Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems

Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems

Styrene-alt-maleic acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such “n...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Langmuir 2016-11, Vol.32 (45), p.11845-11853
Hauptverfasser: Hazell, Gavin, Arnold, Thomas, Barker, Robert D, Clifton, Luke A, Steinke, Nina-Juliane, Tognoloni, Cecilia, Edler, Karen J
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 11853
container_issue 45
container_start_page 11845
container_title Langmuir
container_volume 32
creator Hazell, Gavin
Arnold, Thomas
Barker, Robert D
Clifton, Luke A
Steinke, Nina-Juliane
Tognoloni, Cecilia
Edler, Karen J
description Styrene-alt-maleic acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such “nanodiscs” and lipid monolayers adsorbed at either solid–liquid or air–liquid interfaces. This behavior has important implications for the potential uses of nanodiscs.
doi_str_mv 10.1021/acs.langmuir.6b02927
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1835001673</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1835001673</sourcerecordid><originalsourceid>FETCH-LOGICAL-a394t-a33a577bba3cb8ee970348cb06b1e4112e0b8393ad3dcda01f5830cd40ae05ac3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EoqXwBwh5WRYp4ziJk2VVlYfUQqXCglXkOBNwlUexE0T_HldpWbLxLHzuHfsQcs1gwsBnd1LZSSnrj6rTZhJl4Ce-OCFDFvrghbEvTskQRMA9EUR8QC6s3QBAwoPknAx8IXgSiXhI3uffOsdaIW0KutBbndP5j_p0vUh1TdftzmCNdClL1IpOlbvvqZU0rVYl0vF6OV2sbumzrJtcW0XXO9tiZS_JWSFLi1eHOSJv9_PX2aO3eHl4mk0XnuRJ0LqTy1CILJNcZTFiIoAHscogyhgGjPkIWcwTLnOeq1wCK8KYg8oDkAihVHxExn3v1jRfHdo2rdwrsHRusOlsymIeArBIcIcGPapMY63BIt0aXUmzSxmke6mpk5oepaYHqS52c9jQZRXmf6GjRQdAD-zjm6Yztfvw_52_SfKGDA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1835001673</pqid></control><display><type>article</type><title>Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems</title><source>ACS Publications</source><creator>Hazell, Gavin ; Arnold, Thomas ; Barker, Robert D ; Clifton, Luke A ; Steinke, Nina-Juliane ; Tognoloni, Cecilia ; Edler, Karen J</creator><creatorcontrib>Hazell, Gavin ; Arnold, Thomas ; Barker, Robert D ; Clifton, Luke A ; Steinke, Nina-Juliane ; Tognoloni, Cecilia ; Edler, Karen J</creatorcontrib><description>Styrene-alt-maleic acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such “nanodiscs” and lipid monolayers adsorbed at either solid–liquid or air–liquid interfaces. This behavior has important implications for the potential uses of nanodiscs.</description><identifier>ISSN: 0743-7463</identifier><identifier>EISSN: 1520-5827</identifier><identifier>DOI: 10.1021/acs.langmuir.6b02927</identifier><identifier>PMID: 27739678</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><ispartof>Langmuir, 2016-11, Vol.32 (45), p.11845-11853</ispartof><rights>Copyright © 2016 American Chemical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a394t-a33a577bba3cb8ee970348cb06b1e4112e0b8393ad3dcda01f5830cd40ae05ac3</citedby><cites>FETCH-LOGICAL-a394t-a33a577bba3cb8ee970348cb06b1e4112e0b8393ad3dcda01f5830cd40ae05ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.langmuir.6b02927$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.langmuir.6b02927$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27739678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hazell, Gavin</creatorcontrib><creatorcontrib>Arnold, Thomas</creatorcontrib><creatorcontrib>Barker, Robert D</creatorcontrib><creatorcontrib>Clifton, Luke A</creatorcontrib><creatorcontrib>Steinke, Nina-Juliane</creatorcontrib><creatorcontrib>Tognoloni, Cecilia</creatorcontrib><creatorcontrib>Edler, Karen J</creatorcontrib><title>Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems</title><title>Langmuir</title><addtitle>Langmuir</addtitle><description>Styrene-alt-maleic acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such “nanodiscs” and lipid monolayers adsorbed at either solid–liquid or air–liquid interfaces. This behavior has important implications for the potential uses of nanodiscs.</description><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqXwBwh5WRYp4ziJk2VVlYfUQqXCglXkOBNwlUexE0T_HldpWbLxLHzuHfsQcs1gwsBnd1LZSSnrj6rTZhJl4Ce-OCFDFvrghbEvTskQRMA9EUR8QC6s3QBAwoPknAx8IXgSiXhI3uffOsdaIW0KutBbndP5j_p0vUh1TdftzmCNdClL1IpOlbvvqZU0rVYl0vF6OV2sbumzrJtcW0XXO9tiZS_JWSFLi1eHOSJv9_PX2aO3eHl4mk0XnuRJ0LqTy1CILJNcZTFiIoAHscogyhgGjPkIWcwTLnOeq1wCK8KYg8oDkAihVHxExn3v1jRfHdo2rdwrsHRusOlsymIeArBIcIcGPapMY63BIt0aXUmzSxmke6mpk5oepaYHqS52c9jQZRXmf6GjRQdAD-zjm6Yztfvw_52_SfKGDA</recordid><startdate>20161115</startdate><enddate>20161115</enddate><creator>Hazell, Gavin</creator><creator>Arnold, Thomas</creator><creator>Barker, Robert D</creator><creator>Clifton, Luke A</creator><creator>Steinke, Nina-Juliane</creator><creator>Tognoloni, Cecilia</creator><creator>Edler, Karen J</creator><general>American Chemical Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161115</creationdate><title>Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems</title><author>Hazell, Gavin ; Arnold, Thomas ; Barker, Robert D ; Clifton, Luke A ; Steinke, Nina-Juliane ; Tognoloni, Cecilia ; Edler, Karen J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a394t-a33a577bba3cb8ee970348cb06b1e4112e0b8393ad3dcda01f5830cd40ae05ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hazell, Gavin</creatorcontrib><creatorcontrib>Arnold, Thomas</creatorcontrib><creatorcontrib>Barker, Robert D</creatorcontrib><creatorcontrib>Clifton, Luke A</creatorcontrib><creatorcontrib>Steinke, Nina-Juliane</creatorcontrib><creatorcontrib>Tognoloni, Cecilia</creatorcontrib><creatorcontrib>Edler, Karen J</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hazell, Gavin</au><au>Arnold, Thomas</au><au>Barker, Robert D</au><au>Clifton, Luke A</au><au>Steinke, Nina-Juliane</au><au>Tognoloni, Cecilia</au><au>Edler, Karen J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2016-11-15</date><risdate>2016</risdate><volume>32</volume><issue>45</issue><spage>11845</spage><epage>11853</epage><pages>11845-11853</pages><issn>0743-7463</issn><eissn>1520-5827</eissn><abstract>Styrene-alt-maleic acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such “nanodiscs” and lipid monolayers adsorbed at either solid–liquid or air–liquid interfaces. This behavior has important implications for the potential uses of nanodiscs.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>27739678</pmid><doi>10.1021/acs.langmuir.6b02927</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0743-7463
ispartof Langmuir, 2016-11, Vol.32 (45), p.11845-11853
issn 0743-7463
1520-5827
language eng
recordid cdi_proquest_miscellaneous_1835001673
source ACS Publications
title Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T01%3A08%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evidence%20of%20Lipid%20Exchange%20in%20Styrene%20Maleic%20Acid%20Lipid%20Particle%20(SMALP)%20Nanodisc%20Systems&rft.jtitle=Langmuir&rft.au=Hazell,%20Gavin&rft.date=2016-11-15&rft.volume=32&rft.issue=45&rft.spage=11845&rft.epage=11853&rft.pages=11845-11853&rft.issn=0743-7463&rft.eissn=1520-5827&rft_id=info:doi/10.1021/acs.langmuir.6b02927&rft_dat=%3Cproquest_cross%3E1835001673%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1835001673&rft_id=info:pmid/27739678&rfr_iscdi=true