mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function

Abstract Genetic- and diet-induced obesity and insulin resistance are associated with an increase in mechanistic target of rapamycin complex (mTORC) 1 activity in adipose tissue. We investigated herein the effects of pharmacological mTORC1 inhibition in the development of adipose tissue inflammation...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunobiology (1979) 2017-02, Vol.222 (2), p.261-271
Hauptverfasser:	Paschoal, Vivian A, Amano, Mariane T, Belchior, Thiago, Magdalon, Juliana, Chimin, Patricia, Andrade, Maynara L, Ortiz-Silva, Milene, Castro, Érique, Yamashita, Alex S, Rosa Neto, José Cesar, Câmara, Niels O, Festuccia, William T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue inflammation Advanced Basic Science Allergy and Immunology Animals Biomarkers Cytokines Cytokines - metabolism Glucose - metabolism Immunophenotyping Inflammation Mediators - metabolism Leukocytes - immunology Leukocytes - metabolism Leukocytes - pathology Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors Mice Mice, Inbred C57BL Mice, Obese mTOR Obesity Obesity - immunology Obesity - metabolism Obesity - pathology Panniculitis - immunology Panniculitis - metabolism Panniculitis - pathology Phenotype Rapamycin Sirolimus - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!