Novel alginate-stabilized doxorubicin-loaded nanodroplets for ultrasounic theranosis of breast cancer
[Display omitted] Perfluorocarbon nanoemulsions are a new class of multifunctional stimuli-responsive nanocarriers which combine the properties of passive-targeted drug carriers, ultrasound imaging contrast agents, and ultrasound-responsive drug delivery systems. Doxorubicin-loaded alginate stabiliz...
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| Veröffentlicht in: | International journal of biological macromolecules 2016-12, Vol.93 (Pt A), p.512-519 |
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| container_issue | Pt A |
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| container_title | International journal of biological macromolecules |
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| creator | Baghbani, Fatemeh Moztarzadeh, Fathollah Mohandesi, Jamshid Aghazadeh Yazdian, Fatemeh Mokhtari-Dizaji, Manijhe |
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Perfluorocarbon nanoemulsions are a new class of multifunctional stimuli-responsive nanocarriers which combine the properties of passive-targeted drug carriers, ultrasound imaging contrast agents, and ultrasound-responsive drug delivery systems. Doxorubicin-loaded alginate stabilized perflourohexane (PFH) nanodroplets were synthesized via nanoemulsion preparation method and their ultrasound responsivity, imaging, and therapeutic properties were studied. Doxorubicin was loaded into the nanodroplets (39.2nm) with encapsulation efficiency of 92.2%. In vitro release profile of doxorubicin from nanodroplets was an apparently biphasic release process and 12.6% of drug released from nanodroplets after 24h incubation in PBS, pH=7.4. Sonication with 28kHz therapeutic ultrasound for 10min triggered droplet-to-bubble transition in PFH nanodroplets which resulted in the release of 85.95% of doxorubicin from nanodroplets. Microbubbles formed by acoustic vaporization of the nanodroplets underwent inertial cavitation.
In the breast cancer mice models, ultrasound-mediated therapy with doxorubicin-loaded PFH nanodroplets showed excellent anti-cancer effects characterized by tumor regression. Complete tumor regression was observed for the group in which doxorubicin-loaded nanodroplets were combined with ultrasound, whereas the tumor growth inhibition of doxorubicin −loaded nanodroplets was 89.6%. These multifunctional nanodroplets, with excellent therapeutic and ultrasound properties, could be promising drug delivery systems for chemotherapeutic application. |
| doi_str_mv | 10.1016/j.ijbiomac.2016.09.008 |
| format | Article |
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Perfluorocarbon nanoemulsions are a new class of multifunctional stimuli-responsive nanocarriers which combine the properties of passive-targeted drug carriers, ultrasound imaging contrast agents, and ultrasound-responsive drug delivery systems. Doxorubicin-loaded alginate stabilized perflourohexane (PFH) nanodroplets were synthesized via nanoemulsion preparation method and their ultrasound responsivity, imaging, and therapeutic properties were studied. Doxorubicin was loaded into the nanodroplets (39.2nm) with encapsulation efficiency of 92.2%. In vitro release profile of doxorubicin from nanodroplets was an apparently biphasic release process and 12.6% of drug released from nanodroplets after 24h incubation in PBS, pH=7.4. Sonication with 28kHz therapeutic ultrasound for 10min triggered droplet-to-bubble transition in PFH nanodroplets which resulted in the release of 85.95% of doxorubicin from nanodroplets. Microbubbles formed by acoustic vaporization of the nanodroplets underwent inertial cavitation.
In the breast cancer mice models, ultrasound-mediated therapy with doxorubicin-loaded PFH nanodroplets showed excellent anti-cancer effects characterized by tumor regression. Complete tumor regression was observed for the group in which doxorubicin-loaded nanodroplets were combined with ultrasound, whereas the tumor growth inhibition of doxorubicin −loaded nanodroplets was 89.6%. These multifunctional nanodroplets, with excellent therapeutic and ultrasound properties, could be promising drug delivery systems for chemotherapeutic application.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2016.09.008</identifier><identifier>PMID: 27601134</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alginate-stabilized nanodroplets ; Alginates - chemistry ; Alginates - pharmacology ; Animals ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cell Line, Tumor ; Doxorubicin - chemistry ; Doxorubicin - pharmacology ; Drug Carriers - chemistry ; Drug Carriers - pharmacology ; Female ; Glucuronic Acid - chemistry ; Glucuronic Acid - pharmacology ; Hexuronic Acids - chemistry ; Hexuronic Acids - pharmacology ; Humans ; Mice ; Mice, Inbred BALB C ; Nanoparticles - chemistry ; Theranostic Nanomedicine - methods ; Ultrasound ; Xenograft Model Antitumor Assays</subject><ispartof>International journal of biological macromolecules, 2016-12, Vol.93 (Pt A), p.512-519</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-e0e309d9aad449c6284e5d32b66b84b0929d8389e030e3f3c7e1d5213aed3e003</citedby><cites>FETCH-LOGICAL-c368t-e0e309d9aad449c6284e5d32b66b84b0929d8389e030e3f3c7e1d5213aed3e003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2016.09.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27601134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baghbani, Fatemeh</creatorcontrib><creatorcontrib>Moztarzadeh, Fathollah</creatorcontrib><creatorcontrib>Mohandesi, Jamshid Aghazadeh</creatorcontrib><creatorcontrib>Yazdian, Fatemeh</creatorcontrib><creatorcontrib>Mokhtari-Dizaji, Manijhe</creatorcontrib><title>Novel alginate-stabilized doxorubicin-loaded nanodroplets for ultrasounic theranosis of breast cancer</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>[Display omitted]
Perfluorocarbon nanoemulsions are a new class of multifunctional stimuli-responsive nanocarriers which combine the properties of passive-targeted drug carriers, ultrasound imaging contrast agents, and ultrasound-responsive drug delivery systems. Doxorubicin-loaded alginate stabilized perflourohexane (PFH) nanodroplets were synthesized via nanoemulsion preparation method and their ultrasound responsivity, imaging, and therapeutic properties were studied. Doxorubicin was loaded into the nanodroplets (39.2nm) with encapsulation efficiency of 92.2%. In vitro release profile of doxorubicin from nanodroplets was an apparently biphasic release process and 12.6% of drug released from nanodroplets after 24h incubation in PBS, pH=7.4. Sonication with 28kHz therapeutic ultrasound for 10min triggered droplet-to-bubble transition in PFH nanodroplets which resulted in the release of 85.95% of doxorubicin from nanodroplets. Microbubbles formed by acoustic vaporization of the nanodroplets underwent inertial cavitation.
In the breast cancer mice models, ultrasound-mediated therapy with doxorubicin-loaded PFH nanodroplets showed excellent anti-cancer effects characterized by tumor regression. Complete tumor regression was observed for the group in which doxorubicin-loaded nanodroplets were combined with ultrasound, whereas the tumor growth inhibition of doxorubicin −loaded nanodroplets was 89.6%. These multifunctional nanodroplets, with excellent therapeutic and ultrasound properties, could be promising drug delivery systems for chemotherapeutic application.</description><subject>Alginate-stabilized nanodroplets</subject><subject>Alginates - chemistry</subject><subject>Alginates - pharmacology</subject><subject>Animals</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell Line, Tumor</subject><subject>Doxorubicin - chemistry</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - pharmacology</subject><subject>Female</subject><subject>Glucuronic Acid - chemistry</subject><subject>Glucuronic Acid - pharmacology</subject><subject>Hexuronic Acids - chemistry</subject><subject>Hexuronic Acids - pharmacology</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nanoparticles - chemistry</subject><subject>Theranostic Nanomedicine - methods</subject><subject>Ultrasound</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PwzAMQCMEgjH4C6hHLi1O03XJDYT4kia4wDlKExcyZc1IUgT8ejJtcOVk2X625UfIGYWKAm0vlpVddtavlK7qnFcgKgC-RyaUz0UJAGyfTIA2tOSUwRE5jnGZq-2M8kNyVM9boJQ1E4KP_gNdodyrHVTCMibVWWe_0RTGf_owdlbboXRemVwa1OBN8GuHKRa9D8XoUlDRj4PVRXrDkPvRxsL3RRdQxVRoNWgMJ-SgVy7i6S5OycvtzfP1fbl4unu4vlqUmrU8lQjIQBihlGkaoduaNzgzrO7atuNNB6IWhjMuEFgme6bnSM2spkyhYZh_npLz7d518O8jxiRXNmp0Tg3oxygpZzPW8DkVGW23qA4-xoC9XAe7UuFLUpAbxXIpfxXLjWIJQmbFefBsd2PsVmj-xn6dZuByC2D-9MNikFFbzBqMDaiTNN7-d-MH4zmSbw</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Baghbani, Fatemeh</creator><creator>Moztarzadeh, Fathollah</creator><creator>Mohandesi, Jamshid Aghazadeh</creator><creator>Yazdian, Fatemeh</creator><creator>Mokhtari-Dizaji, Manijhe</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201612</creationdate><title>Novel alginate-stabilized doxorubicin-loaded nanodroplets for ultrasounic theranosis of breast cancer</title><author>Baghbani, Fatemeh ; Moztarzadeh, Fathollah ; Mohandesi, Jamshid Aghazadeh ; Yazdian, Fatemeh ; Mokhtari-Dizaji, Manijhe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-e0e309d9aad449c6284e5d32b66b84b0929d8389e030e3f3c7e1d5213aed3e003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alginate-stabilized nanodroplets</topic><topic>Alginates - chemistry</topic><topic>Alginates - pharmacology</topic><topic>Animals</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell Line, Tumor</topic><topic>Doxorubicin - chemistry</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - pharmacology</topic><topic>Female</topic><topic>Glucuronic Acid - chemistry</topic><topic>Glucuronic Acid - pharmacology</topic><topic>Hexuronic Acids - chemistry</topic><topic>Hexuronic Acids - pharmacology</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nanoparticles - chemistry</topic><topic>Theranostic Nanomedicine - methods</topic><topic>Ultrasound</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baghbani, Fatemeh</creatorcontrib><creatorcontrib>Moztarzadeh, Fathollah</creatorcontrib><creatorcontrib>Mohandesi, Jamshid Aghazadeh</creatorcontrib><creatorcontrib>Yazdian, Fatemeh</creatorcontrib><creatorcontrib>Mokhtari-Dizaji, Manijhe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baghbani, Fatemeh</au><au>Moztarzadeh, Fathollah</au><au>Mohandesi, Jamshid Aghazadeh</au><au>Yazdian, Fatemeh</au><au>Mokhtari-Dizaji, Manijhe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel alginate-stabilized doxorubicin-loaded nanodroplets for ultrasounic theranosis of breast cancer</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2016-12</date><risdate>2016</risdate><volume>93</volume><issue>Pt A</issue><spage>512</spage><epage>519</epage><pages>512-519</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>[Display omitted]
Perfluorocarbon nanoemulsions are a new class of multifunctional stimuli-responsive nanocarriers which combine the properties of passive-targeted drug carriers, ultrasound imaging contrast agents, and ultrasound-responsive drug delivery systems. Doxorubicin-loaded alginate stabilized perflourohexane (PFH) nanodroplets were synthesized via nanoemulsion preparation method and their ultrasound responsivity, imaging, and therapeutic properties were studied. Doxorubicin was loaded into the nanodroplets (39.2nm) with encapsulation efficiency of 92.2%. In vitro release profile of doxorubicin from nanodroplets was an apparently biphasic release process and 12.6% of drug released from nanodroplets after 24h incubation in PBS, pH=7.4. Sonication with 28kHz therapeutic ultrasound for 10min triggered droplet-to-bubble transition in PFH nanodroplets which resulted in the release of 85.95% of doxorubicin from nanodroplets. Microbubbles formed by acoustic vaporization of the nanodroplets underwent inertial cavitation.
In the breast cancer mice models, ultrasound-mediated therapy with doxorubicin-loaded PFH nanodroplets showed excellent anti-cancer effects characterized by tumor regression. Complete tumor regression was observed for the group in which doxorubicin-loaded nanodroplets were combined with ultrasound, whereas the tumor growth inhibition of doxorubicin −loaded nanodroplets was 89.6%. These multifunctional nanodroplets, with excellent therapeutic and ultrasound properties, could be promising drug delivery systems for chemotherapeutic application.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27601134</pmid><doi>10.1016/j.ijbiomac.2016.09.008</doi><tpages>8</tpages></addata></record> |
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| subjects | Alginate-stabilized nanodroplets Alginates - chemistry Alginates - pharmacology Animals Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Doxorubicin - chemistry Doxorubicin - pharmacology Drug Carriers - chemistry Drug Carriers - pharmacology Female Glucuronic Acid - chemistry Glucuronic Acid - pharmacology Hexuronic Acids - chemistry Hexuronic Acids - pharmacology Humans Mice Mice, Inbred BALB C Nanoparticles - chemistry Theranostic Nanomedicine - methods Ultrasound Xenograft Model Antitumor Assays |
| title | Novel alginate-stabilized doxorubicin-loaded nanodroplets for ultrasounic theranosis of breast cancer |
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