Expression of Functional Chemokine Receptors CXCR3 and CXCR4 on Human Melanoma Cells

Chemokines are secreted into the tumor microenvironment by tumor-infiltrating inflammatory cells as well as by tumor cells. Chemokine receptors mediate agonist-dependent cell responses, including migration and activation of several signaling pathways. In the present study we show that several human...

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Veröffentlicht in:	The Journal of biological chemistry 2001-11, Vol.276 (48), p.45098-45105
Hauptverfasser:	Robledo, M M, Bartolome, R A, Longo, N, Rodríguez-Frade, J M, Mellado, M, Longo, I, van Muijen, G N, Sánchez-Mateos, P, Teixidó, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Blotting, Western Cell Adhesion Cell Division Cell Movement Cell Survival Chemotaxis CXCR3 protein CXCR4 protein Dose-Response Relationship, Drug fibronectin Fibronectins - metabolism Flow Cytometry GTP Phosphohydrolases - metabolism Humans Immunohistochemistry Ligands Melanoma - metabolism Microscopy, Fluorescence Neoplasm Invasiveness Neoplasm Metastasis Protein Binding rac1 GTP-Binding Protein - metabolism Receptors, Chemokine - biosynthesis Receptors, CXCR3 Receptors, CXCR4 - biosynthesis rhoA GTP-Binding Protein - metabolism Signal Transduction Time Factors Tumor Cells, Cultured VLA-4 antigen
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