Safety assessment and attenuation of cisplatin induced nephrotoxicity by tuberous roots of Boerhaavia diffusa
Cisplatin (Cis-diaminedichloroplatinum II) is a chemotherapeutic agent having well documented adverse effect as nephrotoxicity. This study was designed to evaluate the nephroprotective role of Boerhaavia diffusa in cisplatin-induced acute kidney injury. Wistar rats (n = 6) were allocated into six gr...
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| Veröffentlicht in: | Regulatory toxicology and pharmacology 2016-11, Vol.81, p.341-352 |
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| creator | Karwasra, Ritu Kalra, Prerna Nag, T.C. Gupta, Y.K. Singh, Surender Panwar, Anuj |
| description | Cisplatin (Cis-diaminedichloroplatinum II) is a chemotherapeutic agent having well documented adverse effect as nephrotoxicity. This study was designed to evaluate the nephroprotective role of Boerhaavia diffusa in cisplatin-induced acute kidney injury. Wistar rats (n = 6) were allocated into six groups constituting normal control, cisplatin-induced, Boerhaavia diffusa root extract in doses 50, 100 and 200 mg/kg and Boerhaavia diffusa per se group, administered orally for a period of ten days. Intraperitoneal injection of cisplatin was administered on day 7, to all groups except normal control and Boerhaavia diffusa per se group. On day 10, cisplatin resulted in substantial nephrotoxicity in Wistar rats with significant (p |
| doi_str_mv | 10.1016/j.yrtph.2016.09.020 |
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[Display omitted]
•Tuberous roots of Boerhaavia diffusa provide nephroprotective effect in cisplatin induced acute kidney injury.•Boerhaavia diffusa could be a beneficial dietary supplement to attenuate cisplatin nephrotoxicity.•Safety profile of Boerhaavia diffusa was evaluated using acute and sub-acute toxicity studies.•No observed adverse effect level (NOAEL) of Boerhaavia diffusa was 1000 mg/kg.</description><identifier>ISSN: 0273-2300</identifier><identifier>EISSN: 1096-0295</identifier><identifier>DOI: 10.1016/j.yrtph.2016.09.020</identifier><identifier>PMID: 27667768</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Acute Kidney Injury - chemically induced ; Acute Kidney Injury - metabolism ; Acute Kidney Injury - pathology ; Acute toxicity study ; Administration, Oral ; Animals ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - toxicity ; Boerhaavia diffusa ; Cisplatin ; Cisplatin - administration & dosage ; Cisplatin - antagonists & inhibitors ; Cisplatin - toxicity ; Dose-Response Relationship, Drug ; Drug-Related Side Effects and Adverse Reactions ; Inflammation ; Injections, Intraperitoneal ; Male ; Nephrotoxicity ; Nyctaginaceae - chemistry ; Oxidative stress ; Plant Extracts - administration & dosage ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; Rats ; Rats, Wistar</subject><ispartof>Regulatory toxicology and pharmacology, 2016-11, Vol.81, p.341-352</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-a6ddfa2028bd2cadf7fab5bf4b3a5a286a586e3e57b6ab9b3cee534c27ed68783</citedby><cites>FETCH-LOGICAL-c359t-a6ddfa2028bd2cadf7fab5bf4b3a5a286a586e3e57b6ab9b3cee534c27ed68783</cites><orcidid>0000-0002-6962-0844</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0273230016302689$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27667768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karwasra, Ritu</creatorcontrib><creatorcontrib>Kalra, Prerna</creatorcontrib><creatorcontrib>Nag, T.C.</creatorcontrib><creatorcontrib>Gupta, Y.K.</creatorcontrib><creatorcontrib>Singh, Surender</creatorcontrib><creatorcontrib>Panwar, Anuj</creatorcontrib><title>Safety assessment and attenuation of cisplatin induced nephrotoxicity by tuberous roots of Boerhaavia diffusa</title><title>Regulatory toxicology and pharmacology</title><addtitle>Regul Toxicol Pharmacol</addtitle><description>Cisplatin (Cis-diaminedichloroplatinum II) is a chemotherapeutic agent having well documented adverse effect as nephrotoxicity. This study was designed to evaluate the nephroprotective role of Boerhaavia diffusa in cisplatin-induced acute kidney injury. Wistar rats (n = 6) were allocated into six groups constituting normal control, cisplatin-induced, Boerhaavia diffusa root extract in doses 50, 100 and 200 mg/kg and Boerhaavia diffusa per se group, administered orally for a period of ten days. Intraperitoneal injection of cisplatin was administered on day 7, to all groups except normal control and Boerhaavia diffusa per se group. On day 10, cisplatin resulted in substantial nephrotoxicity in Wistar rats with significant (p < 0.001) elevation in serum creatinine and blood urea nitrogen, decline in the concentrations of reduced glutathione and superoxide dismutase, elevation in TNF-α level in renal tissues. Boerhaavia diffusa at a dose of 200 mg/kg body weight significantly (p < 0.001) ameliorates increased in serum creatinine, blood urea nitrogen, oxidative stress and inflammatory markers. In parallel to this, it also exhibits antiapoptotic activity through the reduction of active caspase-3 expression in kidneys. Findings indicate that Boerhaavia diffusa is effective in mitigating cisplatin-induced nephrotoxicity and thus, for this the acute and sub-acute toxicity studies conducted to evaluate the safety profile of Boerhaavia diffusa. The no-observed adverse effect level (NOAEL) of tuberous roots of Boerhaavia diffusa root extract was 1000 mg/kg.
[Display omitted]
•Tuberous roots of Boerhaavia diffusa provide nephroprotective effect in cisplatin induced acute kidney injury.•Boerhaavia diffusa could be a beneficial dietary supplement to attenuate cisplatin nephrotoxicity.•Safety profile of Boerhaavia diffusa was evaluated using acute and sub-acute toxicity studies.•No observed adverse effect level (NOAEL) of Boerhaavia diffusa was 1000 mg/kg.</description><subject>Acute Kidney Injury - chemically induced</subject><subject>Acute Kidney Injury - metabolism</subject><subject>Acute Kidney Injury - pathology</subject><subject>Acute toxicity study</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Boerhaavia diffusa</subject><subject>Cisplatin</subject><subject>Cisplatin - administration & dosage</subject><subject>Cisplatin - antagonists & inhibitors</subject><subject>Cisplatin - toxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug-Related Side Effects and Adverse Reactions</subject><subject>Inflammation</subject><subject>Injections, Intraperitoneal</subject><subject>Male</subject><subject>Nephrotoxicity</subject><subject>Nyctaginaceae - chemistry</subject><subject>Oxidative stress</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0273-2300</issn><issn>1096-0295</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFv1DAQha0K1C6FX4CEfOSS4NhrJzlwgKqllSpxAM7W2B5rvdrEwXYq9t_jZQtHTqMnvTdv5iPkbcfajnXqw749prLsWl5Fy8aWcXZBNh0bVcP4KF-QDeO9aLhg7Iq8ynnPGOPD0F-SK94r1fdq2JDpG3gsRwo5Y84TzoXC7CiUgvMKJcSZRk9tyMuhqpmG2a0WHZ1x2aVY4q9gQ42bIy2rwRTXTFOMJZ9SnyOmHcBTAOqC92uG1-Slh0PGN8_zmvy4u_1-c988fv3ycPPpsbFCjqUB5ZwHXq81jltwvvdgpPFbI0ACHxTIQaFA2RsFZjTCIkqxtbxHp4Z-ENfk_XnvkuLPFXPRU8gWDweYsZ6ou0FIIbdi5NUqzlabYs4JvV5SmCAddcf0ibPe6z-c9YmzZqOunGvq3XPBaiZ0_zJ_wVbDx7MB65tPAZPONuBc0YWEtmgXw38LfgM-LpP_</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Karwasra, Ritu</creator><creator>Kalra, Prerna</creator><creator>Nag, T.C.</creator><creator>Gupta, Y.K.</creator><creator>Singh, Surender</creator><creator>Panwar, Anuj</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6962-0844</orcidid></search><sort><creationdate>201611</creationdate><title>Safety assessment and attenuation of cisplatin induced nephrotoxicity by tuberous roots of Boerhaavia diffusa</title><author>Karwasra, Ritu ; Kalra, Prerna ; Nag, T.C. ; Gupta, Y.K. ; Singh, Surender ; Panwar, Anuj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-a6ddfa2028bd2cadf7fab5bf4b3a5a286a586e3e57b6ab9b3cee534c27ed68783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute Kidney Injury - chemically induced</topic><topic>Acute Kidney Injury - metabolism</topic><topic>Acute Kidney Injury - pathology</topic><topic>Acute toxicity study</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Boerhaavia diffusa</topic><topic>Cisplatin</topic><topic>Cisplatin - administration & dosage</topic><topic>Cisplatin - antagonists & inhibitors</topic><topic>Cisplatin - toxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug-Related Side Effects and Adverse Reactions</topic><topic>Inflammation</topic><topic>Injections, Intraperitoneal</topic><topic>Male</topic><topic>Nephrotoxicity</topic><topic>Nyctaginaceae - chemistry</topic><topic>Oxidative stress</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karwasra, Ritu</creatorcontrib><creatorcontrib>Kalra, Prerna</creatorcontrib><creatorcontrib>Nag, T.C.</creatorcontrib><creatorcontrib>Gupta, Y.K.</creatorcontrib><creatorcontrib>Singh, Surender</creatorcontrib><creatorcontrib>Panwar, Anuj</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karwasra, Ritu</au><au>Kalra, Prerna</au><au>Nag, T.C.</au><au>Gupta, Y.K.</au><au>Singh, Surender</au><au>Panwar, Anuj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety assessment and attenuation of cisplatin induced nephrotoxicity by tuberous roots of Boerhaavia diffusa</atitle><jtitle>Regulatory toxicology and pharmacology</jtitle><addtitle>Regul Toxicol Pharmacol</addtitle><date>2016-11</date><risdate>2016</risdate><volume>81</volume><spage>341</spage><epage>352</epage><pages>341-352</pages><issn>0273-2300</issn><eissn>1096-0295</eissn><abstract>Cisplatin (Cis-diaminedichloroplatinum II) is a chemotherapeutic agent having well documented adverse effect as nephrotoxicity. This study was designed to evaluate the nephroprotective role of Boerhaavia diffusa in cisplatin-induced acute kidney injury. Wistar rats (n = 6) were allocated into six groups constituting normal control, cisplatin-induced, Boerhaavia diffusa root extract in doses 50, 100 and 200 mg/kg and Boerhaavia diffusa per se group, administered orally for a period of ten days. Intraperitoneal injection of cisplatin was administered on day 7, to all groups except normal control and Boerhaavia diffusa per se group. On day 10, cisplatin resulted in substantial nephrotoxicity in Wistar rats with significant (p < 0.001) elevation in serum creatinine and blood urea nitrogen, decline in the concentrations of reduced glutathione and superoxide dismutase, elevation in TNF-α level in renal tissues. Boerhaavia diffusa at a dose of 200 mg/kg body weight significantly (p < 0.001) ameliorates increased in serum creatinine, blood urea nitrogen, oxidative stress and inflammatory markers. In parallel to this, it also exhibits antiapoptotic activity through the reduction of active caspase-3 expression in kidneys. Findings indicate that Boerhaavia diffusa is effective in mitigating cisplatin-induced nephrotoxicity and thus, for this the acute and sub-acute toxicity studies conducted to evaluate the safety profile of Boerhaavia diffusa. The no-observed adverse effect level (NOAEL) of tuberous roots of Boerhaavia diffusa root extract was 1000 mg/kg.
[Display omitted]
•Tuberous roots of Boerhaavia diffusa provide nephroprotective effect in cisplatin induced acute kidney injury.•Boerhaavia diffusa could be a beneficial dietary supplement to attenuate cisplatin nephrotoxicity.•Safety profile of Boerhaavia diffusa was evaluated using acute and sub-acute toxicity studies.•No observed adverse effect level (NOAEL) of Boerhaavia diffusa was 1000 mg/kg.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>27667768</pmid><doi>10.1016/j.yrtph.2016.09.020</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6962-0844</orcidid></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acute Kidney Injury - chemically induced Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Acute toxicity study Administration, Oral Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - toxicity Boerhaavia diffusa Cisplatin Cisplatin - administration & dosage Cisplatin - antagonists & inhibitors Cisplatin - toxicity Dose-Response Relationship, Drug Drug-Related Side Effects and Adverse Reactions Inflammation Injections, Intraperitoneal Male Nephrotoxicity Nyctaginaceae - chemistry Oxidative stress Plant Extracts - administration & dosage Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Roots - chemistry Rats Rats, Wistar |
| title | Safety assessment and attenuation of cisplatin induced nephrotoxicity by tuberous roots of Boerhaavia diffusa |
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