The CaPTHUS score as predictor of multiglandular primary hyperparathyroidism in a European population
Purpose Focused parathyroidectomy has been proven to be a safe technique for the treatment of single-gland primary hyperparathyroidism (PHPT). The CaPTHUS scoring model has been reported to be an accurate preoperative diagnostic tool for distinguishing single-gland (SGD) from multiglandular disease...
Gespeichert in:
| Veröffentlicht in: | Langenbeck's archives of surgery 2016-11, Vol.401 (7), p.937-942 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 942 |
|---|---|
| container_issue | 7 |
| container_start_page | 937 |
| container_title | Langenbeck's archives of surgery |
| container_volume | 401 |
| creator | Mogollón-González, M. Notario-Fernández, P. Dominguez-Bastante, M. Molina-Raya, A. Serradilla-Martín, M. Muñoz-Pérez, N. Arcelus-Martínez, J. I. Villar-del-Moral, J. Jiménez-Ríos, J. A. |
| description | Purpose
Focused parathyroidectomy has been proven to be a safe technique for the treatment of single-gland primary hyperparathyroidism (PHPT). The CaPTHUS scoring model has been reported to be an accurate preoperative diagnostic tool for distinguishing single-gland (SGD) from multiglandular disease (MGD), including preoperative serum calcium and PTH values plus ultrasound and Sestamibi scanning. The purpose of the present study was to validate the CaPTHUS model for the population in southern Europe, since the North American and the European populations show different clinicopathological profiles in PHPT.
Methods
This is a retrospective review of a prospectively maintained database of patients diagnosed with PHPT who underwent surgical treatment in a single referral center. Differences between SGD and MGD groups were analyzed using chi-square and Fisher’s exact tests for categorical variables and Student’s
t
test for continuous variables. Overall diagnostic accuracy of the scoring model was assessed by the area under the receiver operating characteristic (ROC) curve (AUC). A
p
|
| doi_str_mv | 10.1007/s00423-016-1426-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1835001435</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1835001435</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-d88f9304fc5bbe9de717a9c56a5415cdec94c28efd224c03b3b5af4b2d7040373</originalsourceid><addsrcrecordid>eNp9kEtPwzAQhC0E4v0DuCAfuQTWryY5ooqXhAQS5Ww59qYNSuJgJ4fy63HV0iOnXWlnRjsfIVcMbhlAfhcBJBcZsFnGJJ9lPwfklEmhMi4VO9zvUpyQsxi_AGCWl_KYnPAcCihLdUpwsUI6N--L588PGq0PSE2kQ0DX2NEH6mvaTe3YLFvTu6k1Id2azoQ1Xa0HDIMJZlytg29cEzva9NTQhyn4AU1PBz8kx9j4_oIc1aaNeLmb5-Tz8WExf85e355e5vevmRVSjpkriroUIGurqgpLhznLTWnVzCjJlHVoS2l5gbXjXFoQlaiUqWXFXQ4SRC7Oyc02dwj-e8I46q6JFtv0PPopalYIBbDBkqRsK7XBxxiw1rtimoHe0NVbujrR1Ru6-id5rnfxU9Wh2zv-cCYB3wpiOvVLDPrLT6FPlf9J_QW_kIdk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1835001435</pqid></control><display><type>article</type><title>The CaPTHUS score as predictor of multiglandular primary hyperparathyroidism in a European population</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Mogollón-González, M. ; Notario-Fernández, P. ; Dominguez-Bastante, M. ; Molina-Raya, A. ; Serradilla-Martín, M. ; Muñoz-Pérez, N. ; Arcelus-Martínez, J. I. ; Villar-del-Moral, J. ; Jiménez-Ríos, J. A.</creator><creatorcontrib>Mogollón-González, M. ; Notario-Fernández, P. ; Dominguez-Bastante, M. ; Molina-Raya, A. ; Serradilla-Martín, M. ; Muñoz-Pérez, N. ; Arcelus-Martínez, J. I. ; Villar-del-Moral, J. ; Jiménez-Ríos, J. A.</creatorcontrib><description>Purpose
Focused parathyroidectomy has been proven to be a safe technique for the treatment of single-gland primary hyperparathyroidism (PHPT). The CaPTHUS scoring model has been reported to be an accurate preoperative diagnostic tool for distinguishing single-gland (SGD) from multiglandular disease (MGD), including preoperative serum calcium and PTH values plus ultrasound and Sestamibi scanning. The purpose of the present study was to validate the CaPTHUS model for the population in southern Europe, since the North American and the European populations show different clinicopathological profiles in PHPT.
Methods
This is a retrospective review of a prospectively maintained database of patients diagnosed with PHPT who underwent surgical treatment in a single referral center. Differences between SGD and MGD groups were analyzed using chi-square and Fisher’s exact tests for categorical variables and Student’s
t
test for continuous variables. Overall diagnostic accuracy of the scoring model was assessed by the area under the receiver operating characteristic (ROC) curve (AUC). A
p
< 0.05 level was accepted as significant.
Results
From January 2001 to November 2014, 241 patients were included in the study, of whom 92.1 % had SGD and 71.8 % had a CaPTHUS score ≥3. SGD was distinguished from MGD (
p
< 0.001) using the dichotomous scoring model based on an AUC value of 0.762. Scores ≥3 had a sensitivity of 76.5 % and a positive predictive value of 96 % for SGD.
Conclusions
Despite good test performance, a CaPTHUS score ≥3 does not discard MGD definitely. Intraoperative adjuncts are still needed to further reduce the risk of missing MGD during selective parathyroidectomy.</description><identifier>ISSN: 1435-2443</identifier><identifier>EISSN: 1435-2451</identifier><identifier>DOI: 10.1007/s00423-016-1426-z</identifier><identifier>PMID: 27080995</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdominal Surgery ; Aged ; Calcium - blood ; Cardiac Surgery ; Female ; General Surgery ; Humans ; Hyperparathyroidism, Primary - blood ; Hyperparathyroidism, Primary - diagnosis ; Hyperparathyroidism, Primary - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Parathyroid Hormone - blood ; Parathyroidectomy ; Predictive Value of Tests ; Radionuclide Imaging ; Retrospective Studies ; ROC Curve ; Spain ; Thoracic Surgery ; Traumatic Surgery ; Ultrasonography ; Vascular Surgery</subject><ispartof>Langenbeck's archives of surgery, 2016-11, Vol.401 (7), p.937-942</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-d88f9304fc5bbe9de717a9c56a5415cdec94c28efd224c03b3b5af4b2d7040373</citedby><cites>FETCH-LOGICAL-c344t-d88f9304fc5bbe9de717a9c56a5415cdec94c28efd224c03b3b5af4b2d7040373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00423-016-1426-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00423-016-1426-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27080995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mogollón-González, M.</creatorcontrib><creatorcontrib>Notario-Fernández, P.</creatorcontrib><creatorcontrib>Dominguez-Bastante, M.</creatorcontrib><creatorcontrib>Molina-Raya, A.</creatorcontrib><creatorcontrib>Serradilla-Martín, M.</creatorcontrib><creatorcontrib>Muñoz-Pérez, N.</creatorcontrib><creatorcontrib>Arcelus-Martínez, J. I.</creatorcontrib><creatorcontrib>Villar-del-Moral, J.</creatorcontrib><creatorcontrib>Jiménez-Ríos, J. A.</creatorcontrib><title>The CaPTHUS score as predictor of multiglandular primary hyperparathyroidism in a European population</title><title>Langenbeck's archives of surgery</title><addtitle>Langenbecks Arch Surg</addtitle><addtitle>Langenbecks Arch Surg</addtitle><description>Purpose
Focused parathyroidectomy has been proven to be a safe technique for the treatment of single-gland primary hyperparathyroidism (PHPT). The CaPTHUS scoring model has been reported to be an accurate preoperative diagnostic tool for distinguishing single-gland (SGD) from multiglandular disease (MGD), including preoperative serum calcium and PTH values plus ultrasound and Sestamibi scanning. The purpose of the present study was to validate the CaPTHUS model for the population in southern Europe, since the North American and the European populations show different clinicopathological profiles in PHPT.
Methods
This is a retrospective review of a prospectively maintained database of patients diagnosed with PHPT who underwent surgical treatment in a single referral center. Differences between SGD and MGD groups were analyzed using chi-square and Fisher’s exact tests for categorical variables and Student’s
t
test for continuous variables. Overall diagnostic accuracy of the scoring model was assessed by the area under the receiver operating characteristic (ROC) curve (AUC). A
p
< 0.05 level was accepted as significant.
Results
From January 2001 to November 2014, 241 patients were included in the study, of whom 92.1 % had SGD and 71.8 % had a CaPTHUS score ≥3. SGD was distinguished from MGD (
p
< 0.001) using the dichotomous scoring model based on an AUC value of 0.762. Scores ≥3 had a sensitivity of 76.5 % and a positive predictive value of 96 % for SGD.
Conclusions
Despite good test performance, a CaPTHUS score ≥3 does not discard MGD definitely. Intraoperative adjuncts are still needed to further reduce the risk of missing MGD during selective parathyroidectomy.</description><subject>Abdominal Surgery</subject><subject>Aged</subject><subject>Calcium - blood</subject><subject>Cardiac Surgery</subject><subject>Female</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Hyperparathyroidism, Primary - blood</subject><subject>Hyperparathyroidism, Primary - diagnosis</subject><subject>Hyperparathyroidism, Primary - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Parathyroid Hormone - blood</subject><subject>Parathyroidectomy</subject><subject>Predictive Value of Tests</subject><subject>Radionuclide Imaging</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Spain</subject><subject>Thoracic Surgery</subject><subject>Traumatic Surgery</subject><subject>Ultrasonography</subject><subject>Vascular Surgery</subject><issn>1435-2443</issn><issn>1435-2451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0E4v0DuCAfuQTWryY5ooqXhAQS5Ww59qYNSuJgJ4fy63HV0iOnXWlnRjsfIVcMbhlAfhcBJBcZsFnGJJ9lPwfklEmhMi4VO9zvUpyQsxi_AGCWl_KYnPAcCihLdUpwsUI6N--L588PGq0PSE2kQ0DX2NEH6mvaTe3YLFvTu6k1Id2azoQ1Xa0HDIMJZlytg29cEzva9NTQhyn4AU1PBz8kx9j4_oIc1aaNeLmb5-Tz8WExf85e355e5vevmRVSjpkriroUIGurqgpLhznLTWnVzCjJlHVoS2l5gbXjXFoQlaiUqWXFXQ4SRC7Oyc02dwj-e8I46q6JFtv0PPopalYIBbDBkqRsK7XBxxiw1rtimoHe0NVbujrR1Ru6-id5rnfxU9Wh2zv-cCYB3wpiOvVLDPrLT6FPlf9J_QW_kIdk</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Mogollón-González, M.</creator><creator>Notario-Fernández, P.</creator><creator>Dominguez-Bastante, M.</creator><creator>Molina-Raya, A.</creator><creator>Serradilla-Martín, M.</creator><creator>Muñoz-Pérez, N.</creator><creator>Arcelus-Martínez, J. I.</creator><creator>Villar-del-Moral, J.</creator><creator>Jiménez-Ríos, J. A.</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>The CaPTHUS score as predictor of multiglandular primary hyperparathyroidism in a European population</title><author>Mogollón-González, M. ; Notario-Fernández, P. ; Dominguez-Bastante, M. ; Molina-Raya, A. ; Serradilla-Martín, M. ; Muñoz-Pérez, N. ; Arcelus-Martínez, J. I. ; Villar-del-Moral, J. ; Jiménez-Ríos, J. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-d88f9304fc5bbe9de717a9c56a5415cdec94c28efd224c03b3b5af4b2d7040373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abdominal Surgery</topic><topic>Aged</topic><topic>Calcium - blood</topic><topic>Cardiac Surgery</topic><topic>Female</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Hyperparathyroidism, Primary - blood</topic><topic>Hyperparathyroidism, Primary - diagnosis</topic><topic>Hyperparathyroidism, Primary - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Parathyroid Hormone - blood</topic><topic>Parathyroidectomy</topic><topic>Predictive Value of Tests</topic><topic>Radionuclide Imaging</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Spain</topic><topic>Thoracic Surgery</topic><topic>Traumatic Surgery</topic><topic>Ultrasonography</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mogollón-González, M.</creatorcontrib><creatorcontrib>Notario-Fernández, P.</creatorcontrib><creatorcontrib>Dominguez-Bastante, M.</creatorcontrib><creatorcontrib>Molina-Raya, A.</creatorcontrib><creatorcontrib>Serradilla-Martín, M.</creatorcontrib><creatorcontrib>Muñoz-Pérez, N.</creatorcontrib><creatorcontrib>Arcelus-Martínez, J. I.</creatorcontrib><creatorcontrib>Villar-del-Moral, J.</creatorcontrib><creatorcontrib>Jiménez-Ríos, J. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langenbeck's archives of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mogollón-González, M.</au><au>Notario-Fernández, P.</au><au>Dominguez-Bastante, M.</au><au>Molina-Raya, A.</au><au>Serradilla-Martín, M.</au><au>Muñoz-Pérez, N.</au><au>Arcelus-Martínez, J. I.</au><au>Villar-del-Moral, J.</au><au>Jiménez-Ríos, J. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The CaPTHUS score as predictor of multiglandular primary hyperparathyroidism in a European population</atitle><jtitle>Langenbeck's archives of surgery</jtitle><stitle>Langenbecks Arch Surg</stitle><addtitle>Langenbecks Arch Surg</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>401</volume><issue>7</issue><spage>937</spage><epage>942</epage><pages>937-942</pages><issn>1435-2443</issn><eissn>1435-2451</eissn><abstract>Purpose
Focused parathyroidectomy has been proven to be a safe technique for the treatment of single-gland primary hyperparathyroidism (PHPT). The CaPTHUS scoring model has been reported to be an accurate preoperative diagnostic tool for distinguishing single-gland (SGD) from multiglandular disease (MGD), including preoperative serum calcium and PTH values plus ultrasound and Sestamibi scanning. The purpose of the present study was to validate the CaPTHUS model for the population in southern Europe, since the North American and the European populations show different clinicopathological profiles in PHPT.
Methods
This is a retrospective review of a prospectively maintained database of patients diagnosed with PHPT who underwent surgical treatment in a single referral center. Differences between SGD and MGD groups were analyzed using chi-square and Fisher’s exact tests for categorical variables and Student’s
t
test for continuous variables. Overall diagnostic accuracy of the scoring model was assessed by the area under the receiver operating characteristic (ROC) curve (AUC). A
p
< 0.05 level was accepted as significant.
Results
From January 2001 to November 2014, 241 patients were included in the study, of whom 92.1 % had SGD and 71.8 % had a CaPTHUS score ≥3. SGD was distinguished from MGD (
p
< 0.001) using the dichotomous scoring model based on an AUC value of 0.762. Scores ≥3 had a sensitivity of 76.5 % and a positive predictive value of 96 % for SGD.
Conclusions
Despite good test performance, a CaPTHUS score ≥3 does not discard MGD definitely. Intraoperative adjuncts are still needed to further reduce the risk of missing MGD during selective parathyroidectomy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27080995</pmid><doi>10.1007/s00423-016-1426-z</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1435-2443 |
| ispartof | Langenbeck's archives of surgery, 2016-11, Vol.401 (7), p.937-942 |
| issn | 1435-2443 1435-2451 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1835001435 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Abdominal Surgery Aged Calcium - blood Cardiac Surgery Female General Surgery Humans Hyperparathyroidism, Primary - blood Hyperparathyroidism, Primary - diagnosis Hyperparathyroidism, Primary - surgery Male Medicine Medicine & Public Health Middle Aged Original Article Parathyroid Hormone - blood Parathyroidectomy Predictive Value of Tests Radionuclide Imaging Retrospective Studies ROC Curve Spain Thoracic Surgery Traumatic Surgery Ultrasonography Vascular Surgery |
| title | The CaPTHUS score as predictor of multiglandular primary hyperparathyroidism in a European population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T20%3A59%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20CaPTHUS%20score%20as%20predictor%20of%20multiglandular%20primary%20hyperparathyroidism%20in%20a%20European%20population&rft.jtitle=Langenbeck's%20archives%20of%20surgery&rft.au=Mogoll%C3%B3n-Gonz%C3%A1lez,%20M.&rft.date=2016-11-01&rft.volume=401&rft.issue=7&rft.spage=937&rft.epage=942&rft.pages=937-942&rft.issn=1435-2443&rft.eissn=1435-2451&rft_id=info:doi/10.1007/s00423-016-1426-z&rft_dat=%3Cproquest_cross%3E1835001435%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1835001435&rft_id=info:pmid/27080995&rfr_iscdi=true |