The antitumour drug 7-ethyl-10-hydroxycamptothecin monohydrate and its solid-state hydrolysis mechanism on heating

7‐Ethyl‐10‐hydroxycamptothecin [systematic name: (4S)‐4,11‐diethyl‐4,9‐dihydroxy‐1H‐pyrano[3′,4′:6,7]indolizino[1,2‐b]quinoline‐3,14(4H,12H)‐dione, SN‐38] is an antitumour drug which exerts activity through the inhibition of topoisomerase I. The crystal structure of SN‐38 as the monohydrate, C22H20N...

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Veröffentlicht in:	Acta crystallographica. Section C, Crystal structure communications Crystal structure communications, 2016-10, Vol.72 (10), p.743-747
Hauptverfasser:	Ali, Md. Ashraf, Noguchi, Shuji, Watanabe, Miteki, Iwao, Yasunori, Itai, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	7-ethyl-10-hydroxycamptothecin anticancer agent antitumour drugs Crystal structure Drug therapy Heating irinotecan solid-state hydrolysis synchrotron topoisomerase I inhibitor
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