A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing
Current paper‐based potentiometric ion‐sensing platforms are planar devices used for clinically relevant ions. These devices, however, have not been designed for the potentiometric biosensing of proteins or small molecule analytes. A three‐dimensional origami paper‐based device, in which a solid‐con...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2016-10, Vol.55 (42), p.13033-13037 |
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| creator | Ding, Jiawang Li, Bowei Chen, Lingxin Qin, Wei |
| description | Current paper‐based potentiometric ion‐sensing platforms are planar devices used for clinically relevant ions. These devices, however, have not been designed for the potentiometric biosensing of proteins or small molecule analytes. A three‐dimensional origami paper‐based device, in which a solid‐contact ion‐selective electrode is integrated with an all‐solid‐state reference electrode, is described for the first time. The device is made by impregnation of paper with appropriate bioreceptors and reporting reagents on different zones. By folding and unfolding the paper structures, versatile potentiometric bioassays can be performed. A USB‐controlled miniaturized electrochemical detector can be used for simple and in situ measurements. Using butyrylcholinesterase as a model enzyme, the device has been successfully applied to the detection of enzyme activities and organophosphate pesticides involved in the enzymatic system as inhibitors. The proposed 3D origami paper device allows the potentiometric biosensing of proteins and small molecules in a simple, portable, and cost‐effective way.
Assays on folding paper have potential: A three‐dimensional origami paper‐based device, in which a solid‐contact ion‐selective electrode is integrated with an all‐solid‐state reference electrode, has been developed for potentiometric biosensing. |
| doi_str_mv | 10.1002/anie.201606268 |
| format | Article |
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Assays on folding paper have potential: A three‐dimensional origami paper‐based device, in which a solid‐contact ion‐selective electrode is integrated with an all‐solid‐state reference electrode, has been developed for potentiometric biosensing.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201606268</identifier><identifier>PMID: 27634584</identifier><identifier>CODEN: ACIEAY</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Agrochemicals ; Bioassays ; Biosensors ; Corrosion inhibitors ; Data buses ; Detection ; Devices ; Dimensional analysis ; Electrochemistry ; enzyme-based assays ; Enzymes ; Folding ; Impregnation ; Inhibitors ; Ions ; Mathematical models ; Organophosphorus pesticides ; origami paper-based devices ; Pesticides ; Platforms ; Portability ; potentiometry ; Proteins ; Reagents</subject><ispartof>Angewandte Chemie International Edition, 2016-10, Vol.55 (42), p.13033-13037</ispartof><rights>2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5828-e5fb389ee3a4769b3766d16ba67d2041b9edb9019011cdf9d5cdeb7f48cb71333</citedby><cites>FETCH-LOGICAL-c5828-e5fb389ee3a4769b3766d16ba67d2041b9edb9019011cdf9d5cdeb7f48cb71333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201606268$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201606268$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27634584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ding, Jiawang</creatorcontrib><creatorcontrib>Li, Bowei</creatorcontrib><creatorcontrib>Chen, Lingxin</creatorcontrib><creatorcontrib>Qin, Wei</creatorcontrib><title>A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing</title><title>Angewandte Chemie International Edition</title><addtitle>Angew. Chem. Int. Ed</addtitle><description>Current paper‐based potentiometric ion‐sensing platforms are planar devices used for clinically relevant ions. These devices, however, have not been designed for the potentiometric biosensing of proteins or small molecule analytes. A three‐dimensional origami paper‐based device, in which a solid‐contact ion‐selective electrode is integrated with an all‐solid‐state reference electrode, is described for the first time. The device is made by impregnation of paper with appropriate bioreceptors and reporting reagents on different zones. By folding and unfolding the paper structures, versatile potentiometric bioassays can be performed. A USB‐controlled miniaturized electrochemical detector can be used for simple and in situ measurements. Using butyrylcholinesterase as a model enzyme, the device has been successfully applied to the detection of enzyme activities and organophosphate pesticides involved in the enzymatic system as inhibitors. The proposed 3D origami paper device allows the potentiometric biosensing of proteins and small molecules in a simple, portable, and cost‐effective way.
Assays on folding paper have potential: A three‐dimensional origami paper‐based device, in which a solid‐contact ion‐selective electrode is integrated with an all‐solid‐state reference electrode, has been developed for potentiometric biosensing.</description><subject>Agrochemicals</subject><subject>Bioassays</subject><subject>Biosensors</subject><subject>Corrosion inhibitors</subject><subject>Data buses</subject><subject>Detection</subject><subject>Devices</subject><subject>Dimensional analysis</subject><subject>Electrochemistry</subject><subject>enzyme-based assays</subject><subject>Enzymes</subject><subject>Folding</subject><subject>Impregnation</subject><subject>Inhibitors</subject><subject>Ions</subject><subject>Mathematical models</subject><subject>Organophosphorus pesticides</subject><subject>origami paper-based devices</subject><subject>Pesticides</subject><subject>Platforms</subject><subject>Portability</subject><subject>potentiometry</subject><subject>Proteins</subject><subject>Reagents</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkc2P0zAQxS0EYj_gyhFF4sIlxfYkY_vY7rdU7fZQtEfLSSaLlyQudgrsf0-qLhXiANJIM4ffe6OZx9g7wWeCc_nJDZ5mkgvkKFG_YMeilCIHpeDlNBcAudKlOGInKT1OvNYcX7MjqRCKUhfHbDnP1l8iUX7uexqSD4PrsrvoH1zvs5XbUMwXLlGTndN3X1PWhpitwkjD6ENPY_R1tvAh7aTDwxv2qnVdorfP_ZR9vrxYn13ny7urm7P5Mq9LLXVOZVuBNkTgCoWmAoXYCKwcqkbyQlSGmspwMZWom9Y0Zd1QpdpC15USAHDKPu59NzF821Iabe9TTV3nBgrbZIWGEpBLIyf0w1_oY9jG6ciJMhwLJTXwf1JaIjcIuFs721N1DClFau0m-t7FJyu43aVhd2nYQxqT4P2z7bbqqTngv98_AWYP_PAdPf3Hzs5vby7-NM_3Wp9G-nnQuvjVogJV2vvbK7uSi2u5xHu7hl9qHKNo</recordid><startdate>20161010</startdate><enddate>20161010</enddate><creator>Ding, Jiawang</creator><creator>Li, Bowei</creator><creator>Chen, Lingxin</creator><creator>Qin, Wei</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20161010</creationdate><title>A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing</title><author>Ding, Jiawang ; Li, Bowei ; Chen, Lingxin ; Qin, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5828-e5fb389ee3a4769b3766d16ba67d2041b9edb9019011cdf9d5cdeb7f48cb71333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Agrochemicals</topic><topic>Bioassays</topic><topic>Biosensors</topic><topic>Corrosion inhibitors</topic><topic>Data buses</topic><topic>Detection</topic><topic>Devices</topic><topic>Dimensional analysis</topic><topic>Electrochemistry</topic><topic>enzyme-based assays</topic><topic>Enzymes</topic><topic>Folding</topic><topic>Impregnation</topic><topic>Inhibitors</topic><topic>Ions</topic><topic>Mathematical models</topic><topic>Organophosphorus pesticides</topic><topic>origami paper-based devices</topic><topic>Pesticides</topic><topic>Platforms</topic><topic>Portability</topic><topic>potentiometry</topic><topic>Proteins</topic><topic>Reagents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Jiawang</creatorcontrib><creatorcontrib>Li, Bowei</creatorcontrib><creatorcontrib>Chen, Lingxin</creatorcontrib><creatorcontrib>Qin, Wei</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Jiawang</au><au>Li, Bowei</au><au>Chen, Lingxin</au><au>Qin, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew. Chem. Int. Ed</addtitle><date>2016-10-10</date><risdate>2016</risdate><volume>55</volume><issue>42</issue><spage>13033</spage><epage>13037</epage><pages>13033-13037</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><coden>ACIEAY</coden><abstract>Current paper‐based potentiometric ion‐sensing platforms are planar devices used for clinically relevant ions. These devices, however, have not been designed for the potentiometric biosensing of proteins or small molecule analytes. A three‐dimensional origami paper‐based device, in which a solid‐contact ion‐selective electrode is integrated with an all‐solid‐state reference electrode, is described for the first time. The device is made by impregnation of paper with appropriate bioreceptors and reporting reagents on different zones. By folding and unfolding the paper structures, versatile potentiometric bioassays can be performed. A USB‐controlled miniaturized electrochemical detector can be used for simple and in situ measurements. Using butyrylcholinesterase as a model enzyme, the device has been successfully applied to the detection of enzyme activities and organophosphate pesticides involved in the enzymatic system as inhibitors. The proposed 3D origami paper device allows the potentiometric biosensing of proteins and small molecules in a simple, portable, and cost‐effective way.
Assays on folding paper have potential: A three‐dimensional origami paper‐based device, in which a solid‐contact ion‐selective electrode is integrated with an all‐solid‐state reference electrode, has been developed for potentiometric biosensing.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>27634584</pmid><doi>10.1002/anie.201606268</doi><tpages>5</tpages><edition>International ed. in English</edition><oa>free_for_read</oa></addata></record> |
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| subjects | Agrochemicals Bioassays Biosensors Corrosion inhibitors Data buses Detection Devices Dimensional analysis Electrochemistry enzyme-based assays Enzymes Folding Impregnation Inhibitors Ions Mathematical models Organophosphorus pesticides origami paper-based devices Pesticides Platforms Portability potentiometry Proteins Reagents |
| title | A Three-Dimensional Origami Paper-Based Device for Potentiometric Biosensing |
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