the predictive ability of yielding pathologic log odds of positive lymph nodes (yp-LODDS) with that of yp-LNR for cancer-specific survival (CSS) in stage III rectal cancer patients treated with pre-RT.
Methods
We analyzed stage III rectal cancer patients treated with pre-RT in the Surveillance, Epidemiology and End Results (SEER) database. Patients were classified into 4 groups, yp-LNR1 to 4, based on the LNR cutoff points 0.25, 0.50, and 0.75. Subjects were categorized into 5 groups, yp-LODDS1 to yp-LODDS5, based on the LODDS cutoff points −1, 0, 1, and 2. Univariate and multivariate Cox proportional hazards models were performed to analyze the risk factors for survival outcome.
Results
A total of 4,612 patients were included from the SEER database. Patients in the yp-LNR4 group could be further divided into yp-LODDS4 and yp-LODDS5 groups with 5-year CSS of 47.6% and 31.5%, respectively (p |
| doi_str_mv | 10.5301/tj.5000560 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1835368939</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.5301_tj.5000560</sage_id><sourcerecordid>1835368939</sourcerecordid><originalsourceid>FETCH-LOGICAL-c249t-baf1dffa027c73c2ec4e848466d8a63c69e9ff74b9c1c0597d8404b450b425463</originalsourceid><addsrcrecordid>eNptkMFO3DAQhq2qqCy0lz4A8g1UKXRiO459REsLSCtAhZ4jxxmzWe3GwXZa7Qv0uTHdLaeeRjPz_f9ofkI-l3BecSi_ptV5BQCVhHdkxoCrglVMvycz4ACF0qU8JEcxrgAEMCk_kENW16VUis_In8Xd5eUD7SN9mEYMvQ80ebrYbsYlvfUd0h8m9Z661_kS6X3wT4OPGffu774Yc5f6XxlEm8yazs1gMdD7LMMhRfoY0CTs6O8-LbMcfb5idgLT9T6bBjNuP5IDZ9YRP-3rMfn5_dvj_LpY3F3dzC8WhWVCp6I1ruycM8BqW3PL0ApUQgkpO2Ukt1Kjdq4WrbalhUrXnRIgWlFBK1glJD8mZzvfMfjnCWNqNn20uF6bAf0Um1Lxikuluc7olx1qg48xoGvG0G9M2DYlNK-5N2nV7HPP8Mned2o32L2h_4LOwOkOiOYJm5WfwpD__J_VCwRuixo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1835368939</pqid></control><display><type>article</type><title>LODDS is Superior to Lymph Node Ratio for the Prognosis of Node-positive Rectal Cancer Patients Treated with Preoperative Radiotherapy</title><source>SAGE Complete A-Z List</source><source>MEDLINE</source><creator>Huang, Ben ; Ni, Mengdong ; Chen, Chen ; Cai, Guoxiang ; Cai, Sanjun</creator><creatorcontrib>Huang, Ben ; Ni, Mengdong ; Chen, Chen ; Cai, Guoxiang ; Cai, Sanjun</creatorcontrib><description>Purpose
Yielding pathologic-lymph node ratio (yp-LNR) was considered to be a better staging system than yp-N stage in rectal cancer patients treated with preoperative radiotherapy (pre-RT). We aimed to compare the predictive ability of yielding pathologic log odds of positive lymph nodes (yp-LODDS) with that of yp-LNR for cancer-specific survival (CSS) in stage III rectal cancer patients treated with pre-RT.
Methods
We analyzed stage III rectal cancer patients treated with pre-RT in the Surveillance, Epidemiology and End Results (SEER) database. Patients were classified into 4 groups, yp-LNR1 to 4, based on the LNR cutoff points 0.25, 0.50, and 0.75. Subjects were categorized into 5 groups, yp-LODDS1 to yp-LODDS5, based on the LODDS cutoff points −1, 0, 1, and 2. Univariate and multivariate Cox proportional hazards models were performed to analyze the risk factors for survival outcome.
Results
A total of 4,612 patients were included from the SEER database. Patients in the yp-LNR4 group could be further divided into yp-LODDS4 and yp-LODDS5 groups with 5-year CSS of 47.6% and 31.5%, respectively (p<0.001). In the multivariate analysis without yp-LODDS, yp-LNR was an independent prognostic factor (hazard ratio [HR] 2.006, 95% confidence interval [CI] 1.619-2.484, p<0.001). However, after adjusting for yp-LODDS, yp-LNR was no longer associated with CSS (p = 0.393), and yp-LODDS was identified as an independent prognostic factor (HR 1.274, 95% CI 1.069-1.520, p = 0.007).
Conclusions
The prognostic value of yp-LNR can be confounded by yp-LODDS. In stage III rectal cancer patients treated with pre-RT, yp-LODDS has superior discrimination power over yp-LNR and can more accurately evaluate CSS.</description><identifier>ISSN: 0300-8916</identifier><identifier>EISSN: 2038-2529</identifier><identifier>DOI: 10.5301/tj.5000560</identifier><identifier>PMID: 27716883</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Female ; Humans ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Male ; Middle Aged ; Preoperative Care ; Prognosis ; Rectal Neoplasms - pathology ; Rectal Neoplasms - radiotherapy ; Rectal Neoplasms - surgery ; SEER Program</subject><ispartof>Tumori, 2017-01, Vol.103 (1), p.87-92</ispartof><rights>2017 SAGE Publications</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c249t-baf1dffa027c73c2ec4e848466d8a63c69e9ff74b9c1c0597d8404b450b425463</citedby><cites>FETCH-LOGICAL-c249t-baf1dffa027c73c2ec4e848466d8a63c69e9ff74b9c1c0597d8404b450b425463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.5301/tj.5000560$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.5301/tj.5000560$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27716883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Ben</creatorcontrib><creatorcontrib>Ni, Mengdong</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Cai, Guoxiang</creatorcontrib><creatorcontrib>Cai, Sanjun</creatorcontrib><title>LODDS is Superior to Lymph Node Ratio for the Prognosis of Node-positive Rectal Cancer Patients Treated with Preoperative Radiotherapy</title><title>Tumori</title><addtitle>Tumori</addtitle><description>Purpose
Yielding pathologic-lymph node ratio (yp-LNR) was considered to be a better staging system than yp-N stage in rectal cancer patients treated with preoperative radiotherapy (pre-RT). We aimed to compare the predictive ability of yielding pathologic log odds of positive lymph nodes (yp-LODDS) with that of yp-LNR for cancer-specific survival (CSS) in stage III rectal cancer patients treated with pre-RT.
Methods
We analyzed stage III rectal cancer patients treated with pre-RT in the Surveillance, Epidemiology and End Results (SEER) database. Patients were classified into 4 groups, yp-LNR1 to 4, based on the LNR cutoff points 0.25, 0.50, and 0.75. Subjects were categorized into 5 groups, yp-LODDS1 to yp-LODDS5, based on the LODDS cutoff points −1, 0, 1, and 2. Univariate and multivariate Cox proportional hazards models were performed to analyze the risk factors for survival outcome.
Results
A total of 4,612 patients were included from the SEER database. Patients in the yp-LNR4 group could be further divided into yp-LODDS4 and yp-LODDS5 groups with 5-year CSS of 47.6% and 31.5%, respectively (p<0.001). In the multivariate analysis without yp-LODDS, yp-LNR was an independent prognostic factor (hazard ratio [HR] 2.006, 95% confidence interval [CI] 1.619-2.484, p<0.001). However, after adjusting for yp-LODDS, yp-LNR was no longer associated with CSS (p = 0.393), and yp-LODDS was identified as an independent prognostic factor (HR 1.274, 95% CI 1.069-1.520, p = 0.007).
Conclusions
The prognostic value of yp-LNR can be confounded by yp-LODDS. In stage III rectal cancer patients treated with pre-RT, yp-LODDS has superior discrimination power over yp-LNR and can more accurately evaluate CSS.</description><subject>Female</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Preoperative Care</subject><subject>Prognosis</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - radiotherapy</subject><subject>Rectal Neoplasms - surgery</subject><subject>SEER Program</subject><issn>0300-8916</issn><issn>2038-2529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMFO3DAQhq2qqCy0lz4A8g1UKXRiO459REsLSCtAhZ4jxxmzWe3GwXZa7Qv0uTHdLaeeRjPz_f9ofkI-l3BecSi_ptV5BQCVhHdkxoCrglVMvycz4ACF0qU8JEcxrgAEMCk_kENW16VUis_In8Xd5eUD7SN9mEYMvQ80ebrYbsYlvfUd0h8m9Z661_kS6X3wT4OPGffu774Yc5f6XxlEm8yazs1gMdD7LMMhRfoY0CTs6O8-LbMcfb5idgLT9T6bBjNuP5IDZ9YRP-3rMfn5_dvj_LpY3F3dzC8WhWVCp6I1ruycM8BqW3PL0ApUQgkpO2Ukt1Kjdq4WrbalhUrXnRIgWlFBK1glJD8mZzvfMfjnCWNqNn20uF6bAf0Um1Lxikuluc7olx1qg48xoGvG0G9M2DYlNK-5N2nV7HPP8Mned2o32L2h_4LOwOkOiOYJm5WfwpD__J_VCwRuixo</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Huang, Ben</creator><creator>Ni, Mengdong</creator><creator>Chen, Chen</creator><creator>Cai, Guoxiang</creator><creator>Cai, Sanjun</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>LODDS is Superior to Lymph Node Ratio for the Prognosis of Node-positive Rectal Cancer Patients Treated with Preoperative Radiotherapy</title><author>Huang, Ben ; Ni, Mengdong ; Chen, Chen ; Cai, Guoxiang ; Cai, Sanjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c249t-baf1dffa027c73c2ec4e848466d8a63c69e9ff74b9c1c0597d8404b450b425463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Female</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Preoperative Care</topic><topic>Prognosis</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - radiotherapy</topic><topic>Rectal Neoplasms - surgery</topic><topic>SEER Program</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Ben</creatorcontrib><creatorcontrib>Ni, Mengdong</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Cai, Guoxiang</creatorcontrib><creatorcontrib>Cai, Sanjun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Tumori</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Ben</au><au>Ni, Mengdong</au><au>Chen, Chen</au><au>Cai, Guoxiang</au><au>Cai, Sanjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LODDS is Superior to Lymph Node Ratio for the Prognosis of Node-positive Rectal Cancer Patients Treated with Preoperative Radiotherapy</atitle><jtitle>Tumori</jtitle><addtitle>Tumori</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>103</volume><issue>1</issue><spage>87</spage><epage>92</epage><pages>87-92</pages><issn>0300-8916</issn><eissn>2038-2529</eissn><abstract>Purpose
Yielding pathologic-lymph node ratio (yp-LNR) was considered to be a better staging system than yp-N stage in rectal cancer patients treated with preoperative radiotherapy (pre-RT). We aimed to compare the predictive ability of yielding pathologic log odds of positive lymph nodes (yp-LODDS) with that of yp-LNR for cancer-specific survival (CSS) in stage III rectal cancer patients treated with pre-RT.
Methods
We analyzed stage III rectal cancer patients treated with pre-RT in the Surveillance, Epidemiology and End Results (SEER) database. Patients were classified into 4 groups, yp-LNR1 to 4, based on the LNR cutoff points 0.25, 0.50, and 0.75. Subjects were categorized into 5 groups, yp-LODDS1 to yp-LODDS5, based on the LODDS cutoff points −1, 0, 1, and 2. Univariate and multivariate Cox proportional hazards models were performed to analyze the risk factors for survival outcome.
Results
A total of 4,612 patients were included from the SEER database. Patients in the yp-LNR4 group could be further divided into yp-LODDS4 and yp-LODDS5 groups with 5-year CSS of 47.6% and 31.5%, respectively (p<0.001). In the multivariate analysis without yp-LODDS, yp-LNR was an independent prognostic factor (hazard ratio [HR] 2.006, 95% confidence interval [CI] 1.619-2.484, p<0.001). However, after adjusting for yp-LODDS, yp-LNR was no longer associated with CSS (p = 0.393), and yp-LODDS was identified as an independent prognostic factor (HR 1.274, 95% CI 1.069-1.520, p = 0.007).
Conclusions
The prognostic value of yp-LNR can be confounded by yp-LODDS. In stage III rectal cancer patients treated with pre-RT, yp-LODDS has superior discrimination power over yp-LNR and can more accurately evaluate CSS.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>27716883</pmid><doi>10.5301/tj.5000560</doi><tpages>6</tpages></addata></record> |
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| subjects | Female Humans Lymph Nodes - pathology Lymphatic Metastasis Male Middle Aged Preoperative Care Prognosis Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery SEER Program |
| title | LODDS is Superior to Lymph Node Ratio for the Prognosis of Node-positive Rectal Cancer Patients Treated with Preoperative Radiotherapy |
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