The Influence of Hemodialysis on T Regulatory Cells: A Meta-Analysis and Systematic Review
Aims: The study aimed to determine whether the available literature supports a positive or negative influence of dialysis on regulatory T-cells (Tregs). Methods: We performed a systematic search and a meta-analysis. Mean differences in Tregs number of chronic kidney disease stages G5 on dialysis pat...
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| Veröffentlicht in: | Blood purification 2016-01, Vol.42 (4), p.307-313 |
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| creator | Caprara, Carlotta Kinsey, Gilbert R. Corradi, Valentina Xin, Wenjun Ma, Jennie Z. Scalzotto, Elisa Martino, Francesca K. Okusa, Mark D. Nalesso, Federico Ferrari, Fiorenza Rosner, Mitchell Ronco, Claudio |
| description | Aims: The study aimed to determine whether the available literature supports a positive or negative influence of dialysis on regulatory T-cells (Tregs). Methods: We performed a systematic search and a meta-analysis. Mean differences in Tregs number of chronic kidney disease stages G5 on dialysis patients (CKD G5D) and healthy controls (HCs) were compared. Random effects model was applied. The software used was general package for meta-analysis (version 4.3-0, depends R (≥2.9.1)). Results: Five studies were included in the meta-analysis. The mean difference in percentage of Tregs on CD4+ T-cells between CKD G5D and HCs was not statistically different. Moreover, CKD GFR stages G5 not on dialysis (CKD G5) versus HC (p = 0.002; mean difference in Treg percentage was -2.47% in CKD G5 vs. HC) and CKD G5 versus CKD G5D (not significant). Conclusion: This meta-analysis demonstrates an association between the uremic state and lower Tregs, and supports the hypothesis that hemodialysis alter Tregs. Our findings highlight the need for new clinical studies. Video Journal Club ‘Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=449242. |
| doi_str_mv | 10.1159/000449242 |
| format | Article |
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Methods: We performed a systematic search and a meta-analysis. Mean differences in Tregs number of chronic kidney disease stages G5 on dialysis patients (CKD G5D) and healthy controls (HCs) were compared. Random effects model was applied. The software used was general package for meta-analysis (version 4.3-0, depends R (≥2.9.1)). Results: Five studies were included in the meta-analysis. The mean difference in percentage of Tregs on CD4+ T-cells between CKD G5D and HCs was not statistically different. Moreover, CKD GFR stages G5 not on dialysis (CKD G5) versus HC (p = 0.002; mean difference in Treg percentage was -2.47% in CKD G5 vs. HC) and CKD G5 versus CKD G5D (not significant). Conclusion: This meta-analysis demonstrates an association between the uremic state and lower Tregs, and supports the hypothesis that hemodialysis alter Tregs. Our findings highlight the need for new clinical studies. Video Journal Club ‘Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=449242.</description><identifier>ISSN: 0253-5068</identifier><identifier>EISSN: 1421-9735</identifier><identifier>DOI: 10.1159/000449242</identifier><identifier>PMID: 27694753</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Humans ; In-Depth Review ; Renal Dialysis ; Renal Insufficiency, Chronic</subject><ispartof>Blood purification, 2016-01, Vol.42 (4), p.307-313</ispartof><rights>2016 S. Karger AG, Basel</rights><rights>2016 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-49c5b5fb9f6ab93a86c740c97083602293dcf53fd5e9e184d64326bbd4332b893</citedby><orcidid>0000-0002-1167-2764 ; 0000-0002-6697-4065</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2422,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27694753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caprara, Carlotta</creatorcontrib><creatorcontrib>Kinsey, Gilbert R.</creatorcontrib><creatorcontrib>Corradi, Valentina</creatorcontrib><creatorcontrib>Xin, Wenjun</creatorcontrib><creatorcontrib>Ma, Jennie Z.</creatorcontrib><creatorcontrib>Scalzotto, Elisa</creatorcontrib><creatorcontrib>Martino, Francesca K.</creatorcontrib><creatorcontrib>Okusa, Mark D.</creatorcontrib><creatorcontrib>Nalesso, Federico</creatorcontrib><creatorcontrib>Ferrari, Fiorenza</creatorcontrib><creatorcontrib>Rosner, Mitchell</creatorcontrib><creatorcontrib>Ronco, Claudio</creatorcontrib><title>The Influence of Hemodialysis on T Regulatory Cells: A Meta-Analysis and Systematic Review</title><title>Blood purification</title><addtitle>Blood Purif</addtitle><description>Aims: The study aimed to determine whether the available literature supports a positive or negative influence of dialysis on regulatory T-cells (Tregs). Methods: We performed a systematic search and a meta-analysis. Mean differences in Tregs number of chronic kidney disease stages G5 on dialysis patients (CKD G5D) and healthy controls (HCs) were compared. Random effects model was applied. The software used was general package for meta-analysis (version 4.3-0, depends R (≥2.9.1)). Results: Five studies were included in the meta-analysis. The mean difference in percentage of Tregs on CD4+ T-cells between CKD G5D and HCs was not statistically different. Moreover, CKD GFR stages G5 not on dialysis (CKD G5) versus HC (p = 0.002; mean difference in Treg percentage was -2.47% in CKD G5 vs. HC) and CKD G5 versus CKD G5D (not significant). Conclusion: This meta-analysis demonstrates an association between the uremic state and lower Tregs, and supports the hypothesis that hemodialysis alter Tregs. Our findings highlight the need for new clinical studies. 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| subjects | Humans In-Depth Review Renal Dialysis Renal Insufficiency, Chronic |
| title | The Influence of Hemodialysis on T Regulatory Cells: A Meta-Analysis and Systematic Review |
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