Genetic risk factors for antiepileptic drug–induced hypersensitivity reactions in Israeli populations

Summary The human leukocyte antigen (HLA) alleles B*15:02 and A*31:01 have been identified as predictive markers of adverse cutaneous effects of carbamazepine and phenytoin in Asian and North European populations, respectively. Our aim was to estimate the distribution of these alleles in Jewish and...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2016-10, Vol.57 (10), p.e205-e209
Hauptverfasser:	Israel, Shoshana, Maggio, Nicola, Ekstein, Dana, Zaid, Huda, Firer, Maria, Bederovsky, Yana, Noyman, Iris, Gandelman‐Marton, Revital, Blatt, Ilan, Brautbar, Chaim, Marom, Eli, Nahlieli Dil, Dorit, Berman, Erez, Sabag, David, Ingber, Arieh, Eyal, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - adverse effects Arabs Arab‐Muslim Carbamazepine Drug Hypersensitivity - epidemiology Drug Hypersensitivity - ethnology Drug Hypersensitivity - etiology Drug Hypersensitivity - genetics Epilepsy - drug therapy Epilepsy - ethnology Female Genetic Predisposition to Disease - genetics HLA-A Antigens - genetics HLA-B Antigens - genetics HLA‐A31:01 HLA‐B15:02 Humans Incidence Israel - epidemiology Israel - ethnology Jewish Jewish people Jews Male Prescription drugs Retrospective Studies Risk Factors Side effects Stevens‐Johnson syndrome
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