DNA Repair by DNA: The UV1C DNAzyme Catalyzes Photoreactivation of Cyclobutane Thymine Dimers in DNA More Effectively than Their de Novo Formation

UV1C, a 42-nt DNA oligonucleotide, is a deoxyribozyme (DNAzyme) that optimally uses 305 nm wavelength light to catalyze photoreactivation of a cyclobutane thymine dimer placed within a gapped, unnatural DNA substrate, TDP. Herein we show that UV1C is also capable of photoreactivating thymine dimers...

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Veröffentlicht in:	Biochemistry (Easton) 2016-11, Vol.55 (43), p.6010-6018
Hauptverfasser:	Barlev, Adam, Sekhon, Gurpreet S, Bennet, Andrew J, Sen, Dipankar
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - metabolism DNA Repair DNA, Catalytic - metabolism Photochemistry Pyrimidine Dimers - metabolism
Online-Zugang:	Volltext
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