Preparation of a purified, inactivated Japanese encephalitis (JE) virus vaccine in Vero cells

An attenuated Japanese encephalitis (JE) virus SA14-14-2 (PDK) was adapted to Vero cells, a continuous cell line that has been licensed for human vaccine production, by serial passages. The resulting virus was purified by tangential flow ultrafiltration followed by sucrose density gradient ultracent...

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Veröffentlicht in:	Biotechnology letters 2001-10, Vol.23 (19), p.1565-1573
Hauptverfasser:	SUN PYO HONG, YOO, Wang-Don, PUTNAK, Robert, SRIVASTAVA, Ashok K, ECKELS, Kenneth H, CHUNG, Yong-Ju, HYUNE MO RHO, KIM, Soo-Ok
Format:	Artikel
Sprache:	eng
Schlagworte:	alum aluminum potassium sulfate Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Immunization Industrial applications and implications. Economical aspects Japanese encephalitis virus Production of active biomolecules Ultrafiltration Vaccines Vaccins Vector-borne diseases Viruses
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