Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial

Summary Background Delirium is a postoperative complication that occurs frequently in patients older than 65 years, and presages adverse outcomes. We investigated whether prophylactic low-dose dexmedetomidine, a highly selective α2 adrenoceptor agonist, could safely decrease the incidence of deliriu...

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Veröffentlicht in:	The Lancet (British edition) 2016-10, Vol.388 (10054), p.1893-1902
Hauptverfasser:	Su, Xian, MD, Meng, Zhao-Ting, MD, Wu, Xin-Hai, MD, Cui, Fan, MD, Li, Hong-Liang, MD, Wang, Dong-Xin, Prof, Zhu, Xi, Prof, Zhu, Sai-Nan, MS, Maze, Mervyn, Prof, Ma, Daqing, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Agonists - administration & dosage Adrenergic alpha-2 Receptor Agonists - therapeutic use Aged Analgesics, Non-Narcotic - therapeutic use Anesthesia China - epidemiology Clinical trials Confusion - diagnosis Confusion - etiology Confusion - prevention & control Critical Care - methods Delirium Delirium - diagnosis Delirium - epidemiology Delirium - etiology Delirium - prevention & control Dexmedetomidine - administration & dosage Dexmedetomidine - therapeutic use Double-Blind Method Drug Administration Schedule Drug dosages Evidence-Based Medicine Female Hospitals Humans Hypertension Incidence Infusions, Intravenous Intensive Care Units - statistics & numerical data Internal Medicine Male Mental disorders Middle Aged Older people Patients Postoperative period Preventive medicine Primary Prevention - methods Respiration, Artificial - adverse effects Surgery Surgical Procedures, Operative - adverse effects Time Factors Treatment Outcome
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