Nonviral vector plasmid DNA encoding human proenkephalin gene attenuates inflammatory and neuropathic pain-related behaviors in mice

•Peripheral or spinal delivery of pVAX1-PENK alleviates CFA-induced pain for an extended period.•Peripheral or spinal delivery of pVAX1-PENK attenuates SNI-induced nocifensive behaviors in mice.•The analgesic effect of pVAX1-PENK is blocked by naloxone hydrochloride. Inflammatory pain and neuropathi...

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Veröffentlicht in:	Neuroscience letters 2016-11, Vol.634, p.87-93
Hauptverfasser:	Hu, Chunsheng, Cai, Zhenzhen, Lu, Yuxin, Cheng, Xiaochen, Guo, Qi, Wu, Zuze, Zhang, Qinglin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Animals Behavior, Animal DNA - administration & dosage Enkephalins - genetics Enkephalins - metabolism Freund's Adjuvant Gene transfer Genetic Therapy Genetic Vectors Humans Hyperalgesia - physiopathology Hyperalgesia - therapy Inflammation - genetics Inflammation - immunology Inflammation - physiopathology Inflammation - therapy Injections, Intramuscular Injections, Spinal Neuralgia - genetics Neuralgia - physiopathology Neuralgia - therapy Pain - genetics Pain - immunology Pain - physiopathology Pain behavior Pain Management Plasmid Plasmids Proenkephalin Protein Precursors - genetics Protein Precursors - metabolism Sciatic Nerve - injuries
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