Imaging the Transformation of Ipsilateral Internal Capsule Following Focal Cerebral Ischemia in Rat by Diffusion Kurtosis Imaging
Background The purpose of our study is to explore the relationship between recovery of neural function and transformation of the internal capsule (IC) after transient middle cerebral artery occlusion (MCAO) by using diffusion kurtosis imaging (DKI). Methods Six male adult Sprague-Dawley rats impleme...
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| Veröffentlicht in: | Journal of stroke and cerebrovascular diseases 2017-01, Vol.26 (1), p.42-48 |
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| creator | Zhang, Xiao-xue Yin, Le-kang Hao, Xiao-zhu Tian, Jia-qi Li, Chan-chan Feng, Xiao-yuan Yang, Yan-mei |
| description | Background The purpose of our study is to explore the relationship between recovery of neural function and transformation of the internal capsule (IC) after transient middle cerebral artery occlusion (MCAO) by using diffusion kurtosis imaging (DKI). Methods Six male adult Sprague-Dawley rats implemented with transient MCAO were used in this study. Sensorimotor function was assessed according to repetitive behavioral testing on day 1, 3, 7, 14, and 28 after cerebral ischemia. Metrics of DKI were acquired, and the time course of the region-to-normal ratio was evaluated in IC. Results After cerebral ischemia, relative fractional anisotropy in IC decreased on day 3 ( P |
| doi_str_mv | 10.1016/j.jstrokecerebrovasdis.2016.08.026 |
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Methods Six male adult Sprague-Dawley rats implemented with transient MCAO were used in this study. Sensorimotor function was assessed according to repetitive behavioral testing on day 1, 3, 7, 14, and 28 after cerebral ischemia. Metrics of DKI were acquired, and the time course of the region-to-normal ratio was evaluated in IC. Results After cerebral ischemia, relative fractional anisotropy in IC decreased on day 3 ( P < .01). Relative mean diffusivity (rMD) increased on day 28 ( P < .05). Relative mean diffusional kurtosis (rMK) increased on day 3 ( P < .01) and decreased on day 7 ( P < .05). Relative axial diffusional kurtosis (rKa) increased on day 3 ( P < .01) and declined on day 7 ( P < .05). Relative radial diffusional kurtosis (rKr) was reduced on day 7 ( P < .05). Changes in rMK were larger than changes in rMD on day 3 ( P < .05). The factor of rKa and rKr revealed marked difference on day 7 ( P < .05) and day 14 ( P < .05). Neurological function score showed that rats exhibited functional recovery from day 7 ( P < .01) post stroke. Conclusions This longitudinal multiparametric magnetic resonance imaging study suggested that K metrics offers information complimentary to conventional diffusion metrics and revealed the procedure during the structural modification in the ipsilateral IC following focal cerebral ischemia. After transient MCAO, the neural transformation occurred in a time-dependent procedure.]]></description><identifier>ISSN: 1052-3057</identifier><identifier>EISSN: 1532-8511</identifier><identifier>DOI: 10.1016/j.jstrokecerebrovasdis.2016.08.026</identifier><identifier>PMID: 27693403</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Analysis of Variance ; Animals ; Anisotropy ; Cardiovascular ; diffusion kurtosis imaging ; Diffusion Magnetic Resonance Imaging - methods ; Disease Models, Animal ; Functional Laterality - physiology ; functional recovery ; Image Processing, Computer-Assisted ; Infarction, Middle Cerebral Artery - complications ; Infarction, Middle Cerebral Artery - diagnostic imaging ; internal capsule ; Internal Capsule - diagnostic imaging ; K metrics ; magnetic resonance imaging ; Male ; Nervous System Diseases - diagnostic imaging ; Nervous System Diseases - etiology ; Neurology ; Normal Distribution ; Rats ; Rats, Sprague-Dawley ; Stroke ; Time Factors</subject><ispartof>Journal of stroke and cerebrovascular diseases, 2017-01, Vol.26 (1), p.42-48</ispartof><rights>National Stroke Association</rights><rights>2017 National Stroke Association</rights><rights>Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-d18d9478c8721c3ab797ccde092844954ab4bff687959029c311324d4e9c329c3</citedby><cites>FETCH-LOGICAL-c459t-d18d9478c8721c3ab797ccde092844954ab4bff687959029c311324d4e9c329c3</cites><orcidid>0000-0001-7635-863X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1052305716302981$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27693403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Xiao-xue</creatorcontrib><creatorcontrib>Yin, Le-kang</creatorcontrib><creatorcontrib>Hao, Xiao-zhu</creatorcontrib><creatorcontrib>Tian, Jia-qi</creatorcontrib><creatorcontrib>Li, Chan-chan</creatorcontrib><creatorcontrib>Feng, Xiao-yuan</creatorcontrib><creatorcontrib>Yang, Yan-mei</creatorcontrib><title>Imaging the Transformation of Ipsilateral Internal Capsule Following Focal Cerebral Ischemia in Rat by Diffusion Kurtosis Imaging</title><title>Journal of stroke and cerebrovascular diseases</title><addtitle>J Stroke Cerebrovasc Dis</addtitle><description><![CDATA[Background The purpose of our study is to explore the relationship between recovery of neural function and transformation of the internal capsule (IC) after transient middle cerebral artery occlusion (MCAO) by using diffusion kurtosis imaging (DKI). Methods Six male adult Sprague-Dawley rats implemented with transient MCAO were used in this study. Sensorimotor function was assessed according to repetitive behavioral testing on day 1, 3, 7, 14, and 28 after cerebral ischemia. Metrics of DKI were acquired, and the time course of the region-to-normal ratio was evaluated in IC. Results After cerebral ischemia, relative fractional anisotropy in IC decreased on day 3 ( P < .01). Relative mean diffusivity (rMD) increased on day 28 ( P < .05). Relative mean diffusional kurtosis (rMK) increased on day 3 ( P < .01) and decreased on day 7 ( P < .05). Relative axial diffusional kurtosis (rKa) increased on day 3 ( P < .01) and declined on day 7 ( P < .05). Relative radial diffusional kurtosis (rKr) was reduced on day 7 ( P < .05). Changes in rMK were larger than changes in rMD on day 3 ( P < .05). The factor of rKa and rKr revealed marked difference on day 7 ( P < .05) and day 14 ( P < .05). Neurological function score showed that rats exhibited functional recovery from day 7 ( P < .01) post stroke. Conclusions This longitudinal multiparametric magnetic resonance imaging study suggested that K metrics offers information complimentary to conventional diffusion metrics and revealed the procedure during the structural modification in the ipsilateral IC following focal cerebral ischemia. After transient MCAO, the neural transformation occurred in a time-dependent procedure.]]></description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Anisotropy</subject><subject>Cardiovascular</subject><subject>diffusion kurtosis imaging</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Disease Models, Animal</subject><subject>Functional Laterality - physiology</subject><subject>functional recovery</subject><subject>Image Processing, Computer-Assisted</subject><subject>Infarction, Middle Cerebral Artery - complications</subject><subject>Infarction, Middle Cerebral Artery - diagnostic imaging</subject><subject>internal capsule</subject><subject>Internal Capsule - diagnostic imaging</subject><subject>K metrics</subject><subject>magnetic resonance imaging</subject><subject>Male</subject><subject>Nervous System Diseases - diagnostic imaging</subject><subject>Nervous System Diseases - etiology</subject><subject>Neurology</subject><subject>Normal Distribution</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Stroke</subject><subject>Time Factors</subject><issn>1052-3057</issn><issn>1532-8511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUsFu1DAQjRCIlsIvIB8RUlI7thPnggRbFlashATlbDnOpPU2iRdPUrRH_hyb3XJAXDjNePz8nmfeZNlrRgtGWXW5K3Y4B38HFgK0wd8b7BwWZbwrqCpoWT3KzpnkZa4kY49jTmWZcyrrs-wZ4o5SxqSST7Ozsq4aLig_z35uRnPjphsy3wK5DmbC3ofRzM5PxPdks0c3mBmCGchminGKycrscRmArP0w-B_p8drbVP_9rYREewujM8RN5IuZSXsgV67vF0ysn5Ywe3RITsrPsye9GRBenOJF9m39_nr1Md9-_rBZvd3mVshmzjumukbUyqq6ZJabtm5qazugTamEaKQwrWj7vlJ1IxtaNpYzxkvRCYhpOl5kr468--C_L4CzHh1aGAYzgV9QM8UlFw3jIkLfHaE2eMQAvd4HN5pw0IzqZIXe6X9ZoZMVmiodrYgkL096SztC94fiYfYRsD0CIHZ97yBotA4mC50LYGfdefd_em_-orODm1w05g4OgDu_JPNinxpLTfXXtBxpN1jF47gU478AEi2_GA</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Zhang, Xiao-xue</creator><creator>Yin, Le-kang</creator><creator>Hao, Xiao-zhu</creator><creator>Tian, Jia-qi</creator><creator>Li, Chan-chan</creator><creator>Feng, Xiao-yuan</creator><creator>Yang, Yan-mei</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7635-863X</orcidid></search><sort><creationdate>20170101</creationdate><title>Imaging the Transformation of Ipsilateral Internal Capsule Following Focal Cerebral Ischemia in Rat by Diffusion Kurtosis Imaging</title><author>Zhang, Xiao-xue ; Yin, Le-kang ; Hao, Xiao-zhu ; Tian, Jia-qi ; Li, Chan-chan ; Feng, Xiao-yuan ; Yang, Yan-mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-d18d9478c8721c3ab797ccde092844954ab4bff687959029c311324d4e9c329c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Anisotropy</topic><topic>Cardiovascular</topic><topic>diffusion kurtosis imaging</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Disease Models, Animal</topic><topic>Functional Laterality - physiology</topic><topic>functional recovery</topic><topic>Image Processing, Computer-Assisted</topic><topic>Infarction, Middle Cerebral Artery - complications</topic><topic>Infarction, Middle Cerebral Artery - diagnostic imaging</topic><topic>internal capsule</topic><topic>Internal Capsule - diagnostic imaging</topic><topic>K metrics</topic><topic>magnetic resonance imaging</topic><topic>Male</topic><topic>Nervous System Diseases - diagnostic imaging</topic><topic>Nervous System Diseases - etiology</topic><topic>Neurology</topic><topic>Normal Distribution</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Stroke</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xiao-xue</creatorcontrib><creatorcontrib>Yin, Le-kang</creatorcontrib><creatorcontrib>Hao, Xiao-zhu</creatorcontrib><creatorcontrib>Tian, Jia-qi</creatorcontrib><creatorcontrib>Li, Chan-chan</creatorcontrib><creatorcontrib>Feng, Xiao-yuan</creatorcontrib><creatorcontrib>Yang, Yan-mei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of stroke and cerebrovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xiao-xue</au><au>Yin, Le-kang</au><au>Hao, Xiao-zhu</au><au>Tian, Jia-qi</au><au>Li, Chan-chan</au><au>Feng, Xiao-yuan</au><au>Yang, Yan-mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imaging the Transformation of Ipsilateral Internal Capsule Following Focal Cerebral Ischemia in Rat by Diffusion Kurtosis Imaging</atitle><jtitle>Journal of stroke and cerebrovascular diseases</jtitle><addtitle>J Stroke Cerebrovasc Dis</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>26</volume><issue>1</issue><spage>42</spage><epage>48</epage><pages>42-48</pages><issn>1052-3057</issn><eissn>1532-8511</eissn><abstract><![CDATA[Background The purpose of our study is to explore the relationship between recovery of neural function and transformation of the internal capsule (IC) after transient middle cerebral artery occlusion (MCAO) by using diffusion kurtosis imaging (DKI). Methods Six male adult Sprague-Dawley rats implemented with transient MCAO were used in this study. Sensorimotor function was assessed according to repetitive behavioral testing on day 1, 3, 7, 14, and 28 after cerebral ischemia. Metrics of DKI were acquired, and the time course of the region-to-normal ratio was evaluated in IC. Results After cerebral ischemia, relative fractional anisotropy in IC decreased on day 3 ( P < .01). Relative mean diffusivity (rMD) increased on day 28 ( P < .05). Relative mean diffusional kurtosis (rMK) increased on day 3 ( P < .01) and decreased on day 7 ( P < .05). Relative axial diffusional kurtosis (rKa) increased on day 3 ( P < .01) and declined on day 7 ( P < .05). Relative radial diffusional kurtosis (rKr) was reduced on day 7 ( P < .05). Changes in rMK were larger than changes in rMD on day 3 ( P < .05). The factor of rKa and rKr revealed marked difference on day 7 ( P < .05) and day 14 ( P < .05). Neurological function score showed that rats exhibited functional recovery from day 7 ( P < .01) post stroke. Conclusions This longitudinal multiparametric magnetic resonance imaging study suggested that K metrics offers information complimentary to conventional diffusion metrics and revealed the procedure during the structural modification in the ipsilateral IC following focal cerebral ischemia. After transient MCAO, the neural transformation occurred in a time-dependent procedure.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27693403</pmid><doi>10.1016/j.jstrokecerebrovasdis.2016.08.026</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7635-863X</orcidid></addata></record> |
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| subjects | Analysis of Variance Animals Anisotropy Cardiovascular diffusion kurtosis imaging Diffusion Magnetic Resonance Imaging - methods Disease Models, Animal Functional Laterality - physiology functional recovery Image Processing, Computer-Assisted Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - diagnostic imaging internal capsule Internal Capsule - diagnostic imaging K metrics magnetic resonance imaging Male Nervous System Diseases - diagnostic imaging Nervous System Diseases - etiology Neurology Normal Distribution Rats Rats, Sprague-Dawley Stroke Time Factors |
| title | Imaging the Transformation of Ipsilateral Internal Capsule Following Focal Cerebral Ischemia in Rat by Diffusion Kurtosis Imaging |
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