Effects of ZD0947, a novel and potent ATP-sensitive K+ channel opener, on smooth muscle-type ATP-sensitive K+ channels

The effects of ZD0947, a novel ATP-sensitive K+ channel (KATP channel) opener, on the activity of reconstituted KATP channels were investigated using cell-attached recordings. KATP channels were studied in HEK 293 cells by co-expression of inwardly rectifying-6 family K+ channel subunits (Kir6.x: Ki...

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Veröffentlicht in:	European journal of pharmacology 2016-11, Vol.791, p.773-779
Hauptverfasser:	Mori, Keisuke, Yamashita, Yoshio, Teramoto, Noriyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-sensitive K+ channels Dihydropyridines - pharmacology Dose-Response Relationship, Drug HEK293 Cells Humans Ion Channel Gating - drug effects K+ channel opener KATP Channels - chemistry KATP Channels - metabolism Muscle, Smooth - metabolism Pinacidil - pharmacology Smooth muscle Sulfonylurea Receptors - metabolism ZD0947
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