Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution

In HLA-DQ8-associated celiac disease, TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ T cells recognize the immunodominant DQ8-glia-α1 epitope, whereupon a non-germline-encoded arginine residue played a key role in binding HLA-DQ8-glia-α1. Whether distinct T cell receptor (TCR) recognition modes exist for glia...

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Veröffentlicht in:	Structure (London) 2016-10, Vol.24 (10), p.1643-1657
Hauptverfasser:	Petersen, Jan, Kooy-Winkelaar, Yvonne, Loh, Khai Lee, Tran, Mai, van Bergen, Jeroen, Koning, Frits, Rossjohn, Jamie, Reid, Hugh H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen Presentation Celiac Disease - immunology Cells, Cultured Gliadin - immunology HLA-DQ Antigens - chemistry HLA-DQ Antigens - genetics HLA-DQ Antigens - metabolism Humans Immunodominant Epitopes Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism T-Lymphocytes - cytology T-Lymphocytes - immunology
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