Selective scavenging of intra-mitochondrial superoxide corrects diclofenac-induced mitochondrial dysfunction and gastric injury: A novel gastroprotective mechanism independent of gastric acid suppression

[Display omitted] Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat multiple inflammatory diseases and pain but severe gastric mucosal damage is the worst outcome of NSAID-therapy. Here we report that mitoTEMPO, a mitochondrially targeted superoxide (O2−) scavenger protected as...

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Veröffentlicht in:	Biochemical pharmacology 2016-12, Vol.121, p.33-51
Hauptverfasser:	Mazumder, Somnath, De, Rudranil, Sarkar, Souvik, Siddiqui, Asim Azhar, Saha, Shubhra Jyoti, Banerjee, Chinmoy, Iqbal, Mohd. Shameel, Nag, Shiladitya, Debsharma, Subhashis, Bandyopadhyay, Uday
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - adverse effects Apoptosis - drug effects Cell Line Chemotaxis, Leukocyte - drug effects Diclofenac - adverse effects Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Gastric Acid - secretion Gastric Mucosa - drug effects Gastric Mucosa - injuries Gastric Mucosa - secretion Gastritis - metabolism Gastritis - pathology Gastritis - prevention & control Gastropathy Humans Inflammation Microscopy, Fluorescence Mitochondria Mitochondria - metabolism Mitochondrial apoptosis Mitochondrial metabolism Neutrophil Infiltration - drug effects NSAID Organophosphorus Compounds - administration & dosage Organophosphorus Compounds - therapeutic use Oxidative stress Oxidative Stress - drug effects Piperidines - administration & dosage Piperidines - therapeutic use Rats, Sprague-Dawley Superoxides - antagonists & inhibitors
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