Perineural invasion on biopsy is associated with upstaging at radical prostatectomy in Gleason score 3 + 4 = 7 prostate cancer
This study assesses if perineural invasion (PNI) detected on biopsy with Gleason score (GS) 3 + 4 = 7 prostate cancer (PCa) is associated with upstaging/upgrading of disease after radical prostatectomy (RP). 154 patients with GS 3 + 4 = 7 PCa diagnosed from biopsy who underwent RP were assessed for...
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| Veröffentlicht in: | Pathology international 2016-11, Vol.66 (11), p.629-632 |
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| creator | Flood, Trevor A. Schieda, Nicola Keefe, Daniel T. Morash, Chris Bateman, Justin Mai, Kien T. Belanger, Eric C. Robertson, Susan J. Breau, Rodney H. |
| description | This study assesses if perineural invasion (PNI) detected on biopsy with Gleason score (GS) 3 + 4 = 7 prostate cancer (PCa) is associated with upstaging/upgrading of disease after radical prostatectomy (RP). 154 patients with GS 3 + 4 = 7 PCa diagnosed from biopsy who underwent RP were assessed for PNI. The percentage of biopsy sites with PNI (%PNI) was also calculated. Pattern 4 morphologies (ill‐defined glands [IDG], fused, cribriform, and glomerulations) were also assessed. Clinical information, GS and stage after RP were retrieved from the medical records. 45 % (69/154) of patients were upstaged (≥pT3) and 29 % (44/154) were upgraded to GS >3 + 4 = 7 after RP. 37 % (57/154) of patients had PNI which was associated with upstaging (RR 1.4; P = 0.04) but not upgrading (RR 0.9; P = 0.7). There was higher %PNI in upstaged patients (12.1 % ± 1.8 vs. 7.1 % ± 1.5, P = 0.03) with a significant correlation between %PNI and ≥pT3 (r = 0.178, P = 0.027). After multivariate analysis, only cribriform formations were significantly associated with upstaging (P = 0.009). The presence of PNI in biopsies with GS 3 + 4 = 7 PCa is associated with upstaging at RP but is a weaker predictor of ≥pT3 disease than cribriform morphology. |
| doi_str_mv | 10.1111/pin.12467 |
| format | Article |
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The percentage of biopsy sites with PNI (%PNI) was also calculated. Pattern 4 morphologies (ill‐defined glands [IDG], fused, cribriform, and glomerulations) were also assessed. Clinical information, GS and stage after RP were retrieved from the medical records. 45 % (69/154) of patients were upstaged (≥pT3) and 29 % (44/154) were upgraded to GS >3 + 4 = 7 after RP. 37 % (57/154) of patients had PNI which was associated with upstaging (RR 1.4; P = 0.04) but not upgrading (RR 0.9; P = 0.7). There was higher %PNI in upstaged patients (12.1 % ± 1.8 vs. 7.1 % ± 1.5, P = 0.03) with a significant correlation between %PNI and ≥pT3 (r = 0.178, P = 0.027). After multivariate analysis, only cribriform formations were significantly associated with upstaging (P = 0.009). The presence of PNI in biopsies with GS 3 + 4 = 7 PCa is associated with upstaging at RP but is a weaker predictor of ≥pT3 disease than cribriform morphology.</description><identifier>ISSN: 1320-5463</identifier><identifier>EISSN: 1440-1827</identifier><identifier>DOI: 10.1111/pin.12467</identifier><identifier>PMID: 27709739</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>active surveillance ; Biopsy ; Gleason grade ; Humans ; Male ; Neoplasm Grading ; perineural invasion ; prostate ; prostate biopsy ; prostate cancer ; Prostatectomy ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; radical prostatectomy</subject><ispartof>Pathology international, 2016-11, Vol.66 (11), p.629-632</ispartof><rights>2016 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd</rights><rights>2016 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3877-756da2778a93d38e31b2138507ccdbbe03122f535e1748e11e143144049ef4e93</citedby><cites>FETCH-LOGICAL-c3877-756da2778a93d38e31b2138507ccdbbe03122f535e1748e11e143144049ef4e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpin.12467$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpin.12467$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27709739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flood, Trevor A.</creatorcontrib><creatorcontrib>Schieda, Nicola</creatorcontrib><creatorcontrib>Keefe, Daniel T.</creatorcontrib><creatorcontrib>Morash, Chris</creatorcontrib><creatorcontrib>Bateman, Justin</creatorcontrib><creatorcontrib>Mai, Kien T.</creatorcontrib><creatorcontrib>Belanger, Eric C.</creatorcontrib><creatorcontrib>Robertson, Susan J.</creatorcontrib><creatorcontrib>Breau, Rodney H.</creatorcontrib><title>Perineural invasion on biopsy is associated with upstaging at radical prostatectomy in Gleason score 3 + 4 = 7 prostate cancer</title><title>Pathology international</title><addtitle>Pathology International</addtitle><description>This study assesses if perineural invasion (PNI) detected on biopsy with Gleason score (GS) 3 + 4 = 7 prostate cancer (PCa) is associated with upstaging/upgrading of disease after radical prostatectomy (RP). 154 patients with GS 3 + 4 = 7 PCa diagnosed from biopsy who underwent RP were assessed for PNI. The percentage of biopsy sites with PNI (%PNI) was also calculated. Pattern 4 morphologies (ill‐defined glands [IDG], fused, cribriform, and glomerulations) were also assessed. Clinical information, GS and stage after RP were retrieved from the medical records. 45 % (69/154) of patients were upstaged (≥pT3) and 29 % (44/154) were upgraded to GS >3 + 4 = 7 after RP. 37 % (57/154) of patients had PNI which was associated with upstaging (RR 1.4; P = 0.04) but not upgrading (RR 0.9; P = 0.7). There was higher %PNI in upstaged patients (12.1 % ± 1.8 vs. 7.1 % ± 1.5, P = 0.03) with a significant correlation between %PNI and ≥pT3 (r = 0.178, P = 0.027). After multivariate analysis, only cribriform formations were significantly associated with upstaging (P = 0.009). The presence of PNI in biopsies with GS 3 + 4 = 7 PCa is associated with upstaging at RP but is a weaker predictor of ≥pT3 disease than cribriform morphology.</description><subject>active surveillance</subject><subject>Biopsy</subject><subject>Gleason grade</subject><subject>Humans</subject><subject>Male</subject><subject>Neoplasm Grading</subject><subject>perineural invasion</subject><subject>prostate</subject><subject>prostate biopsy</subject><subject>prostate cancer</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>radical prostatectomy</subject><issn>1320-5463</issn><issn>1440-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1OxCAURonR-L_wBQxLjalCoQNduNCJjpqJutC4JJTeUbTTVmjV2fjsXh2dnYQEAuf7IIeQHc4OOY6j1teHPJUDtUTWuZQs4TpVy7gXKUsyORBrZCPGZ8a4EgO2StZSpViuRL5OPm8h-Br6YCvq6zcbfVNTnIVv2jijPlIbY-O87aCk7757on0bO_vo60dqOxps6R1G29DgaQeua6aYqumoAhuxJ7omABX0gEp6TNUCpM7WDsIWWZnYKsL277pJ7s_P7oYXyfhmdDk8GSdOaKUSlQ1Ki5_WNhel0CB4kXKhM6acK4sCmOBpOslEBlxJDZwDl-LbhMxhIiEXm2Rv3ovvv_YQOzP10UFV2RqaPhquBaa11hmi-3PU4VdjgIlpg5_aMDOcmW_dBnWbH93I7v7W9sUUygX55xeBoznw7iuY_d9kbi-v_yqTecLHDj4WCRteDN6qzDxcj8z46mHMUIo5FV9yQJgo</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Flood, Trevor A.</creator><creator>Schieda, Nicola</creator><creator>Keefe, Daniel T.</creator><creator>Morash, Chris</creator><creator>Bateman, Justin</creator><creator>Mai, Kien T.</creator><creator>Belanger, Eric C.</creator><creator>Robertson, Susan J.</creator><creator>Breau, Rodney H.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201611</creationdate><title>Perineural invasion on biopsy is associated with upstaging at radical prostatectomy in Gleason score 3 + 4 = 7 prostate cancer</title><author>Flood, Trevor A. ; Schieda, Nicola ; Keefe, Daniel T. ; Morash, Chris ; Bateman, Justin ; Mai, Kien T. ; Belanger, Eric C. ; Robertson, Susan J. ; Breau, Rodney H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3877-756da2778a93d38e31b2138507ccdbbe03122f535e1748e11e143144049ef4e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>active surveillance</topic><topic>Biopsy</topic><topic>Gleason grade</topic><topic>Humans</topic><topic>Male</topic><topic>Neoplasm Grading</topic><topic>perineural invasion</topic><topic>prostate</topic><topic>prostate biopsy</topic><topic>prostate cancer</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>radical prostatectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flood, Trevor A.</creatorcontrib><creatorcontrib>Schieda, Nicola</creatorcontrib><creatorcontrib>Keefe, Daniel T.</creatorcontrib><creatorcontrib>Morash, Chris</creatorcontrib><creatorcontrib>Bateman, Justin</creatorcontrib><creatorcontrib>Mai, Kien T.</creatorcontrib><creatorcontrib>Belanger, Eric C.</creatorcontrib><creatorcontrib>Robertson, Susan J.</creatorcontrib><creatorcontrib>Breau, Rodney H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flood, Trevor A.</au><au>Schieda, Nicola</au><au>Keefe, Daniel T.</au><au>Morash, Chris</au><au>Bateman, Justin</au><au>Mai, Kien T.</au><au>Belanger, Eric C.</au><au>Robertson, Susan J.</au><au>Breau, Rodney H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perineural invasion on biopsy is associated with upstaging at radical prostatectomy in Gleason score 3 + 4 = 7 prostate cancer</atitle><jtitle>Pathology international</jtitle><addtitle>Pathology International</addtitle><date>2016-11</date><risdate>2016</risdate><volume>66</volume><issue>11</issue><spage>629</spage><epage>632</epage><pages>629-632</pages><issn>1320-5463</issn><eissn>1440-1827</eissn><abstract>This study assesses if perineural invasion (PNI) detected on biopsy with Gleason score (GS) 3 + 4 = 7 prostate cancer (PCa) is associated with upstaging/upgrading of disease after radical prostatectomy (RP). 154 patients with GS 3 + 4 = 7 PCa diagnosed from biopsy who underwent RP were assessed for PNI. The percentage of biopsy sites with PNI (%PNI) was also calculated. Pattern 4 morphologies (ill‐defined glands [IDG], fused, cribriform, and glomerulations) were also assessed. Clinical information, GS and stage after RP were retrieved from the medical records. 45 % (69/154) of patients were upstaged (≥pT3) and 29 % (44/154) were upgraded to GS >3 + 4 = 7 after RP. 37 % (57/154) of patients had PNI which was associated with upstaging (RR 1.4; P = 0.04) but not upgrading (RR 0.9; P = 0.7). There was higher %PNI in upstaged patients (12.1 % ± 1.8 vs. 7.1 % ± 1.5, P = 0.03) with a significant correlation between %PNI and ≥pT3 (r = 0.178, P = 0.027). After multivariate analysis, only cribriform formations were significantly associated with upstaging (P = 0.009). The presence of PNI in biopsies with GS 3 + 4 = 7 PCa is associated with upstaging at RP but is a weaker predictor of ≥pT3 disease than cribriform morphology.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>27709739</pmid><doi>10.1111/pin.12467</doi><tpages>4</tpages></addata></record> |
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| subjects | active surveillance Biopsy Gleason grade Humans Male Neoplasm Grading perineural invasion prostate prostate biopsy prostate cancer Prostatectomy Prostatic Neoplasms - diagnosis Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery radical prostatectomy |
| title | Perineural invasion on biopsy is associated with upstaging at radical prostatectomy in Gleason score 3 + 4 = 7 prostate cancer |
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