Integration of superoxide formation and cristae morphology for mitochondrial redox signaling

[Display omitted] •Cristae shape is governed by ATP-synthase dimers, MICOS, and OPA1 isoforms.•ATP-synthase dimers decrease in the inflated intracristal space, diminishing ΔpH.•Diffusion of intracristal signaling ROS species is controlled by crista crista junctions.•Opening of crista junctions allow...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2016-11, Vol.80, p.31-50
Hauptverfasser:	Plecitá-Hlavatá, Lydie, Ježek, Petr
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - biosynthesis Animals ATP-synthase dimers Humans MICOS Mitochondria - metabolism Mitochondrial cristae morphology Mitochondrial Membranes - metabolism OPA1 Redox signaling Signal Transduction Superoxides - metabolism
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