Docosahexaenoic Acid Reduces Cerebral Damage and Ameliorates Long-Term Cognitive Impairments Caused by Neonatal Hypoxia–Ischemia in Rats

As the interest in the neuroprotective possibilities of docosahexaenoic acid (DHA) for brain injury has grown in the recent years, we aimed to investigate the long-term effects of this fatty acid in an experimental model of perinatal hypoxia–ischemia in rats. To this end, motor activity, aspects of...

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Veröffentlicht in:	Molecular neurobiology 2017-11, Vol.54 (9), p.7137-7155
Hauptverfasser:	Arteaga, Olatz, Revuelta, M., Urigüen, L., Martínez-Millán, L., Hilario, E., Álvarez, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Animals, Newborn Anxiety Axons - drug effects Axons - pathology Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Brain Brain - drug effects Brain - pathology Brain - physiopathology Brain injury Cell Biology Cognitive ability Cognitive Dysfunction - drug therapy Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology DNA damage Docosahexaenoic acid Docosahexaenoic Acids - pharmacology Docosahexaenoic Acids - therapeutic use Glial Fibrillary Acidic Protein - metabolism Gliosis - pathology Hippocampus - pathology Hypoxia Hypoxia-Ischemia, Brain - complications Hypoxia-Ischemia, Brain - drug therapy Hypoxia-Ischemia, Brain - physiopathology Ischemia Locomotor activity Long-term effects Membrane potential Membrane Potential, Mitochondrial - drug effects Mental disorders Microglia - drug effects Microglia - metabolism Microglia - pathology Mitochondria Mitochondria - drug effects Mitochondria - metabolism Motor activity Motor Activity - drug effects Motor skill learning Myelin Myelin Basic Protein - metabolism Neonates Neurobiology Neurology Neuroprotection Neurosciences Rats Rats, Sprague-Dawley Rodents Short term memory Spatial Memory - drug effects Traumatic brain injury
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