Allograft plus OP-1 enhances ossification in posterolateral lumbar fusion: A seven year follow-up
ABSTRACT Purpose To study the results of the combination of allograft plus BMP-7 in comparison with allograft alone in posterolateral lumbar arthrodesis. Patients and Methods A blinded controlled consecutive prospective cohort of skeletally mature patients study. One hundred and ten patients underwe...
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| Veröffentlicht in: | Injury 2016-09, Vol.47, p.S78-S82 |
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| creator | Guerado, Enrique Cervan, Ana M Bertrand, Maria L Benitez-Parejo, Nicolas |
| description | ABSTRACT Purpose To study the results of the combination of allograft plus BMP-7 in comparison with allograft alone in posterolateral lumbar arthrodesis. Patients and Methods A blinded controlled consecutive prospective cohort of skeletally mature patients study. One hundred and ten patients underwent posterolateral lumbar instrumented arthrodesis. Allograft randomly compacted onto either the right or the left side of the articular and the posterior aspect of the transverse processes of lumbar spine. The same procedure performed on the contralateral side, but allograft was previously mixed with osteogenic protein (OP-1). Clinical, x-ray and CT-scan long follow-up performed. Univariable and multivariable logistic regression analyses. Results More bone continuity was found with allograft plus OP-1 than with allograft alone ( p > 0.0038). The amount of bone mass was greater on the OP-1 side ( p < 0.001). No local or systemic adverse effect were noted. Conclusions Allograft on one side plus allograft with BMP-7 on the other achieved a fusion rate of 93 per cent. Allograft combined with BMP-7 was more effective than allograft alone. |
| doi_str_mv | 10.1016/S0020-1383(16)30611-8 |
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Patients and Methods A blinded controlled consecutive prospective cohort of skeletally mature patients study. One hundred and ten patients underwent posterolateral lumbar instrumented arthrodesis. Allograft randomly compacted onto either the right or the left side of the articular and the posterior aspect of the transverse processes of lumbar spine. The same procedure performed on the contralateral side, but allograft was previously mixed with osteogenic protein (OP-1). Clinical, x-ray and CT-scan long follow-up performed. Univariable and multivariable logistic regression analyses. Results More bone continuity was found with allograft plus OP-1 than with allograft alone ( p > 0.0038). The amount of bone mass was greater on the OP-1 side ( p < 0.001). No local or systemic adverse effect were noted. Conclusions Allograft on one side plus allograft with BMP-7 on the other achieved a fusion rate of 93 per cent. Allograft combined with BMP-7 was more effective than allograft alone.</description><identifier>ISSN: 0020-1383</identifier><identifier>EISSN: 1879-0267</identifier><identifier>DOI: 10.1016/S0020-1383(16)30611-8</identifier><identifier>PMID: 27692113</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Aged ; Allograft ; Allografts ; Arthrodesis - methods ; BMP ; Bone Morphogenetic Protein 7 - therapeutic use ; Bone Substitutes - therapeutic use ; Female ; Follow-Up Studies ; Fusion ; Growth factors ; Humans ; Instrumentation ; Lumbar spine ; Lumbar Vertebrae - diagnostic imaging ; Lumbar Vertebrae - injuries ; Lumbar Vertebrae - surgery ; Lumbosacral Region - diagnostic imaging ; Lumbosacral Region - pathology ; Male ; Middle Aged ; Orthopedics ; Osseointegration - drug effects ; Prospective Studies ; Radiography ; Spinal arthrodesis ; Spinal Fusion - instrumentation ; Spinal Fusion - methods ; Treatment Outcome ; Young Adult</subject><ispartof>Injury, 2016-09, Vol.47, p.S78-S82</ispartof><rights>Elsevier Ltd</rights><rights>2016 Elsevier Ltd</rights><rights>2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-eba987f01105f0f863b0b04029c7a3e19a7deed256bc82582999a8e51b0412263</citedby><cites>FETCH-LOGICAL-c420t-eba987f01105f0f863b0b04029c7a3e19a7deed256bc82582999a8e51b0412263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0020-1383(16)30611-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27692113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guerado, Enrique</creatorcontrib><creatorcontrib>Cervan, Ana M</creatorcontrib><creatorcontrib>Bertrand, Maria L</creatorcontrib><creatorcontrib>Benitez-Parejo, Nicolas</creatorcontrib><title>Allograft plus OP-1 enhances ossification in posterolateral lumbar fusion: A seven year follow-up</title><title>Injury</title><addtitle>Injury</addtitle><description>ABSTRACT Purpose To study the results of the combination of allograft plus BMP-7 in comparison with allograft alone in posterolateral lumbar arthrodesis. Patients and Methods A blinded controlled consecutive prospective cohort of skeletally mature patients study. One hundred and ten patients underwent posterolateral lumbar instrumented arthrodesis. Allograft randomly compacted onto either the right or the left side of the articular and the posterior aspect of the transverse processes of lumbar spine. The same procedure performed on the contralateral side, but allograft was previously mixed with osteogenic protein (OP-1). Clinical, x-ray and CT-scan long follow-up performed. Univariable and multivariable logistic regression analyses. Results More bone continuity was found with allograft plus OP-1 than with allograft alone ( p > 0.0038). The amount of bone mass was greater on the OP-1 side ( p < 0.001). No local or systemic adverse effect were noted. Conclusions Allograft on one side plus allograft with BMP-7 on the other achieved a fusion rate of 93 per cent. Allograft combined with BMP-7 was more effective than allograft alone.</description><subject>Adult</subject><subject>Aged</subject><subject>Allograft</subject><subject>Allografts</subject><subject>Arthrodesis - methods</subject><subject>BMP</subject><subject>Bone Morphogenetic Protein 7 - therapeutic use</subject><subject>Bone Substitutes - therapeutic use</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fusion</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Instrumentation</subject><subject>Lumbar spine</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - injuries</subject><subject>Lumbar Vertebrae - surgery</subject><subject>Lumbosacral Region - diagnostic imaging</subject><subject>Lumbosacral Region - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>Osseointegration - drug effects</subject><subject>Prospective Studies</subject><subject>Radiography</subject><subject>Spinal arthrodesis</subject><subject>Spinal Fusion - instrumentation</subject><subject>Spinal Fusion - methods</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0020-1383</issn><issn>1879-0267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhJ4B8LIfAjN04DgeqVcWXVKlIwNlynAm4eONgJ0X773F2Sw9cuNiy_c4zmseMPUd4hYDq9RcAARVKLc9QvZSgECv9gG1QN20FQjUP2eY-csKe5HwDgA1I-ZidiEa1AlFumN2GEL8nO8x8Ckvm158r5DT-sKOjzGPOfvDOzj6O3I98inmmFIMtqw08LLvOJj4suby_4Vue6ZZGvqf1Mhbw72qZnrJHgw2Znt3tp-zb-3dfLz9WV9cfPl1uryp3LmCuqLOtbgZAhHqAQSvZQQfnIFrXWEnY2qYn6kWtOqdFrUXbtlZTjSWEQih5ys6O3CnFXwvl2ex8dhSCHSku2aCWtVRSqzVaH6MulQkTDWZKfmfT3iCY1a452DWrOlNOB7tGl7oXdy2Wbkf9fdVfnSVwcQxQGfTWUzLZeSoqe5_IzaaP_r8t3v5DcMGP5QvCT9pTvolLGotFgyYLA0fIykB1IGj5B7Dvnas</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Guerado, Enrique</creator><creator>Cervan, Ana M</creator><creator>Bertrand, Maria L</creator><creator>Benitez-Parejo, Nicolas</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>Allograft plus OP-1 enhances ossification in posterolateral lumbar fusion: A seven year follow-up</title><author>Guerado, Enrique ; Cervan, Ana M ; Bertrand, Maria L ; Benitez-Parejo, Nicolas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-eba987f01105f0f863b0b04029c7a3e19a7deed256bc82582999a8e51b0412263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allograft</topic><topic>Allografts</topic><topic>Arthrodesis - methods</topic><topic>BMP</topic><topic>Bone Morphogenetic Protein 7 - therapeutic use</topic><topic>Bone Substitutes - therapeutic use</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fusion</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Instrumentation</topic><topic>Lumbar spine</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - injuries</topic><topic>Lumbar Vertebrae - surgery</topic><topic>Lumbosacral Region - diagnostic imaging</topic><topic>Lumbosacral Region - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Orthopedics</topic><topic>Osseointegration - drug effects</topic><topic>Prospective Studies</topic><topic>Radiography</topic><topic>Spinal arthrodesis</topic><topic>Spinal Fusion - instrumentation</topic><topic>Spinal Fusion - methods</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guerado, Enrique</creatorcontrib><creatorcontrib>Cervan, Ana M</creatorcontrib><creatorcontrib>Bertrand, Maria L</creatorcontrib><creatorcontrib>Benitez-Parejo, Nicolas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Injury</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guerado, Enrique</au><au>Cervan, Ana M</au><au>Bertrand, Maria L</au><au>Benitez-Parejo, Nicolas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allograft plus OP-1 enhances ossification in posterolateral lumbar fusion: A seven year follow-up</atitle><jtitle>Injury</jtitle><addtitle>Injury</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>47</volume><spage>S78</spage><epage>S82</epage><pages>S78-S82</pages><issn>0020-1383</issn><eissn>1879-0267</eissn><abstract>ABSTRACT Purpose To study the results of the combination of allograft plus BMP-7 in comparison with allograft alone in posterolateral lumbar arthrodesis. Patients and Methods A blinded controlled consecutive prospective cohort of skeletally mature patients study. One hundred and ten patients underwent posterolateral lumbar instrumented arthrodesis. Allograft randomly compacted onto either the right or the left side of the articular and the posterior aspect of the transverse processes of lumbar spine. The same procedure performed on the contralateral side, but allograft was previously mixed with osteogenic protein (OP-1). Clinical, x-ray and CT-scan long follow-up performed. Univariable and multivariable logistic regression analyses. Results More bone continuity was found with allograft plus OP-1 than with allograft alone ( p > 0.0038). The amount of bone mass was greater on the OP-1 side ( p < 0.001). No local or systemic adverse effect were noted. Conclusions Allograft on one side plus allograft with BMP-7 on the other achieved a fusion rate of 93 per cent. Allograft combined with BMP-7 was more effective than allograft alone.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>27692113</pmid><doi>10.1016/S0020-1383(16)30611-8</doi></addata></record> |
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| subjects | Adult Aged Allograft Allografts Arthrodesis - methods BMP Bone Morphogenetic Protein 7 - therapeutic use Bone Substitutes - therapeutic use Female Follow-Up Studies Fusion Growth factors Humans Instrumentation Lumbar spine Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - injuries Lumbar Vertebrae - surgery Lumbosacral Region - diagnostic imaging Lumbosacral Region - pathology Male Middle Aged Orthopedics Osseointegration - drug effects Prospective Studies Radiography Spinal arthrodesis Spinal Fusion - instrumentation Spinal Fusion - methods Treatment Outcome Young Adult |
| title | Allograft plus OP-1 enhances ossification in posterolateral lumbar fusion: A seven year follow-up |
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