Investigating mixing and segregation using discrete element modelling (DEM) in the Freeman FT4 rheometer
[Display omitted] Mixing and segregation in a Freeman FT4 powder rheometer, using binary mixtures with varied particle size ratio and volume fraction, were studied using the Discrete Element Method (DEM). As the blade moves within the particle bed, size induced segregations can occur via a sifting m...
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Veröffentlicht in: | International journal of pharmaceutics 2016-11, Vol.513 (1-2), p.38-48 |
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container_title | International journal of pharmaceutics |
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creator | Yan, Zilin Wilkinson, Sam K. Stitt, Edmund H. Marigo, Michele |
description | [Display omitted]
Mixing and segregation in a Freeman FT4 powder rheometer, using binary mixtures with varied particle size ratio and volume fraction, were studied using the Discrete Element Method (DEM). As the blade moves within the particle bed, size induced segregations can occur via a sifting mechanism. A larger particle size ratio and/or a larger volume fraction of large particles lead to a quicker segregation process. A higher particle velocity magnitude can promote the segregation process and the rate for the segregation index increases in the radial direction: from the centre towards the outer layer. In the current DEM simulations, it is shown that the change in flow energy associated with segregation and mixing depends on the choice of frictional input parameters. FT4 is proposed as a potential tool to compare and rank the segregation tendency for particulate materials with distinct differences in flow energy of each component. This is achieved by measuring the flow energy gradient after a number of test cycles for mixing powders with different flow properties. Employing the FT4 dynamic powder characterisation can be advantageous to establish blending performances in an industrial context. |
doi_str_mv | 10.1016/j.ijpharm.2016.08.065 |
format | Article |
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Mixing and segregation in a Freeman FT4 powder rheometer, using binary mixtures with varied particle size ratio and volume fraction, were studied using the Discrete Element Method (DEM). As the blade moves within the particle bed, size induced segregations can occur via a sifting mechanism. A larger particle size ratio and/or a larger volume fraction of large particles lead to a quicker segregation process. A higher particle velocity magnitude can promote the segregation process and the rate for the segregation index increases in the radial direction: from the centre towards the outer layer. In the current DEM simulations, it is shown that the change in flow energy associated with segregation and mixing depends on the choice of frictional input parameters. FT4 is proposed as a potential tool to compare and rank the segregation tendency for particulate materials with distinct differences in flow energy of each component. This is achieved by measuring the flow energy gradient after a number of test cycles for mixing powders with different flow properties. Employing the FT4 dynamic powder characterisation can be advantageous to establish blending performances in an industrial context.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2016.08.065</identifier><identifier>PMID: 27596114</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Chemistry, Pharmaceutical - instrumentation ; Chemistry, Pharmaceutical - methods ; Dem ; Discrete element method ; Freeman FT4 rheometer ; Input parameters ; Models, Theoretical ; Particle Size ; Powder mixing ; Powder segregation ; Powders ; Rheology ; Technology, Pharmaceutical - instrumentation ; Technology, Pharmaceutical - methods</subject><ispartof>International journal of pharmaceutics, 2016-11, Vol.513 (1-2), p.38-48</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-ab5b8ae0c54f00d1e5ea390a49a885d49515391cca027f0522597b37a006add23</citedby><cites>FETCH-LOGICAL-c365t-ab5b8ae0c54f00d1e5ea390a49a885d49515391cca027f0522597b37a006add23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517316308201$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27596114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Zilin</creatorcontrib><creatorcontrib>Wilkinson, Sam K.</creatorcontrib><creatorcontrib>Stitt, Edmund H.</creatorcontrib><creatorcontrib>Marigo, Michele</creatorcontrib><title>Investigating mixing and segregation using discrete element modelling (DEM) in the Freeman FT4 rheometer</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
Mixing and segregation in a Freeman FT4 powder rheometer, using binary mixtures with varied particle size ratio and volume fraction, were studied using the Discrete Element Method (DEM). As the blade moves within the particle bed, size induced segregations can occur via a sifting mechanism. A larger particle size ratio and/or a larger volume fraction of large particles lead to a quicker segregation process. A higher particle velocity magnitude can promote the segregation process and the rate for the segregation index increases in the radial direction: from the centre towards the outer layer. In the current DEM simulations, it is shown that the change in flow energy associated with segregation and mixing depends on the choice of frictional input parameters. FT4 is proposed as a potential tool to compare and rank the segregation tendency for particulate materials with distinct differences in flow energy of each component. This is achieved by measuring the flow energy gradient after a number of test cycles for mixing powders with different flow properties. Employing the FT4 dynamic powder characterisation can be advantageous to establish blending performances in an industrial context.</description><subject>Chemistry, Pharmaceutical - instrumentation</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Dem</subject><subject>Discrete element method</subject><subject>Freeman FT4 rheometer</subject><subject>Input parameters</subject><subject>Models, Theoretical</subject><subject>Particle Size</subject><subject>Powder mixing</subject><subject>Powder segregation</subject><subject>Powders</subject><subject>Rheology</subject><subject>Technology, Pharmaceutical - instrumentation</subject><subject>Technology, Pharmaceutical - methods</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PAyEQhonRaP34CRqOeth1WJb9OBlTrZpovOiZUJi2NIWtsDX672XT6tXThJn3ZeZ9CDlnkDNg1fUyt8v1QgWXF-mZQ5NDJfbIiDU1z3hZV_tkBLxuMsFqfkSOY1wCQFUwfkiOilq0FWPliCye_CfG3s5Vb_2cOvs1FOUNjTgPOLQ7Tzdx6BobdcAeKa7Qoe-p6wyuVsPo8u7-5YpaT_sF0klAdMrTyVtJwwI7lzzhlBzM1Cri2a6ekPfJ_dv4MXt-fXga3z5nmleiz9RUTBuFoEU5AzAMBSregipb1TTClK1ggrdMawVFPQNRFKKtp7xWKZsypuAn5HL77zp0H5sUTbp0djpTeew2UbKGCy6gYm2Siq1Uhy7GgDO5Dtap8C0ZyAGyXModZDlAltDIBDn5LnYrNlOH5s_1SzUJbrYCTEE_LQYZtUWv0diAupems_-s-AFzL5Bz</recordid><startdate>20161120</startdate><enddate>20161120</enddate><creator>Yan, Zilin</creator><creator>Wilkinson, Sam K.</creator><creator>Stitt, Edmund H.</creator><creator>Marigo, Michele</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161120</creationdate><title>Investigating mixing and segregation using discrete element modelling (DEM) in the Freeman FT4 rheometer</title><author>Yan, Zilin ; Wilkinson, Sam K. ; Stitt, Edmund H. ; Marigo, Michele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-ab5b8ae0c54f00d1e5ea390a49a885d49515391cca027f0522597b37a006add23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Chemistry, Pharmaceutical - instrumentation</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Dem</topic><topic>Discrete element method</topic><topic>Freeman FT4 rheometer</topic><topic>Input parameters</topic><topic>Models, Theoretical</topic><topic>Particle Size</topic><topic>Powder mixing</topic><topic>Powder segregation</topic><topic>Powders</topic><topic>Rheology</topic><topic>Technology, Pharmaceutical - instrumentation</topic><topic>Technology, Pharmaceutical - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Zilin</creatorcontrib><creatorcontrib>Wilkinson, Sam K.</creatorcontrib><creatorcontrib>Stitt, Edmund H.</creatorcontrib><creatorcontrib>Marigo, Michele</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Zilin</au><au>Wilkinson, Sam K.</au><au>Stitt, Edmund H.</au><au>Marigo, Michele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigating mixing and segregation using discrete element modelling (DEM) in the Freeman FT4 rheometer</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2016-11-20</date><risdate>2016</risdate><volume>513</volume><issue>1-2</issue><spage>38</spage><epage>48</epage><pages>38-48</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
Mixing and segregation in a Freeman FT4 powder rheometer, using binary mixtures with varied particle size ratio and volume fraction, were studied using the Discrete Element Method (DEM). As the blade moves within the particle bed, size induced segregations can occur via a sifting mechanism. A larger particle size ratio and/or a larger volume fraction of large particles lead to a quicker segregation process. A higher particle velocity magnitude can promote the segregation process and the rate for the segregation index increases in the radial direction: from the centre towards the outer layer. In the current DEM simulations, it is shown that the change in flow energy associated with segregation and mixing depends on the choice of frictional input parameters. FT4 is proposed as a potential tool to compare and rank the segregation tendency for particulate materials with distinct differences in flow energy of each component. This is achieved by measuring the flow energy gradient after a number of test cycles for mixing powders with different flow properties. Employing the FT4 dynamic powder characterisation can be advantageous to establish blending performances in an industrial context.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27596114</pmid><doi>10.1016/j.ijpharm.2016.08.065</doi><tpages>11</tpages></addata></record> |
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subjects | Chemistry, Pharmaceutical - instrumentation Chemistry, Pharmaceutical - methods Dem Discrete element method Freeman FT4 rheometer Input parameters Models, Theoretical Particle Size Powder mixing Powder segregation Powders Rheology Technology, Pharmaceutical - instrumentation Technology, Pharmaceutical - methods |
title | Investigating mixing and segregation using discrete element modelling (DEM) in the Freeman FT4 rheometer |
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