PHOSPHATIDYLINOSITOL 3-KINASE REGULATES PROLIFERATION OF RAW 264.7 MACROPHAGES

Phosphatidylinositol 3-kinase (PI3-kinase) is an enzyme that acts as a direct biochemical link between a novel phosphatidylinositol pathway and a number of proteins containing intrinsic or associated kinase activities. Here we demonstrate that wortmannin, PI3-kinase inhibitor, decreases the prolifer...

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Veröffentlicht in:	Immunopharmacology and immunotoxicology 2001-01, Vol.23 (3), p.355-365
Hauptverfasser:	Kim, Hyung-Min, Yim, Hee-Gyun, Yoon, Hyang-Suk, Park, Seung-Taeck, Jeung, Jae-Yeal, Lee, Ki-Nam, Baek, Seung-Hwa, Song, Yung-Sun, Oh, Gyung-Jae, Kim, Nam-Song, An, Nyeon-Hyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Biological and medical sciences c-fos c-jun Cell Cycle - drug effects Cell cycle, cell proliferation Cell Division - drug effects Cell Division - physiology Cell Line Cell physiology Chromones - pharmacology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Genes, fos - drug effects Genes, jun - drug effects Macrophages - cytology Macrophages - drug effects Macrophages - enzymology Mice Molecular and cellular biology Morpholines - pharmacology phorbol 12-myristate 13-acetate Phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology Protein kinase C RAW 264.7 macrophages RNA, Messenger - genetics RNA, Messenger - metabolism Tetradecanoylphorbol Acetate - pharmacology wortmannin
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